1

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.

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.

.

.

.

.

10

.

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.

.

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20

.

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30

.

.

.

.

.

.

.

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40

.

.

.

.

.

.

.

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.

50

Sequence

M

D

F

V

I

Q

W

S

C

Y

L

L

A

F

L

G

G

S

A

V

A

W

V

V

V

T

L

S

I

K

R

A

S

R

D

E

G

A

A

E

A

P

S

A

A

E

T

G

A

Q

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 48%) Alpha helix ( 24%) Beta strand ( 38%)

Rank Aligned region

PDB 5mqu chain A Region: 36 - 49 Aligned: 14 Modelled: 14 Confidence: 9.6% Identity: 57% PDB header:virus Chain: A: PDB Molecule:vp1; PDBTitle: crystal structure of bovine enterovirus 2 determined with serial2 femtosecond x-ray crystallography Phyre2 PDB 4wm8 chain A Region: 37 - 49 Aligned: 13 Modelled: 13 Confidence: 8.5% Identity: 46% PDB header:virus Chain: A: PDB Molecule:vp1; PDBTitle: crystal structure of human enterovirus d68 Phyre2 PDB 2dco chain A Region: 6 - 9 Aligned: 4 Modelled: 4 Confidence: 7.9% Identity: 100% PDB header:membrane protein Chain: A: PDB Molecule:s1p4 first extracellular loop peptidomimetic; PDBTitle: s1p4 first extracellular loop peptidomimetic Phyre2 PDB 1cov chain 1 Region: 25 - 49 Aligned: 25 Modelled: 25 Confidence: 7.0% Identity: 32% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: Positive stranded ssRNA viruses Family: Picornaviridae-like VP (VP1, VP2, VP3 and VP4) Phyre2 PDB 1z7s chain 1 Region: 37 - 49 Aligned: 13 Modelled: 13 Confidence: 7.0% Identity: 46% PDB header:virus Chain: 1: PDB Molecule:human coxsackievirus a21; PDB Fragment:viral protein 1; PDBTitle: the crystal structure of coxsackievirus a21 Phyre2 PDB 1bev chain 1 Region: 33 - 49 Aligned: 17 Modelled: 17 Confidence: 6.6% Identity: 47% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: Positive stranded ssRNA viruses Family: Picornaviridae-like VP (VP1, VP2, VP3 and VP4) Phyre2 PDB 3vbf chain A Region: 28 - 49 Aligned: 22 Modelled: 22 Confidence: 6.2% Identity: 36% PDB header:virus Chain: A: PDB Molecule:genome polyprotein, capsid protein vp1; PDBTitle: crystal structure of formaldehyde treated human enterovirus 71 (space2 group i23) Phyre2 PDB 3iz5 chain W Region: 10 - 19 Aligned: 10 Modelled: 10 Confidence: 6.0% Identity: 70% PDB header:ribosome Chain: W: PDB Molecule:60s ribosomal protein l22 (l22e); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome Phyre2 PDB 1rhi chain 1 Region: 25 - 49 Aligned: 25 Modelled: 25 Confidence: 5.8% Identity: 28% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: Positive stranded ssRNA viruses Family: Picornaviridae-like VP (VP1, VP2, VP3 and VP4) Phyre2 1 c5mquA_ 2 c4wm8A_ 3 c2dcoA_ 4 d1cov1_ 5 c1z7s1_ 6 d1bev1_ 7 c3vbfA_ 8 c3iz5w_ 9 d1rhi1_