1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	I	G	V	G	V	C	T	T	P	D	A	R	Q	A	A	V	E	A	A	G	Q	A	R	D	E	L	A	G	E	A	P	S	L	A	V	L	L	G	S	R	A	H	T	D	R	A	A	D	V	L	S	A	V	L	Q	M	I	D
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	P	A	L	V	G	C	I	A	Q	A	I	V	A	G	R	H	E	I	E	D	E	P	A	V	V	V	W	L	A	S	G	L	A	A	E	T	F	Q	L	D	F	V	R	T	G	S	G	A	L	I	T	G	Y	R	F	D	R	T	A
Secondary structure
SS confidence
Disorder																																?		?		?									?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	D	L	H	L	L	L	P	D	P	Y	T	F	P	S	N	L	L	I	E	H	P	N	T	D	L	P	G	T	A	V	V	G	G	V	V	S	G	G	R	R	R	G	D	T	R	L	F	R	D	H	D	V	L	T	S	G	V	V	G
Secondary structure
SS confidence
Disorder																																						?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	R	L	P	G	M	R	G	V	P	V	V	S	Q	G	C	R	P	I	G	Y	P	Y	I	V	T	G	A	D	G	I	L	I	T	E	L	G	G	R	P	P	L	Q	R	L	R	E	I	V	E	G	L	S	P	D	E	R	A	L	V
Secondary structure
SS confidence
Disorder																																																									?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	H	G	L	Q	I	G	I	V	V	D	E	H	L	A	A	P	G	Q	G	D	F	V	I	R	G	L	L	G	A	D	P	S	T	G	S	I	E	I	D	E	V	V	Q	V	G	A	T	M	Q	F	Q	V	R	D	A	A	G	A	D
Secondary structure
SS confidence
Disorder		?	?	?							?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	D	L	R	L	T	V	E	R	A	A	A	R	L	P	G	R	A	A	G	A	L	L	F	T	C	N	G	R	G	R	R	M	F	G	V	A	D	H	D	A	S	T	I	E	E	L	L	G	G	I	P	L	A	G	F	F	A	A	G
Secondary structure
SS confidence
Disorder														?																				?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.
Sequence		E	I	G	P	I	A	G	R	N	A	L	H	G	F	T	A	S	M	A	L	F	V	D	D	M	E
Secondary structure
SS confidence
Disorder							?																?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 24%) Beta strand ( 36%)

Rank Aligned region

PDB 1zfj chain A Region: 1 - 175 Aligned: 165 Modelled: 175 Confidence: 71.3% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:inosine monophosphate dehydrogenase; PDBTitle: inosine monophosphate dehydrogenase (impdh; ec 1.1.1.205) from2 streptococcus pyogenes Phyre2 PDB 1rq2 chain A domain 2 Region: 3 - 65 Aligned: 63 Modelled: 63 Confidence: 56.6% Identity: 14% Fold: Bacillus chorismate mutase-like Superfamily: Tubulin C-terminal domain-like Family: Tubulin, C-terminal domain Phyre2 PDB 2vap chain A domain 2 Region: 3 - 65 Aligned: 63 Modelled: 63 Confidence: 55.9% Identity: 19% Fold: Bacillus chorismate mutase-like Superfamily: Tubulin C-terminal domain-like Family: Tubulin, C-terminal domain Phyre2 PDB 1w5f chain A domain 2 Region: 3 - 65 Aligned: 63 Modelled: 63 Confidence: 52.0% Identity: 21% Fold: Bacillus chorismate mutase-like Superfamily: Tubulin C-terminal domain-like Family: Tubulin, C-terminal domain Phyre2 PDB 2zau chain B Region: 11 - 70 Aligned: 60 Modelled: 60 Confidence: 49.1% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:selenide, water dikinase; PDBTitle: crystal structure of an n-terminally truncated2 selenophosphate synthetase from aquifex aeolicus Phyre2 PDB 4lda chain F Region: 21 - 70 Aligned: 50 Modelled: 50 Confidence: 46.1% Identity: 6% PDB header:transcription Chain: F: PDB Molecule:tadz; PDBTitle: crystal structure of a chey-like protein (tadz) from pseudomonas2 aeruginosa pao1 at 2.70 a resolution Phyre2 PDB 2ayx chain A Region: 22 - 71 Aligned: 49 Modelled: 50 Confidence: 45.