1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	W	M	R	S	A	I	V	A	V	A	L	G	V	T	V	A	A	V	A	A	A	C	W	L	P	Q	L	H	R	H	V	A	H	P	N	H	P	L	T	T	S	V	G	S	E	F	V	I	N	T	D	H	G	H	L	V	D	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?																									?	?	?	?	?								?	?	?	?	?								?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	M	P	P	C	P	E	R	L	A	T	A	V	L	P	R	S	A	T	P	V	L	L	P	D	V	V	A	A	A	P	G	M	T	A	A	L	T	D	P	V	A	P	A	A	R	G	P	P	A	A	Q	G	S	V	R	T	G	Q	D
Secondary structure
SS confidence
Disorder		?												?	?		?	?	?	?																		?	?		?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130
Sequence		L	L	T	R	F	C	L	A	R	R
Secondary structure
SS confidence
Disorder								?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 32%) Alpha helix ( 62%) Beta strand ( 2%) TM helix ( 23%) (View membrane topology prediction)

Rank Aligned region

PDB 1rpi chain A Region: 118 - 126 Aligned: 9 Modelled: 9 Confidence: 14.8% Identity: 33% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1kzk chain A Region: 118 - 126 Aligned: 9 Modelled: 9 Confidence: 13.6% Identity: 44% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1nh0 chain A Region: 118 - 127 Aligned: 10 Modelled: 10 Confidence: 11.7% Identity: 40% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 2mic chain A Region: 58 - 74 Aligned: 17 Modelled: 17 Confidence: 11.1% Identity: 35% PDB header:membrane protein Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 16; PDBTitle: nmr structure of p75 transmembrane domain in dpc micelles Phyre2 PDB 2mic chain B Region: 58 - 74 Aligned: 17 Modelled: 17 Confidence: 11.0% Identity: 35% PDB header:membrane protein Chain: B: PDB Molecule:tumor necrosis factor receptor superfamily member 16; PDBTitle: nmr structure of p75 transmembrane domain in dpc micelles Phyre2 PDB 2nmz chain A domain 1 Region: 118 - 126 Aligned: 9 Modelled: 9 Confidence: 9.8% Identity: 44% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1az5 chain A Region: 118 - 127 Aligned: 10 Modelled: 10 Confidence: 9.2% Identity: 40% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1siv chain A Region: 118 - 125 Aligned: 8 Modelled: 8 Confidence: 8.6% Identity: 50% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1nso chain A Region: 118 - 125 Aligned: 8 Modelled: 8 Confidence: 8.0% Identity: 50% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1c6y chain A Region: 118 - 127 Aligned: 10 Modelled: 10 Confidence: 8.0% Identity: 40% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1bdq chain A Region: 118 - 127 Aligned: 10 Modelled: 10 Confidence: 7.2% Identity: 40% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1sgu chain A Region: 118 - 125 Aligned: 8 Modelled: 8 Confidence: 6.4% Identity: 38% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 4fiv chain A Region: 118 - 125 Aligned: 8 Modelled: 8 Confidence: 6.4% Identity: 38% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1bai chain A Region: 118 - 127 Aligned: 10 Modelled: 10 Confidence: 5.6% Identity: 40% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 PDB 1v5n chain A Region: 26 - 48 Aligned: 23 Modelled: 23 Confidence: 5.5% Identity: 26% Fold: Cysteine-rich domain Superfamily: Cysteine-rich domain Family: C1-like domain Phyre2 PDB 3ecg chain A domain 1 Region: 118 - 125 Aligned: 8 Modelled: 8 Confidence: 5.4% Identity: 38% Fold: Acid proteases Superfamily: Acid proteases Family: Retroviral protease (retropepsin) Phyre2 1 d1rpia_ 2 d1kzka_ 3 d1nh0a_ 4 c2micA_ 5 c2micB_ 6 d2nmza1 7 d1az5a_ 8 d1siva_ 9 d1nsoa_ 10 d1c6ya_ 11 d1bdqa_ 12 d1sgua_ 13 d4fiva_ 14 d1baia_ 15 d1v5na_ 16 d3ecga1