1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	E	G	R	C	A	Q	H	P	D	G	L	D	V	Q	D	V	C	D	P	D	D	P	R	L	D	D	F	R	D	L	N	S	I	D	R	R	P	D	L	P	T	G	K	A	L	V	I	A	E	G	V	L	V	V	Q	R	M	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																												?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	S	R	F	T	P	L	A	L	F	G	T	D	R	R	L	A	E	L	K	D	D	L	A	G	V	G	A	P	Y	Y	R	A	S	A	D	V	M	A	R	V	I	G	F	H	L	N	R	G	V	L	A	A	A	G	R	V	P	E	P
Secondary structure
SS confidence
Disorder																																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	V	A	Q	V	V	A	G	A	R	T	V	A	V	L	E	G	V	N	D	H	E	N	L	G	S	I	F	R	N	A	A	G	L	S	V	D	A	V	V	F	G	T	G	C	A	D	P	L	Y	R	R	A	V	R	V	S	M	G	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	L	L	V	P	Y	A	R	A	A	D	W	P	T	E	L	M	T	L	K	E	S	G	F	R	L	L	A	M	T	P	H	G	N	A	C	K	L	P	E	A	I	A	A	V	S	H	E	R	I	A	L	L	V	G	A	E	G	P	G
Secondary structure
SS confidence
Disorder																																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.
Sequence		L	T	A	A	A	L	R	I	S	D	V	R	V	R	I	P	M	S	R	G	T	D	S	L	N	V	A	T	A	A	A	L	A	F	Y	E	R	T	R	S	G	H	H	I	G	P	G	T
Secondary structure
SS confidence
Disorder																																									?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 40%) Beta strand ( 20%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 1ipa chain A Region: 15 - 282 Aligned: 257 Modelled: 257 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:rna 2'-o-ribose methyltransferase; PDBTitle: crystal structure of rna 2'-o ribose methyltransferase Phyre2 PDB 5kzk chain A Region: 14 - 284 Aligned: 261 Modelled: 256 Confidence: 100.0% Identity: 22% PDB header:rna binding protein Chain: A: PDB Molecule:probable rna methyltransferase, trmh family; PDBTitle: crystal structure of rrna methyltransferase from sinorhizobium2 meliloti Phyre2 PDB 4x3m chain B Region: 17 - 286 Aligned: 258 Modelled: 258 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: B: PDB Molecule:rna 2'-o ribose methyltransferase; PDBTitle: crystal structure of ttha0275 from thermus thermophilus (hb8) in2 complex with adenosine in space group p212121 Phyre2 PDB 2i6d chain A Region: 19 - 281 Aligned: 250 Modelled: 244 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:rna methyltransferase, trmh family; PDBTitle: the structure of a putative rna methyltransferase of the trmh family2 from porphyromonas gingivalis. Phyre2 PDB 3gyq chain B Region: 19 - 281 Aligned: 254 Modelled: 254 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:rrna (adenosine-2'-o-)-methyltransferase; PDBTitle: structure of the thiostrepton-resistance methyltransferase2 s-adenosyl-l-methionine complex Phyre2 PDB 1x7p chain B Region: 23 - 281 Aligned: 245 Modelled: 245 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:rrna methyltransferase; PDBTitle: crystal structure of the spou methyltransferase avirb from2 streptomyces viridochromogenes in complex with the cofactor adomet Phyre2 PDB 1gz0 chain H Region: 41 - 281 Aligned: 236 Modelled: 241 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: H: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb Phyre2 PDB 1gz0 chain A domain 1 Region: 115 - 281 Aligned: 163 Modelled: 167 Confidence: 100.0% Identity: 25% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 1gz0 chain G Region: 115 - 281 Aligned: 163 Modelled: 156 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: G: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb Phyre2 PDB 1zjr chain A Region: 127 - 287 Aligned: 157 Modelled: 157 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:trna (guanosine-2'-o-)-methyltransferase; PDBTitle: crystal structure of a. aeolicus trmh/spou trna modifying enzyme Phyre2 PDB 1v2x chain A Region: 127 - 282 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 27% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 5co4 chain A Region: 128 - 282 Aligned: 149 Modelled: 149 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:putative trna (cytidine(34)-2'-o)-methyltransferase; PDBTitle: structural insights into the 2-oh methylation of c/u34 on trna Phyre2 PDB 1ipa chain A domain 1 Region: 127 - 282 Aligned: 150 Modelled: 150 Confidence: 100.0% Identity: 34% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 4pzk chain A Region: 130 - 288 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:trna (cytidine(34)-2'-o)-methyltransferase; PDBTitle: crystal strucrure of putative rna methyltransferase from bacillus2 anthracis. Phyre2 PDB 2ha8 chain A Region: 126 - 282 Aligned: 153 Modelled: 153 Confidence: 100.0% Identity: 23% PDB header:rna binding protein Chain: A: PDB Molecule:tar (hiv-1) rna loop binding protein; PDBTitle: methyltransferase domain of human tar (hiv-1) rna binding2 protein 1 Phyre2 PDB 3onp chain A Region: 130 - 280 Aligned: 148 Modelled: 151 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:trna/rrna methyltransferase (spou); PDBTitle: crystal structure of trna/rrna methyltransferase spou from rhodobacter2 sphaeroides Phyre2 PDB 1mxi chain A Region: 131 - 285 Aligned: 149 Modelled: 149 Confidence: 100.0% Identity: 20% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 5gm8 chain A Region: 129 - 280 Aligned: 148 Modelled: 148 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:trna (cytidine/uridine-2'-o-)-methyltransferase trmj; PDBTitle: methylation at position 32 of trna catalyzed by trmj alters oxidative2 stress response in pseudomonas aeruiginosa Phyre2 PDB 3ic6 chain A Region: 129 - 282 Aligned: 150 Modelled: 151 Confidence: 100.0% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative methylase family protein; PDBTitle: crystal structure of putative methylase family protein from neisseria2 gonorrhoeae Phyre2 PDB 4cng chain B Region: 130 - 279 Aligned: 146 Modelled: 146 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:spou rrna methylase; PDBTitle: crystal structure of sulfolobus acidocaldarius trmj in2 complex with s-adenosyl-l-homocysteine Phyre2 1 c1ipaA_ 2 c5kzkA_ 3 c4x3mB_ 4 c2i6dA_ 5 c3gyqB_ 6 c1x7pB_ 7 c1gz0H_ 8 d1gz0a1 9 c1gz0G_ 10 c1zjrA_ 11 d1v2xa_ 12 c5co4A_ 13 d1ipaa1 14 c4pzkA_ 15 c2ha8A_ 16 c3onpA_ 17 d1mxia_ 18 c5gm8A_ 19 c3ic6A_ 20 c4cngB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104