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:sensor kinase protein rcsc; PDBTitle: solution structure of the e.coli rcsc c-terminus (residues2 700-949) containing linker region and phosphoreceiver3 domain Phyre2 PDB 3b2n chain A Region: 21 - 71 Aligned: 50 Modelled: 51 Confidence: 42.5% Identity: 10% PDB header:transcription Chain: A: PDB Molecule:uncharacterized protein q99uf4; PDBTitle: crystal structure of dna-binding response regulator, luxr family, from2 staphylococcus aureus Phyre2 PDB 1ny5 chain A Region: 21 - 71 Aligned: 50 Modelled: 51 Confidence: 37.9% Identity: 8% PDB header:transcription Chain: A: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of sigm54 activator (aaa+ atpase) in the inactive2 state Phyre2 PDB 6ifh chain A Region: 21 - 69 Aligned: 48 Modelled: 49 Confidence: 36.8% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:sporulation initiation phosphotransferase f; PDBTitle: unphosphorylated spo0f from paenisporosarcina sp. tg-14 Phyre2 PDB 4r3u chain D Region: 21 - 71 Aligned: 51 Modelled: 51 Confidence: 36.5% Identity: 6% PDB header:isomerase Chain: D: PDB Molecule:2-hydroxyisobutyryl-coa mutase small subunit; PDBTitle: crystal structure of 2-hydroxyisobutyryl-coa mutase Phyre2 PDB 4z87 chain B Region: 1 - 175 Aligned: 165 Modelled: 175 Confidence: 35.8% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:inosine-5'-monophosphate dehydrogenase; PDBTitle: structure of the imp dehydrogenase from ashbya gossypii bound to gdp Phyre2 PDB 5uic chain A Region: 21 - 69 Aligned: 48 Modelled: 49 Confidence: 34.9% Identity: 13% PDB header:transcription Chain: A: PDB Molecule:two-component response regulator; PDBTitle: structure of the francisella response regulator receiver domain, qseb Phyre2 PDB 5ep0 chain A Region: 21 - 71 Aligned: 50 Modelled: 51 Confidence: 32.0% Identity: 18% PDB header:transcription Chain: A: PDB Molecule:putative repressor protein luxo; PDBTitle: quorum-sensing signal integrator luxo - receiver+catalytic domains Phyre2 PDB 5lwk chain B Region: 21 - 71 Aligned: 50 Modelled: 51 Confidence: 30.7% Identity: 16% PDB header:transcription Chain: B: PDB Molecule:transcriptional regulatory protein; PDBTitle: maer response regulator bound to beryllium trifluoride Phyre2 PDB 1ys7 chain A domain 2 Region: 21 - 69 Aligned: 48 Modelled: 49 Confidence: 30.0% Identity: 19% Fold: Flavodoxin-like Superfamily: CheY-like Family: CheY-related Phyre2 PDB 3hv2 chain B Region: 21 - 71 Aligned: 50 Modelled: 51 Confidence: 27.9% Identity: 18% PDB header:signaling protein Chain: B: PDB Molecule:response regulator/hd domain protein; PDBTitle: crystal structure of signal receiver domain of hd domain-containing2 protein from pseudomonas fluorescens pf-5 Phyre2 PDB 1g2o chain A Region: 12 - 41 Aligned: 30 Modelled: 30 Confidence: 27.8% Identity: 33% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 3cu5 chain B Region: 21 - 71 Aligned: 50 Modelled: 51 Confidence: 27.5% Identity: 8% PDB header:transcription regulator Chain: B: PDB Molecule:two component transcriptional regulator, arac family; PDBTitle: crystal structure of a two component transcriptional regulator arac2 from clostridium phytofermentans isdg Phyre2 PDB 1pey chain A Region: 21 - 71 Aligned: 50 Modelled: 51 Confidence: 27.2% Identity: 20% Fold: Flavodoxin-like Superfamily: CheY-like Family: CheY-related Phyre2 1 c1zfjA_ 2 d1rq2a2 3 d2vapa2 4 d1w5fa2 5 c2zauB_ 6 c4ldaF_ 7 c2ayxA_ 8 c3b2nA_ 9 c1ny5A_ 10 c6ifhA_ 11 c4r3uD_ 12 c4z87B_ 13 c5uicA_ 14 c5ep0A_ 15 c5lwkB_ 16 d1ys7a2 17 c3hv2B_ 18 d1g2oa_ 19 c3cu5B_ 20 d1peya_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99