1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	C	C	S	T	A	A	K	S	A	V	I	V	C	C	A	A	I	A	T	T	A	C	S	F	Q	A	T	S	T	Q	P	S	T	A	P	P	T	S	R	V	D	S	L	I	V	S	I	E	D	V	R	R	I	A	N	Y	E	E	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																?	?				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	H	F	Q	T	D	L	R	E	P	P	E	A	D	T	N	V	P	G	P	C	R	V	V	G	S	S	D	R	T	F	G	T	D	W	S	E	F	R	S	A	G	Y	H	G	V	T	D	D	L	R	P	G	G	P	V	M	V	E
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?		?	?	?																		?												?		?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	V	S	Q	A	I	A	L	Y	P	D	P	S	T	A	R	G	V	F	H	R	L	E	S	S	L	A	E	C	A	G	L	H	D	P	Y	F	D	F	I	L	D	R	P	D	A	S	T	V	R	I	G	A	A	G	W	S	H	V	Y
Secondary structure
SS confidence
Disorder																																													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.
Sequence		R	L	K	S	S	V	F	I	S	V	G	V	L	G	I	E	P	A	E	P	I	A	N	V	I	L	Q	T	I	S	D	R	I	Q
Secondary structure
SS confidence
Disorder																																		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 50%) Beta strand ( 9%)

Rank Aligned region

PDB 4esq chain A Region: 35 - 213 Aligned: 171 Modelled: 179 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:serine/threonine protein kinase; PDBTitle: crystal structure of the extracellular domain of pknh from2 mycobacterium tuberculosis Phyre2 PDB 3lo3 chain E Region: 125 - 141 Aligned: 17 Modelled: 17 Confidence: 37.2% Identity: 24% PDB header:structure genomics, unknown function Chain: E: PDB Molecule:uncharacterized conserved protein; PDBTitle: the crystal structure of a conserved functionally unknown protein from2 colwellia psychrerythraea 34h. Phyre2 PDB 2fiu chain A domain 1 Region: 125 - 141 Aligned: 17 Modelled: 17 Confidence: 35.6% Identity: 12% Fold: Ferredoxin-like Superfamily: Dimeric alpha+beta barrel Family: Atu0297-like Phyre2 PDB 3dca chain C Region: 115 - 141 Aligned: 27 Modelled: 23 Confidence: 20.8% Identity: 22% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:rpa0582; PDBTitle: crystal structure of the rpa0582- protein of unknown2 function from rhodopseudomonas palustris- a structural3 genomics target Phyre2 PDB 1kr4 chain A Region: 119 - 151 Aligned: 33 Modelled: 32 Confidence: 17.1% Identity: 18% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Divalent ion tolerance proteins CutA (CutA1) Phyre2 PDB 2b3g chain B Region: 35 - 53 Aligned: 19 Modelled: 19 Confidence: 14.4% Identity: 26% PDB header:replication Chain: B: PDB Molecule:cellular tumor antigen p53; PDBTitle: p53n (fragment 33-60) bound to rpa70n Phyre2 PDB 1vhf chain A Region: 121 - 151 Aligned: 31 Modelled: 31 Confidence: 11.5% Identity: 19% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Divalent ion tolerance proteins CutA (CutA1) Phyre2 PDB 4iyq chain B Region: 120 - 151 Aligned: 32 Modelled: 32 Confidence: 10.0% Identity: 25% PDB header:protein binding Chain: B: PDB Molecule:divalent ion tolerance protein cuta1; PDBTitle: crystal structure of divalent ion tolerance protein cuta1 from2 ehrlichia chaffeensis Phyre2 PDB 2zfh chain A domain 1 Region: 125 - 151 Aligned: 27 Modelled: 27 Confidence: 9.7% Identity: 26% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Divalent ion tolerance proteins CutA (CutA1) Phyre2 PDB 1xk8 chain A Region: 125 - 151 Aligned: 27 Modelled: 27 Confidence: 9.7% Identity: 26% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:divalent cation tolerant protein cuta; PDBTitle: divalent cation tolerant protein cuta from homo sapiens o60888 Phyre2 PDB 3i08 chain D Region: 129 - 145 Aligned: 17 Modelled: 17 Confidence: 9.6% Identity: 12% PDB header:signaling protein Chain: D: PDB Molecule:neurogenic locus notch homolog protein 1; PDBTitle: crystal structure of the s1-cleaved notch1 negative2 regulatory region (nrr) Phyre2 PDB 1lmm chain A Region: 145 - 153 Aligned: 9 Modelled: 9 Confidence: 9.5% Identity: 22% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: omega toxin-like Family: Spider toxins Phyre2 PDB 1uku chain A Region: 122 - 151 Aligned: 30 Modelled: 30 Confidence: 9.3% Identity: 27% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Divalent ion tolerance proteins CutA (CutA1) Phyre2 PDB 6osw chain A Region: 126 - 157 Aligned: 32 Modelled: 32 Confidence: 9.0% Identity: 16% PDB header:cell cycle Chain: A: PDB Molecule:forkhead box m1; PDBTitle: an order-to-disorder structural switch activates the foxm12 transcription factor Phyre2 PDB 6gdx chain A Region: 121 - 151 Aligned: 31 Modelled: 31 Confidence: 8.5% Identity: 16% PDB header:metal binding protein Chain: A: PDB Molecule:periplasmic divalent cation tolerance protein; PDBTitle: structure of cuta from synechococcus elongatus pcc7942 complexed with2 3 molecules of bis-tris Phyre2 PDB 1j1t chain A Region: 170 - 185 Aligned: 16 Modelled: 16 Confidence: 8.3% Identity: 38% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Alginate lyase Phyre2 PDB 1osc chain E Region: 114 - 151 Aligned: 38 Modelled: 38 Confidence: 8.1% Identity: 26% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Divalent ion tolerance proteins CutA (CutA1) Phyre2 PDB 4e98 chain C Region: 121 - 151 Aligned: 31 Modelled: 31 Confidence: 7.7% Identity: 16% PDB header:signaling protein Chain: C: PDB Molecule:cuta1 divalent ion tolerance protein; PDBTitle: crystal structure of possible cuta1 divalent ion tolerance protein2 from cryptosporidium parvum iowa ii Phyre2 PDB 2mzd chain B Region: 37 - 53 Aligned: 17 Modelled: 17 Confidence: 7.6% Identity: 29% PDB header:protein binding Chain: B: PDB Molecule:cellular tumor antigen p53; PDBTitle: characterization of the p300 taz2-p53 tad2 complex and comparison with2 the p300 taz2-p53 tad1 complex Phyre2 PDB 2ly4 chain B Region: 35 - 51 Aligned: 17 Modelled: 17 Confidence: 6.8% Identity: 29% PDB header:nuclear protein/antitumour protein Chain: B: PDB Molecule:cellular tumor antigen p53; PDBTitle: hmgb1-facilitated p53 dna binding occurs via hmg-box/p532 transactivation domain interaction and is regulated by the acidic3 tail Phyre2 1 c4esqA_ 2 c3lo3E_ 3 d2fiua1 4 c3dcaC_ 5 d1kr4a_ 6 c2b3gB_ 7 d1vhfa_ 8 c4iyqB_ 9 d2zfha1 10 c1xk8A_ 11 c3i08D_ 12 d1lmma_ 13 d1ukua_ 14 c6oswA_ 15 c6gdxA_ 16 d1j1ta_ 17 d1osce_ 18 c4e98C_ 19 c2mzdB_ 20 c2ly4B_ 21 22 23 24 25 26 27 28