1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	I	K	E	S	R	D	I	V	I	E	A	S	P	E	E	I	L	D	V	I	A	D	F	E	A	M	T	E	W	S	P	A	H	Q	S	V	E	I	L	E	T	G	D	D	G	R	P	S	K	V	K	M	K	V	K	T	A	G
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	T	D	E	Q	V	V	A	Y	S	W	T	D	R	S	V	R	W	T	L	V	S	S	T	Q	Q	R	S	Q	D	G	K	Y	E	L	T	P	K	G	D	N	T	L	V	Q	F	E	I	T	V	D	P	Q	V	P	L	P	G	F	V
Secondary structure
SS confidence
Disorder		?	?																			?	?	?	?	?	?	?	?	?																							?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.
Sequence		L	K	R	A	I	K	G	T	I	D	T	A	T	E	A	L	R	S	Q	V	L	K	V	K	K	G	Q
Secondary structure
SS confidence
Disorder																								?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 28%) Beta strand ( 43%)

Rank Aligned region

PDB 2kf2 chain A Region: 1 - 147 Aligned: 147 Modelled: 147 Confidence: 99.9% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative polyketide cyclase; PDBTitle: solution nmr structure of of streptomyces coelicolor2 polyketide cyclase sco5315. northeast structural genomics3 consortium target rr365 Phyre2 PDB 2rer chain A domain 1 Region: 1 - 145 Aligned: 145 Modelled: 145 Confidence: 99.9% Identity: 19% Fold: TBP-like Superfamily: Bet v1-like Family: oligoketide cyclase/dehydrase-like Phyre2 PDB 5z8o chain A Region: 5 - 143 Aligned: 139 Modelled: 139 Confidence: 99.9% Identity: 27% PDB header:unknown function Chain: A: PDB Molecule:cyclase/dehydrase; PDBTitle: structural of start superfamily protein msmeg_0129 from mycobacterium2 smegmatis Phyre2 PDB 2d4r chain A domain 1 Region: 4 - 142 Aligned: 138 Modelled: 139 Confidence: 99.9% Identity: 15% Fold: TBP-like Superfamily: Bet v1-like Family: oligoketide cyclase/dehydrase-like Phyre2 PDB 3tfz chain B Region: 1 - 146 Aligned: 145 Modelled: 146 Confidence: 99.9% Identity: 14% PDB header:biosynthetic protein Chain: B: PDB Molecule:cyclase; PDBTitle: crystal structure of zhui aromatase/cyclase from streptomcyes sp.2 r1128 Phyre2 PDB 1t17 chain A Region: 1 - 146 Aligned: 144 Modelled: 145 Confidence: 99.9% Identity: 16% Fold: TBP-like Superfamily: Bet v1-like Family: oligoketide cyclase/dehydrase-like Phyre2 PDB 2ns9 chain A domain 1 Region: 1 - 142 Aligned: 141 Modelled: 142 Confidence: 99.9% Identity: 12% Fold: TBP-like Superfamily: Bet v1-like Family: CoxG-like Phyre2 PDB 2le1 chain A Region: 1 - 143 Aligned: 142 Modelled: 143 Confidence: 99.9% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of tfu_2981 from thermobifida fusca, northeast2 structural genomics consortium target tfr85a Phyre2 PDB 2pcs chain A domain 1 Region: 4 - 142 Aligned: 139 Modelled: 139 Confidence: 99.9% Identity: 12% Fold: TBP-like Superfamily: Bet v1-like Family: CoxG-like Phyre2 PDB 5wox chain A Region: 1 - 141 Aligned: 138 Modelled: 141 Confidence: 99.9% Identity: 17% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: nmr solution structure of kany protein (ms6282) using two 4d-spectra Phyre2 PDB 3p9v chain A Region: 1 - 142 Aligned: 142 Modelled: 142 Confidence: 99.9% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: high resolution crystal structure of protein maqu_3174 from2 marinobacter aquaeolei, northeast structural genomics consortium3 target mqr197 Phyre2 PDB 4xrw chain A Region: 1 - 147 Aligned: 144 Modelled: 147 Confidence: 99.9% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:bexl; PDBTitle: crystal structure of the di-domain aro/cyc bexl from the be-7585a2 biosynthetic pathway Phyre2 PDB 4n0g chain C Region: 4 - 143 Aligned: 138 Modelled: 140 Confidence: 99.8% Identity: 12% PDB header:hydrolase/receptor Chain: C: PDB Molecule:abscisic acid receptor pyl13; PDBTitle: crystal structure of pyl13-pp2ca complex Phyre2 PDB 4xrt chain B Region: 3 - 144 Aligned: 142 Modelled: 142 Confidence: 99.8% Identity: 8% PDB header:lyase Chain: B: PDB Molecule:stfq aromatase/cyclase; PDBTitle: crystal structure of the di-domain aro/cyc stfq from the steffimycin2 biosynthetic pathway Phyre2 PDB 2b79 chain A domain 1 Region: 4 - 141 Aligned: 133 Modelled: 138 Confidence: 99.8% Identity: 11% Fold: TBP-like Superfamily: Bet v1-like Family: Smu440-like Phyre2 PDB 3cnw chain A domain 1 Region: 4 - 141 Aligned: 132 Modelled: 138 Confidence: 99.8% Identity: 17% Fold: TBP-like Superfamily: Bet v1-like Family: Atu1531-like Phyre2 PDB 2m47 chain A Region: 1 - 147 Aligned: 145 Modelled: 147 Confidence: 99.8% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein cgl2373; PDBTitle: solution nmr structure of the polyketide_cyc-like protein cgl2372 from2 corynebacterium glutamicum, northeast structural genomics consortium3 target cgr160 Phyre2 PDB 5vgl chain A Region: 5 - 144 Aligned: 136 Modelled: 140 Confidence: 99.7% Identity: 11% PDB header:isomerase Chain: A: PDB Molecule:lachrymatory-factor synthase; PDBTitle: crystal structure of lachrymatory factor synthase from allium cepa Phyre2 PDB 3p51 chain A Region: 4 - 145 Aligned: 135 Modelled: 142 Confidence: 99.7% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: three-dimensional structure of protein q2y8n9_nitmu from nitrosospira2 multiformis, northeast structural genomics consortium target nmr118 Phyre2 PDB 2kcz chain A Region: 1 - 146 Aligned: 144 Modelled: 146 Confidence: 99.7% Identity: 12% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein dr_a0006; PDBTitle: solution nmr structure of the c-terminal domain of protein2 dr_a0006 from deinococcus radiodurans. northeast3 structural genomics consortium target drr147d Phyre2 1 c2kf2A_ 2 d2rera1 3 c5z8oA_ 4 d2d4ra1 5 c3tfzB_ 6 d1t17a_ 7 d2ns9a1 8 c2le1A_ 9 d2pcsa1 10 c5woxA_ 11 c3p9vA_ 12 c4xrwA_ 13 c4n0gC_ 14 c4xrtB_ 15 d2b79a1 16 d3cnwa1 17 c2m47A_ 18 c5vglA_ 19 c3p51A_ 20 c2kczA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103