1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	E	L	A	T	S	G	N	A	F	D	K	R	R	F	S	R	R	G	F	L	G	A	G	I	A	S	G	F	A	L	A	A	C	A	S	K	P	T	A	S	G	A	A	G	M	T	A	A	I	D	A	A	E	A	A	R	P	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?																						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	G	R	T	V	T	A	T	L	T	P	Q	P	A	R	I	D	L	G	G	P	I	V	S	T	L	T	Y	G	N	T	I	P	G	P	L	I	R	A	T	V	G	D	E	I	V	V	S	V	T	N	R	L	G	D	P	T	S	V	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	H	G	I	A	L	R	N	D	M	D	G	T	E	P	A	T	A	N	I	G	P	G	G	D	F	T	Y	R	F	S	V	P	D	P	G	T	Y	W	A	H	P	H	V	G	L	Q	G	D	H	G	L	Y	L	P	V	V	V	D	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	T	E	P	G	H	Y	D	A	E	W	I	I	I	L	D	D	W	T	D	G	I	G	K	S	P	Q	Q	L	Y	G	E	L	T	D	P	N	K	P	T	M	Q	N	T	T	G	M	P	E	G	E	G	V	D	S	N	L	L	G	G
Secondary structure
SS confidence
Disorder																											?						?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	G	G	D	I	A	Y	P	Y	Y	L	I	N	G	R	I	P	V	A	A	T	S	F	K	A	K	P	G	Q	R	I	R	I	R	I	I	N	S	A	A	D	T	A	F	R	I	A	L	A	G	H	S	M	T	V	T	H	T	D	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	P	V	I	P	T	E	V	D	A	L	L	I	G	M	A	E	R	Y	D	V	M	V	T	A	A	G	G	V	F	P	L	V	A	L	A	E	G	K	N	A	L	A	R	A	L	L	S	T	G	A	G	S	P	P	D	P	Q	F	R
Secondary structure
SS confidence
Disorder									?																															?												?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	D	E	L	N	W	R	V	G	T	V	E	M	F	T	A	A	T	T	A	N	L	G	R	P	E	P	T	H	D	L	P	V	T	L	G	G	T	M	A	K	Y	D	W	T	I	N	G	E	P	Y	S	T	T	N	P	L	H	V	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?									?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	G	Q	R	P	T	L	M	F	D	N	T	T	M	M	Y	H	P	I	H	L	H	G	H	T	F	Q	M	I	K	A	D	G	S	P	G	A	R	K	D	T	V	I	V	L	P	K	Q	K	M	R	A	V	L	V	A	D	N	P	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.
Sequence		V	W	V	M	H	C	H	N	N	Y	H	Q	V	A	G	M	A	T	R	L	D	Y	I	L
Secondary structure
SS confidence
Disorder																									?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 7%) Beta strand ( 40%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 3sqr chain A Region: 34 - 502 Aligned: 453 Modelled: 469 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:laccase; PDBTitle: crystal structure of laccase from botrytis aclada at 1.67 a resolution Phyre2 PDB 1zpu chain E Region: 63 - 500 Aligned: 411 Modelled: 414 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: E: PDB Molecule:iron transport multicopper oxidase fet3; PDBTitle: crystal structure of fet3p, a multicopper oxidase that functions in2 iron import Phyre2 PDB 5lwx chain A Region: 37 - 500 Aligned: 445 Modelled: 445 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:multicopper oxidase; PDBTitle: crystal structure of the h253d mutant of mcog from aspergillus niger Phyre2 PDB 3pps chain D Region: 55 - 500 Aligned: 417 Modelled: 417 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: D: PDB Molecule:laccase; PDBTitle: crystal structure of an ascomycete fungal laccase from thielavia2 arenaria Phyre2 PDB 2q9o chain A Region: 58 - 500 Aligned: 414 Modelled: 414 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:laccase-1; PDBTitle: near-atomic resolution structure of a melanocarpus albomyces laccase Phyre2 PDB 3zx1 chain A Region: 30 - 503 Aligned: 438 Modelled: 447 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:oxidoreductase, putative; PDBTitle: multicopper oxidase from campylobacter jejuni: a metallo-oxidase Phyre2 PDB 1asq chain B Region: 63 - 502 Aligned: 437 Modelled: 440 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: B: PDB Molecule:ascorbate oxidase; PDBTitle: x-ray structures and mechanistic