1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	A	A	V	I	P	R	S	A	R	L	M	V	L	G	G	E	P	R	R	S	N	H	R	V	F	R	P	R	W	L	L	S	A	A	M	T	K	R	A	A	T	A	A	M	V	M	L	L	T	L	T	G	C	G	S	T	H	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																				?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	L	G	P	P	S	G	L	P	D	A	S	P	N	E	R	S	A	I	Q	I	P	A	G	R	I	D	D	A	V	A	K	V	D	G	L	V	G	E	L	M	Q	N	T	G	I	P	G	M	A	V	A	I	V	H	G	G	K	T	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	A	K	G	F	G	V	R	D	V	G	K	G	G	G	P	D	N	K	V	D	A	D	T	V	F	Q	L	A	S	V	S	K	S	V	G	A	T	V	V	A	H	A	V	T	D	N	V	V	T	W	D	T	P	V	V	S	K	L	P
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		W	F	A	L	R	D	P	Y	V	T	G	Q	V	T	I	A	D	L	Y	S	H	R	S	G	L	P	D	H	A	G	D	L	L	E	D	L	G	Y	D	R	R	Q	V	L	Q	R	L	K	Y	L	P	L	A	P	F	R	I	S	Y	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Y	T	N	F	G	V	T	A	A	A	E	A	V	A	A	A	A	G	Q	S	W	E	D	L	S	D	E	V	L	Y	R	P	L	G	M	G	S	T	S	S	R	F	T	D	F	L	A	R	P	N	H	A	V	N	H	V	K	V	A	D
Secondary structure
SS confidence
Disorder																																											?	?		?	?	?	?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	W	E	A	R	Y	Q	R	D	P	D	A	Q	S	P	A	G	G	V	S	S	S	L	N	D	M	T	H	W	L	A	M	V	L	A	D	G	V	Y	N	G	R	R	I	T	S	P	E	A	L	L	P	V	Y	T	P	Q	V	I	S
Secondary structure
SS confidence
Disorder									?	?		?																											?	?	?	?	?	?													?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	H	P	V	S	P	R	A	R	A	S	F	Y	G	Y	G	F	N	V	G	V	T	S	S	G	R	T	E	Y	S	H	S	G	A	F	G	L	G	A	A	A	N	F	V	V	L	P	S	E	D	L	A	I	I	A	L	T	N	A	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	I	G	V	P	E	T	L	T	A	E	F	M	D	L	V	Q	Y	G	Q	V	R	E	D	W	A	A	L	Y	K	K	A	F	A	P	L	N	E	L	A	G	S	L	V	G	K	Q	S	P	A	N	P	A	P	S	R	P	L	N	D
Secondary structure
SS confidence
Disorder		?		?																				?															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		Y	V	G	V	Y	A	N	D	Y	W	G	P	A	T	V	T	Y	H	D	G	Q	L	R	L	S	L	G	P	K	N	Q	T	F	D	L	T	H	W	D	G	D	T	F	T	F	T	L	S	T	E	N	A	L	P	G	S	I	S	K	A
Secondary structure
SS confidence
Disorder																																?																		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.
