1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	Q	Q	Q	E	A	D	V	V	A	L	G	R	K	P	G	L	L	C	V	P	E	R	F	R	A	M	D	L	P	M	A	A	A	D	A	L	F	L	W	A	E	T	P	T	R	P	L	H	V	G	A	L	A	V	L	S	Q	P
Secondary structure
SS confidence
Disorder		?	?	?	?							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	N	G	T	G	R	Y	L	R	K	V	F	S	A	A	V	A	R	Q	Q	V	A	P	W	W	R	R	R	P	H	R	S	L	T	S	L	G	Q	W	S	W	R	T	E	T	E	V	D	L	D	Y	H	V	R	L	S	A	L	P	P
Secondary structure
SS confidence
Disorder																																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	A	G	T	A	E	L	W	A	L	V	S	E	L	H	A	G	M	L	D	R	S	R	P	L	W	Q	V	D	L	I	E	G	L	P	G	G	R	C	A	V	Y	V	K	V	H	H	A	L	A	D	G	V	S	V	M	R	L	L	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	I	V	T	A	D	P	H	Q	R	Q	M	P	T	L	W	E	V	P	A	Q	A	S	V	A	K	H	T	A	P	R	G	S	S	R	P	L	T	L	A	K	G	V	L	G	Q	A	R	G	V	P	G	M	V	R	V	V	A	D	T
Secondary structure
SS confidence
Disorder											?	?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	W	R	A	A	Q	C	R	S	G	P	L	T	L	A	A	P	H	T	P	L	N	E	P	I	A	G	A	R	S	V	A	G	C	S	F	P	I	E	R	L	R	Q	V	A	E	H	A	D	A	T	I	N	D	V	V	L	A	M	C
Secondary structure
SS confidence
Disorder									?		?	?	?	?	?	?	?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	G	A	L	R	A	Y	L	I	S	R	G	A	L	P	G	A	P	L	I	A	M	V	P	V	S	L	R	D	T	A	V	I	D	V	F	G	Q	G	P	G	N	K	I	G	T	L	M	C	S	L	A	T	H	L	A	S	P	V	E
Secondary structure
SS confidence
Disorder																														?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	L	S	A	I	R	A	S	M	R	D	G	K	A	A	I	A	G	R	S	R	N	Q	A	L	A	M	S	A	L	G	A	A	P	L	A	L	A	M	A	L	G	R	V	P	A	P	L	R	P	P	N	V	T	I	S	N	V	P	G
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?									?	?	?	?											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	Q	G	A	L	Y	W	N	G	A	R	L	D	A	L	Y	L	L	S	A	P	V	D	G	A	A	L	N	I	T	C	S	G	T	N	E	Q	I	T	F	G	L	T	G	C	R	R	A	V	P	A	L	S	I	L	T	D	Q	L	A
Secondary structure
SS confidence
Disorder																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.
Sequence		H	E	L	E	L	L	V	G	V	S	E	A	G	P	G	T	R	L	R	R	I	A	G	R	R
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 40%) Beta strand ( 18%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 6chj chain B Region: 31 - 491 Aligned: 408 Modelled: 416 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: B: PDB Molecule:diacylglycerol o-acyltransferase; PDBTitle: wax ester synthase/diacylglycerol acyltransferase from marinobacter2 aquaeolei vt8 Phyre2 PDB 4zxi chain A Region: 30 - 502 Aligned: 424 Modelled: 457 Confidence: 100.0% Identity: 12% PDB header:biosynthetic protein Chain: A: PDB Molecule:tyrocidine synthetase 3; PDBTitle: crystal structure of holo-ab3403 a four domain nonribosomal peptide2 synthetase bound to amp and glycine Phyre2 PDB 2vsq chain A Region: 30 - 501 Aligned: 420 Modelled: 443 Confidence: 100.0% Identity: 11% PDB header:ligase Chain: A: PDB Molecule:surfactin synthetase subunit 3; PDBTitle: structure of surfactin a synthetase c (srfa-c), a nonribosomal peptide2 synthetase termination module Phyre2 PDB 5t81 chain A Region: 7 - 493 Aligned: 441 Modelled: 459 Confidence: 100.0% Identity: 14% PDB header:biosynthetic protein Chain: A: PDB Molecule:epob; PDBTitle: rhombohedral crystal form of the epob nrps cyclization-docking2 bidomain from sorangium cellulosum Phyre2 PDB 5m6p chain B Region: 29 - 493 Aligned: 427 Modelled: 427 Confidence: 100.0% Identity: 13% PDB header:isomerase Chain: B: PDB Molecule:tyrocidine synthase 2; PDBTitle: crystal structure of the epimerization domain from module 3 of2 tyrocidine synthetase b, tycb3(e) Phyre2 PDB 5u89 chain A Region: 22 - 501 Aligned: 422 Modelled: 461 Confidence: 100.0% Identity: 15% PDB header:hydrolase/inhibitor Chain: A: PDB Molecule:amino acid adenylation domain protein; PDBTitle: crystal structure of a cross-module fragment from the dimodular nrps2 dhbf Phyre2 PDB 5t3e chain A Region: 29 - 496 Aligned: 423 Modelled: 452 Confidence: 100.0% Identity: 14% PDB header:ligase Chain: A: PDB Molecule:bacillamide synthetase heterocyclization domain; PDBTitle: crystal structure