1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	R	T	R	I	V	R	R	W	R	R	N	M	D	V	A	D	D	A	E	Y	V	E	M	L	A	T	L	S	E	G	S	V	R	R	N	F	N	P	Y	T	D	I	D	W	E	S	P	E	F	A	V	T	D	N	D	P	R	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?																		?	?	?												?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	L	P	A	T	D	P	L	G	R	H	P	W	Y	Q	A	Q	S	R	E	R	Q	I	E	I	G	M	W	R	Q	A	N	V	A	K	V	G	L	H	F	E	S	I	L	I	R	G	L	M	N	Y	T	F	W	M	P	N	G	S	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	Y	R	Y	C	L	H	E	S	V	E	E	C	N	H	T	M	M	F	Q	E	M	V	N	R	V	G	A	D	V	P	G	L	P	R	R	L	R	W	V	S	P	L	V	P	L	V	A	G	P	L	P	V	A	F	F	I	G	V	L
Secondary structure
SS confidence
Disorder																														?																?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	G	E	E	P	I	D	H	T	Q	K	N	V	L	R	E	G	K	S	L	H	P	I	M	E	R	V	M	S	I	H	V	A	E	E	A	R	H	I	S	F	A	H	E	Y	L	R	K	R	L	P	R	L	T	R	M	Q	R	F	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	S	L	Y	F	P	L	T	M	R	S	L	C	N	A	I	V	V	P	P	K	A	F	W	E	E	F	D	I	P	R	E	V	K	K	E	L	F	F	G	S	P	E	S	R	K	W	L	C	D	M	F	A	D	A	R	M	L	A	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340
Sequence		D	T	G	L	M	N	P	I	A	R	L	V	W	R	L	C	K	I	D	G	K	P	S	R	Y	R	S	E	P	Q	R	Q	H	L	A	A	A	P	A	A
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 68%) Beta strand ( 1%) TM helix ( 15%) (View membrane topology prediction)

Rank Aligned region

PDB 5hyh chain A Region: 25 - 308 Aligned: 268 Modelled: 281 Confidence: 100.0% Identity: 13% PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: cmli (chemically reduced state), arylamine oxygenase of2 chloramphenicol biosynthetic pathway Phyre2 PDB 3cht chain A Region: 25 - 314 Aligned: 273 Modelled: 277 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:p-aminobenzoate n-oxygenase; PDBTitle: crystal structure of di-iron aurf with partially bound ligand Phyre2 PDB 6d9f chain A Region: 40 - 244 Aligned: 201 Modelled: 205 Confidence: 99.9% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:putative vlmb homolog; PDBTitle: protein 60 with aldehyde deformylating oxidase activity from2 kitasatospora setae Phyre2 PDB 5uxg chain B Region: 74 - 279 Aligned: 189 Modelled: 206 Confidence: 99.3% Identity: 15% PDB header:lyase Chain: B: PDB Molecule:aldehyde deformylating oxygenase; PDBTitle: protein 84 with aldehyde deformylating oxygenase activity from2 sulfolobus tokodaii (monoclinic) Phyre2 PDB 3dhz chain A domain 1 Region: 39 - 300 Aligned: 242 Modelled: 262 Confidence: 99.3% Identity: 9% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1uzr chain A Region: 59 - 253 Aligned: 189 Modelled: 195 Confidence: 99.2% Identity: 8% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 4n83 chain F Region: 59 - 300 Aligned: 226 Modelled: 242 Confidence: 99.2% Identity: 8% PDB header:oxidoreductase Chain: F: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: x-ray crystal structure of streptococcus sanguinis dimanganese(ii)-2 nrdf Phyre2 PDB 1r2f chain B Region: 59 - 253 Aligned: 190 Modelled: 195 Confidence: 99.1% Identity: 12% PDB header:oxidoreductase Chain: B: PDB Molecule:protein (ribonucleotide reductase r2); PDBTitle: ribonucleotide reductase r2f protein from salmonella2 typhimurium Phyre2 PDB 1r2f chain A Region: 59 - 253 Aligned: 190 Modelled: 195 Confidence: 99.1% Identity: 12% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 4dr0 chain A Region: 59 - 300 Aligned: 226 Modelled: 242 Confidence: 99.1% Identity: 9% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of bacillus subtilis dimanganese(ii) nrdf Phyre2 PDB 4hr0 chain A Region: 59 - 252 Aligned: 189 Modelled: 194 Confidence: 99.0% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonuleotide reductase small subunit; PDBTitle: r2-like ligand-binding oxidase with aerobically reconstituted metal2 cofactor Phyre2 PDB 4bmt chain B Region: 59 - 253 Aligned: 190 Modelled: 195 Confidence: 99.0% Identity: 12% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of ribonucleotide reductase di-iron nrdf2 from bacillus cereus Phyre2 PDB 1oqu chain C Region: 34 - 253 Aligned: 210 Modelled: 220 Confidence: 99.0% Identity: 10% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1mty chain D Region: 33 - 249 Aligned: 211 Modelled: 212 Confidence: 99.0% Identity: 12% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1h0o chain A Region: 59 - 278 Aligned: 208 Modelled: 220 Confidence: 99.0% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: cobalt substitution of mouse r2 ribonucleotide reductase to2 model the reactive diferrous state Phyre2 PDB 1w68 chain A Region: 59 - 278 Aligned: 207 Modelled: 220 Confidence: 99.0% Identity: 14% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1mhy chain D Region: 65 - 249 Aligned: 176 Modelled: 180 Confidence: 99.0% Identity: 13% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 3ee4 chain A Region: 59 - 252 Aligned: 191 Modelled: 194 Confidence: 98.9% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:probable ribonucleoside-diphosphate reductase; PDBTitle: r2-like ligand binding mn/fe oxidase from m. tuberculosis Phyre2 PDB 2inc chain A domain 1 Region: 84 - 323 Aligned: 229 Modelled: 240 Confidence: 98.9% Identity: 10% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 6qrz chain A Region: 26 - 232 Aligned: 180 Modelled: 194 Confidence: 98.9% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: crystal structure of r2-like ligand-binding oxidase from sulfolobus2 acidocaldarius solved by 3d micro-crystal electron diffraction Phyre2 1 c5hyhA_ 2 c3chtA_ 3 c6d9fA_ 4 c5uxgB_ 5 d3dhza1 6 d1uzra_ 7 c4n83F_ 8 c1r2fB_ 9 d1r2fa_ 10 c4dr0A_ 11 c4hr0A_ 12 c4bmtB_ 13 d1oquc_ 14 d1mtyd_ 15 c1h0oA_ 16 d1w68a_ 17 d1mhyd_ 18 c3ee4A_ 19 d2inca1 20 c6qrzA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113