Sequence		T	F	A	G	D	T	L	N	L	E	Y	Y	D	A	D	K	L	G	T	F	T	R
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 31%) Beta strand ( 20%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 2qmi chain H Region: 90 - 561 Aligned: 422 Modelled: 448 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: H: PDB Molecule:pbp related beta-lactamase; PDBTitle: structure of the octameric penicillin-binding protein2 homologue from pyrococcus abyssi Phyre2 PDB 1ei5 chain A Region: 91 - 562 Aligned: 442 Modelled: 468 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:d-aminopeptidase; PDBTitle: crystal structure of a d-aminopeptidase from ochrobactrum2 anthropi Phyre2 PDB 4ivk chain A Region: 74 - 444 Aligned: 364 Modelled: 371 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:carboxylesterases; PDBTitle: crystal structure of a fammily viii carboxylesterase in a complex with2 cephalothin. Phyre2 PDB 3ozh chain A Region: 91 - 436 Aligned: 333 Modelled: 346 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase/d-alanine carboxypeptidase; PDBTitle: crystal structure of beta-lactamase/d-alanine carboxypeptidase from2 yersinia pestis Phyre2 PDB 4p6b chain B Region: 92 - 427 Aligned: 330 Modelled: 336 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:est-y29; PDBTitle: crystal structure of est-y29,a novel penicillin-binding protein/beta-2 lactamase homolog from a metagenomic library Phyre2 PDB 5gkv chain A Region: 84 - 434 Aligned: 336 Modelled: 351 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:esterase a; PDBTitle: crystal structure of a novel penicillin-binding protein (pbp) homolog2 from caulobacter crescentus Phyre2 PDB 1onh chain A Region: 87 - 436 Aligned: 326 Modelled: 350 Confidence: 100.0% Identity: 21% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1rgy chain A Region: 87 - 436 Aligned: 323 Modelled: 350 Confidence: 100.0% Identity: 20% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 3o3v chain B Region: 92 - 440 Aligned: 333 Modelled: 349 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of clbp peptidase domain Phyre2 PDB 2hds chain A domain 1 Region: 87 - 436 Aligned: 334 Modelled: 350 Confidence: 100.0% Identity: 19% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 4y7p chain A Region: 91 - 436 Aligned: 327 Modelled: 346 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:alkaline d-peptidase; PDBTitle: structure of alkaline d-peptidase from bacillus cereus Phyre2 PDB 4gdn chain B Region: 92 - 436 Aligned: 325 Modelled: 341 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:protein flp; PDBTitle: structure of fmta-like protein Phyre2 PDB 2drw chain A domain 1 Region: 91 - 440 Aligned: 329 Modelled: 350 Confidence: 100.0% Identity: 20% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 2wzz chain A Region: 87 - 436 Aligned: 324 Modelled: 348 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: amp-c beta-lactamase (pseudomonas aeruginosa)in complex2 with compound m-03 Phyre2 PDB 1yqs chain A domain 1 Region: 91 - 441 Aligned: 325 Modelled: 343 Confidence: 100.0% Identity: 20% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 3ws1 chain A Region: 88 - 442 Aligned: 339 Modelled: 352 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: n288q-n321q mutant beta-lactamase derived from chromohalobacter sp.5602 (condition-1b) Phyre2 PDB 5e2h chain B Region: 91 - 436 Aligned: 323 Modelled: 343 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of d-alanine carboxypeptidase ampc from2 mycobacterium smegmatis Phyre2 PDB 2qz6 chain A Region: 91 - 434 Aligned: 321 Modelled: 344 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: first crystal structure of a psychrophile class c beta-2 lactamase Phyre2 PDB 3wwx chain A Region: 91 - 433 Aligned: 317 Modelled: 331 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:s12 family peptidase; PDBTitle: crystal structure of d-stereospecific amidohydrolase from streptomyces2 sp. 82f2 Phyre2 PDB 3tg9 chain A Region: 93 - 422 Aligned: 304 Modelled: 330 Confidence: 100.0% Identity: 19% PDB header:penicillin binding protein Chain: A: PDB Molecule:penicillin-binding protein; PDBTitle: the crystal structure of penicillin binding protein from bacillus2 halodurans Phyre2 1 c2qmiH_ 2 c1ei5A_ 3 c4ivkA_ 4 c3ozhA_ 5 c4p6bB_ 6 c5gkvA_ 7 d1onha_ 8 d1rgya_ 9 c3o3vB_ 10 d2hdsa1 11 c4y7pA_ 12 c4gdnB_ 13 d2drwa1 14 c2wzzA_ 15 d1yqsa1 16 c3ws1A_ 17 c5e2hB_ 18 c2qz6A_ 19 c3wwxA_ 20 c3tg9A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188