1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	Y	A	K	R	I	G	Q	V	G	A	L	A	V	V	L	G	V	G	A	A	V	T	T	H	A	I	G	S	A	A	P	T	D	P	S	S	S	S	T	D	S	P	V	D	A	C	S	P	L	G	G	S	A	S	S	L	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?				?	?							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?				?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	P	G	A	S	V	P	Q	V	G	V	R	Q	V	D	P	G	S	I	P	D	D	L	L	N	A	L	I	D	F	L	A	A	V	R	N	G	L	V	P	I	I	E	N	R	T	P	V	A	N	P	Q	Q	V	S	V	P	E	G	G
Secondary structure
SS confidence
Disorder		?																						?		?	?	?	?	?	?	?	?	?	?	?	?																?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	V	G	P	V	R	F	D	A	C	D	P	D	G	N	R	M	T	F	A	V	R	E	R	G	A	P	G	G	P	Q	H	G	I	V	T	V	D	Q	R	T	A	S	F	I	Y	T	A	D	P	G	F	V	G	T	D	T	F	S	V
Secondary structure
SS confidence
Disorder		?	?	?					?														?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	V	S	D	D	T	S	L	H	V	H	G	L	A	G	Y	L	G	P	F	H	G	H	D	D	V	A	T	V	T	V	F	V	G	N	T	P	T	D	T	I	S	G	D	F	S	M	L	T	Y	N	I	A	G	L	P	F	P	L	S
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?										?		?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?										?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	A	I	L	P	R	F	F	Y	T	K	E	I	G	K	R	L	N	A	Y	Y	V	A	N	V	Q	E	D	F	A	Y	H	Q	F	L	I	K	K	S	K	M	P	S	Q	T	P	P	E	P	P	T	L	L	W	P	I	G	V	P	F
Secondary structure
SS confidence
Disorder		?	?	?		?																																														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	D	G	L	N	T	L	S	E	F	K	V	Q	R	L	D	R	Q	T	W	Y	E	C	T	S	D	N	C	L	T	L	K	G	F	T	Y	S	Q	M	R	L	P	G	G	D	T	V	D	V	Y	N	L	H	T	N	T	G	G	G	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		T	T	N	A	N	L	A	Q	V	A	N	Y	I	Q	Q	N	S	A	G	R	A	V	I	V	T	G	D	F	N	A	R	Y	S	D	D	Q	S	A	L	L	Q	F	A	Q	V	N	G	L	T	D	A	W	V	Q	V	E	H	G	P	T
Secondary structure
SS confidence
Disorder																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		T	P	P	F	A	P	T	C	M	V	G	N	E	C	E	L	L	D	K	I	F	Y	R	S	G	Q	G	V	T	L	Q	A	V	S	Y	G	N	E	A	P	K	F	F	N	S	K	G	E	P	L	S	D	H	S	P	A	V	V	G	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490
Sequence		H	Y	V	A	D	N	V	A	V	R
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 11%) Beta strand ( 37%)

Rank Aligned region

PDB 5uvg chain A Region: 223 - 483 Aligned: 252 Modelled: 261 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:sphingomyelin phosphodiesterase 3,sphingomyelin PDBTitle: crystal structure of the human neutral sphingomyelinase 2 (nsmase2)2 catalytic domain with insertion deleted and calcium bound Phyre2 PDB 4ruw chain A Region: 224 - 490 Aligned: 253 Modelled: 267 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease/exonuclease/phosphatase; PDBTitle: the crystal structure of endonuclease/exonuclease/phosphatase from2 beutenbergia cavernae dsm 12333 Phyre2 PDB 4f1i chain A Region: 224 - 481 Aligned: 229 Modelled: 251 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:5'-tyrosyl-dna phosphodiesterase; PDBTitle: crystal structure of semet tdp2 from caenorhabditis elegans Phyre2 PDB 1zwx chain A domain 1 Region: 223 - 480 Aligned: 254 Modelled: 258 Confidence: 99.9% Identity: 16% Fold: DNase I-like Superfamily: DNase I-like Family: Sphingomyelin phosphodiesterase-like Phyre2 PDB 3wcx chain A Region: 222 - 481 Aligned: 256 Modelled: 260 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:sphingomyelinase c; PDBTitle: crystal structure of sphingomyelinase c from streptomyces2 griseocarneus Phyre2 PDB 4f1h chain A Region: 224 - 481 Aligned: 236 Modelled: 258 Confidence: 99.9% Identity: 19% PDB header:hydrolase/dna Chain: A: PDB Molecule:tyrosyl-dna phosphodiesterase 2; PDBTitle: crystal structure of tdp2 from danio rerio complexed with a single2 strand dna Phyre2 PDB 2imq chain X domain 1 Region: 224 - 482 Aligned: 232 Modelled: 259 Confidence: 99.9% Identity: 17% Fold: DNase