implications of three functional2 derivatives of ascorbate oxidase from zucchini: reduced-, peroxide-,3 and azide-forms Phyre2 PDB 1gyc chain A Region: 66 - 502 Aligned: 409 Modelled: 412 Confidence: 100.0% Identity: 26% PDB header:oxidoreductase Chain: A: PDB Molecule:laccase 2; PDBTitle: crystal structure determination at room temperature of a laccase from2 trametes versicolor in its oxidised form containing a full complement3 of copper ions Phyre2 PDB 2xu9 chain A Region: 49 - 502 Aligned: 417 Modelled: 426 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: A: PDB Molecule:laccase; PDBTitle: crystal structure of laccase from thermus thermophilus hb27 Phyre2 PDB 2xll chain C Region: 38 - 503 Aligned: 426 Modelled: 437 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: C: PDB Molecule:bilirubin oxidase; PDBTitle: the crystal structure of bilirubin oxidase from myrothecium2 verrucaria Phyre2 PDB 5dao chain A Region: 67 - 502 Aligned: 402 Modelled: 402 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:laccase; PDBTitle: laccase from antrodiella faginea Phyre2 PDB 3t6v chain A Region: 66 - 502 Aligned: 404 Modelled: 404 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:laccase; PDBTitle: crystal structure of laccase from steccherinum ochraceum Phyre2 PDB 1v10 chain A Region: 63 - 502 Aligned: 408 Modelled: 413 Confidence: 100.0% Identity: 28% PDB header:oxidase Chain: A: PDB Molecule:laccase; PDBTitle: structure of rigidoporus lignosus laccase from hemihedrally2 twinned crystals Phyre2 PDB 3abg chain A Region: 38 - 504 Aligned: 430 Modelled: 438 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:bilirubin oxidase; PDBTitle: x-ray crystal analysis of bilirubin oxidase from myrothecium2 verrucaria at 2.3 angstrom resolution using a twin crystal Phyre2 PDB 1of0 chain A Region: 44 - 503 Aligned: 439 Modelled: 440 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:spore coat protein a; PDBTitle: crystal structure of bacillus subtilis cota after 1h soaking with abts Phyre2 PDB 2fqe chain A Region: 51 - 502 Aligned: 414 Modelled: 426 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:blue copper oxidase cueo; PDBTitle: crystal structures of e. coli laccase cueo under different copper2 binding situations Phyre2 PDB 1a65 chain A Region: 66 - 502 Aligned: 407 Modelled: 411 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:laccase; PDBTitle: type-2 cu-depleted laccase from coprinus cinereus Phyre2 PDB 2yxw chain B Region: 51 - 502 Aligned: 412 Modelled: 426 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: B: PDB Molecule:blue copper oxidase cueo; PDBTitle: the deletion mutant of multicopper oxidase cueo Phyre2 PDB 6evg chain A Region: 50 - 503 Aligned: 417 Modelled: 423 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:multi-copper oxidase cueo; PDBTitle: structural and functional characterisation of a bacterial laccase-like2 multi-copper oxidase cueo from lignin-degrading bacterium3 ochrobactrum sp. with oxidase activity towards lignin model compounds4 and lignosulfonate Phyre2 PDB 2g23 chain G Region: 40 - 503 Aligned: 446 Modelled: 453 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: G: PDB Molecule:phenoxazinone synthase; PDBTitle: the crystal structure of hexameric phenoxazinone synthase Phyre2 1 c3sqrA_ 2 c1zpuE_ 3 c5lwxA_ 4 c3ppsD_ 5 c2q9oA_ 6 c3zx1A_ 7 c1asqB_ 8 c1gycA_ 9 c2xu9A_ 10 c2xllC_ 11 c5daoA_ 12 c3t6vA_ 13 c1v10A_ 14 c3abgA_ 15 c1of0A_ 16 c2fqeA_ 17 c1a65A_ 18 c2yxwB_ 19 c6evgA_ 20 c2g23G_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226