of a nonribosomal peptide synthetase2 heterocyclization domain. Phyre2 PDB 2xhg chain A Region: 29 - 491 Aligned: 424 Modelled: 463 Confidence: 100.0% Identity: 11% PDB header:isomerase Chain: A: PDB Molecule:tyrocidine synthetase a; PDBTitle: crystal structure of the epimerization domain from the initiation2 module of tyrocidine biosynthesis Phyre2 PDB 6p1j chain A Region: 30 - 502 Aligned: 426 Modelled: 473 Confidence: 100.0% Identity: 16% PDB header:biosynthetic protein Chain: A: PDB Molecule:txo2; PDBTitle: the structure of condensation and adenylation domains of teixobactin-2 producing nonribosomal peptide synthetase txo2 serine module Phyre2 PDB 6aef chain B Region: 15 - 488 Aligned: 426 Modelled: 471 Confidence: 100.0% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:polyketide synthase associated protein papa2; PDBTitle: papa2 acyl transferase Phyre2 PDB 2jgp chain A Region: 7 - 501 Aligned: 440 Modelled: 477 Confidence: 100.0% Identity: 12% PDB header:ligase Chain: A: PDB Molecule:tyrocidine synthetase 3; PDBTitle: structure of the tycc5-6 pcp-c bidomain of the tyrocidine synthetase2 tycc Phyre2 PDB 6ad3 chain A Region: 31 - 498 Aligned: 426 Modelled: 444 Confidence: 100.0% Identity: 11% PDB header:biosynthetic protein Chain: A: PDB Molecule:lovastatin nonaketide synthase moka; PDBTitle: structural characterization of the condensation domain from monacolin2 k polyketide synthase moka Phyre2 PDB 6cgo chain B Region: 20 - 487 Aligned: 425 Modelled: 450 Confidence: 100.0% Identity: 13% PDB header:biosynthetic protein Chain: B: PDB Molecule:condensation domain protein; PDBTitle: molecular basis for condensation domain-mediated chain release from2 the enacyloxin polyketide synthase Phyre2 PDB 4znm chain B Region: 31 - 499 Aligned: 423 Modelled: 443 Confidence: 100.0% Identity: 12% PDB header:ligase Chain: B: PDB Molecule:c-domain type ii peptide synthetase; PDBTitle: crystal structure of sgcc5 protein from streptomyces globisporus (apo2 form) Phyre2 PDB 4jn3 chain B Region: 27 - 501 Aligned: 422 Modelled: 433 Confidence: 100.0% Identity: 17% PDB header:biosynthetic protein Chain: B: PDB Molecule:cda peptide synthetase i; PDBTitle: crystal structures of the first condensation domain of the cda2 synthetase Phyre2 PDB 4zxj chain A Region: 29 - 501 Aligned: 423 Modelled: 446 Confidence: 100.0% Identity: 13% PDB header:biosynthetic protein Chain: A: PDB Molecule:enterobactin synthase component f; PDBTitle: crystal structure of holo-entf a nonribosomal peptide synthetase in2 the thioester-forming conformation Phyre2 PDB 5ja2 chain A Region: 42 - 501 Aligned: 404 Modelled: 421 Confidence: 100.0% Identity: 14% PDB header:ligase Chain: A: PDB Molecule:enterobactin synthase component f; PDBTitle: entf, a terminal nonribosomal peptide synthetase module bound to the2 non-native mbth-like protein pa2412 Phyre2 PDB 6m7l chain B Region: 29 - 501 Aligned: 419 Modelled: 471 Confidence: 100.0% Identity: 15% PDB header:biosynthetic protein Chain: B: PDB Molecule:putative non-ribosomal peptide synthetase; PDBTitle: complex of oxya with the x-domain from gpa biosynthesis Phyre2 PDB 4tx3 chain B Region: 11 - 501 Aligned: 443 Modelled: 488 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase Chain: B: PDB Molecule:peptide synthetase, module 7; PDBTitle: complex of the x-domain and oxyb from teicoplanin biosynthesis Phyre2 PDB 6ozv chain A Region: 31 - 501 Aligned: 403 Modelled: 441 Confidence: 100.0% Identity: 15% PDB header:biosynthetic protein Chain: A: PDB Molecule:txo1; PDBTitle: the structure of condensation and adenylation domains of teixobactin-2 producing nonribosomal peptide synthetase txo1 serine module in3 complex with amp Phyre2 1 c6chjB_ 2 c4zxiA_ 3 c2vsqA_ 4 c5t81A_ 5 c5m6pB_ 6 c5u89A_ 7 c5t3eA_ 8 c2xhgA_ 9 c6p1jA_ 10 c6aefB_ 11 c2jgpA_ 12 c6ad3A_ 13 c6cgoB_ 14 c4znmB_ 15 c4jn3B_ 16 c4zxjA_ 17 c5ja2A_ 18 c6m7lB_ 19 c4tx3B_ 20 c6ozvA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68