I-like Superfamily: DNase I-like Family: Inositol polyphosphate 5-phosphatase (IPP5) Phyre2 PDB 3teb chain A Region: 227 - 482 Aligned: 234 Modelled: 256 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease/exonuclease/phosphatase; PDBTitle: endonuclease/exonuclease/phosphatase family protein from leptotrichia2 buccalis c-1013-b Phyre2 PDB 2ddr chain A domain 1 Region: 222 - 481 Aligned: 254 Modelled: 260 Confidence: 99.9% Identity: 16% Fold: DNase I-like Superfamily: DNase I-like Family: Sphingomyelin phosphodiesterase-like Phyre2 PDB 3i46 chain B Region: 224 - 480 Aligned: 253 Modelled: 257 Confidence: 99.9% Identity: 17% PDB header:toxin Chain: B: PDB Molecule:beta-hemolysin; PDBTitle: crystal structure of beta toxin from staphylococcus aureus f277a,2 p278a mutant with bound calcium ions Phyre2 PDB 3mpr chain B Region: 223 - 482 Aligned: 256 Modelled: 260 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:putative endonuclease/exonuclease/phosphatase family PDBTitle: crystal structure of endonuclease/exonuclease/phosphatase family2 protein from bacteroides thetaiotaomicron, northeast structural3 genomics consortium target btr318a Phyre2 PDB 3mtc chain A Region: 224 - 482 Aligned: 233 Modelled: 256 Confidence: 99.9% Identity: 19% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:type ii inositol-1,4,5-trisphosphate 5-phosphatase; PDBTitle: crystal structure of inpp5b in complex with phosphatidylinositol 4-2 phosphate Phyre2 PDB 4fva chain D Region: 224 - 481 Aligned: 235 Modelled: 258 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:5'-tyrosyl-dna phosphodiesterase; PDBTitle: crystal structure of truncated caenorhabditis elegans tdp2 Phyre2 PDB 4gz1 chain B Region: 224 - 483 Aligned: 239 Modelled: 260 Confidence: 99.9% Identity: 18% PDB header:hydrolase/dna Chain: B: PDB Molecule:tyrosyl-dna phosphodiesterase 2; PDBTitle: mus musculus tdp2 reaction product (5'-phosphorylated dna)-mg2+2 complex at 1.5 angstroms resolution Phyre2 PDB 6bt2 chain B Region: 215 - 483 Aligned: 252 Modelled: 262 Confidence: 99.9% Identity: 17% PDB header:hydrolase, rna binding protein Chain: B: PDB Molecule:nocturnin; PDBTitle: structure of the human nocturnin catalytic domain with bound sulfate2 anion Phyre2 PDB 3g6s chain A Region: 223 - 482 Aligned: 244 Modelled: 260 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:putative endonuclease/exonuclease/phosphatase family PDBTitle: crystal structure of the endonuclease/exonuclease/phosphatase2 (bvu_0621) from bacteroides vulgatus. northeast structural genomics3 consortium target bvr56d Phyre2 PDB 3nr8 chain A Region: 224 - 486 Aligned: 242 Modelled: 263 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; PDBTitle: crystal structure of human ship2 Phyre2 PDB 3ngo chain A Region: 215 - 484 Aligned: 265 Modelled: 269 Confidence: 99.9% Identity: 13% PDB header:hydrolase/dna Chain: A: PDB Molecule:ccr4-not transcription complex subunit 6-like; PDBTitle: crystal structure of the human cnot6l nuclease domain in complex with2 poly(a) dna Phyre2 PDB 3l1w chain E Region: 227 - 482 Aligned: 236 Modelled: 256 Confidence: 99.9% Identity: 15% PDB header:structural genomics, unknown function Chain: E: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of a functionally unknown conserved2 protein from enterococcus faecalis v583 Phyre2 PDB 1sr4 chain B Region: 224 - 481 Aligned: 234 Modelled: 258 Confidence: 99.9% Identity: 15% Fold: DNase I-like Superfamily: DNase I-like Family: DNase I-like Phyre2 1 c5uvgA_ 2 c4ruwA_ 3 c4f1iA_ 4 d1zwxa1 5 c3wcxA_ 6 c4f1hA_ 7 d2imqx1 8 c3tebA_ 9 d2ddra1 10 c3i46B_ 11 c3mprB_ 12 c3mtcA_ 13 c4fvaD_ 14 c4gz1B_ 15 c6bt2B_ 16 c3g6sA_ 17 c3nr8A_ 18 c3ngoA_ 19 c3l1wE_ 20 d1sr4b_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103