1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	K	L	S	G	S	I	D	V	P	L	P	P	E	E	A	W	M	H	A	S	D	L	T	R	Y	R	E	W	L	T	I	H	K	V	W	R	S	K	L	P	E	V	L	E	K	G	T	V	V	E	S	Y	V	E	V	K	G	M
Secondary structure
SS confidence
Disorder		?	?																																					?	?	?	?														?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	N	R	I	K	W	T	I	V	R	Y	K	P	P	E	G	M	T	L	N	G	D	G	V	G	G	V	K	V	K	L	I	A	K	V	A	P	K	E	H	G	S	V	V	S	F	D	V	H	L	G	G	P	A	L	L	G	P	I	G
Secondary structure
SS confidence
Disorder			?																																																	?		?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.
Sequence		M	I	V	A	A	A	L	R	A	D	I	R	E	S	L	Q	N	F	V	T	V	F	A	G
Secondary structure
SS confidence
Disorder																							?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 29%) Beta strand ( 46%)

Rank Aligned region

PDB 2kf2 chain A Region: 1 - 143 Aligned: 143 Modelled: 143 Confidence: 99.9% Identity: 9% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative polyketide cyclase; PDBTitle: solution nmr structure of of streptomyces coelicolor2 polyketide cyclase sco5315. northeast structural genomics3 consortium target rr365 Phyre2 PDB 2rer chain A domain 1 Region: 1 - 143 Aligned: 143 Modelled: 143 Confidence: 99.9% Identity: 13% Fold: TBP-like Superfamily: Bet v1-like Family: oligoketide cyclase/dehydrase-like Phyre2 PDB 2d4r chain A domain 1 Region: 2 - 143 Aligned: 140 Modelled: 142 Confidence: 99.8% Identity: 14% Fold: TBP-like Superfamily: Bet v1-like Family: oligoketide cyclase/dehydrase-like Phyre2 PDB 4xrw chain A Region: 1 - 143 Aligned: 139 Modelled: 143 Confidence: 99.8% Identity: 9% PDB header:lyase Chain: A: PDB Molecule:bexl; PDBTitle: crystal structure of the di-domain aro/cyc bexl from the be-7585a2 biosynthetic pathway Phyre2 PDB 2ns9 chain A domain 1 Region: 1 - 144 Aligned: 141 Modelled: 144 Confidence: 99.8% Identity: 18% Fold: TBP-like Superfamily: Bet v1-like Family: CoxG-like Phyre2 PDB 2m47 chain A Region: 1 - 143 Aligned: 140 Modelled: 143 Confidence: 99.8% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein cgl2373; PDBTitle: solution nmr structure of the polyketide_cyc-like protein cgl2372 from2 corynebacterium glutamicum, northeast structural genomics consortium3 target cgr160 Phyre2 PDB 1t17 chain A Region: 1 - 144 Aligned: 144 Modelled: 144 Confidence: 99.8% Identity: 13% Fold: TBP-like Superfamily: Bet v1-like Family: oligoketide cyclase/dehydrase-like Phyre2 PDB 3tfz chain B Region: 1 - 143 Aligned: 141 Modelled: 143 Confidence: 99.8% Identity: 12% PDB header:biosynthetic protein Chain: B: PDB Molecule:cyclase; PDBTitle: crystal structure of zhui aromatase/cyclase from streptomcyes sp.2 r1128 Phyre2 PDB 5z8o chain A Region: 4 - 143 Aligned: 139 Modelled: 140 Confidence: 99.8% Identity: 14% PDB header:unknown function Chain: A: PDB Molecule:cyclase/dehydrase; PDBTitle: structural of start superfamily protein msmeg_0129 from mycobacterium2 smegmatis Phyre2 PDB 2le1 chain A Region: 1 - 143 Aligned: 141 Modelled: 143 Confidence: 99.8% Identity: 11% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of tfu_2981 from thermobifida fusca, northeast2 structural genomics consortium target tfr85a Phyre2 PDB 2b79 chain A domain 1 Region: 3 - 143 Aligned: 135 Modelled: 141 Confidence: 99.8% Identity: 13% Fold: TBP-like Superfamily: Bet v1-like Family: Smu440-like Phyre2 PDB 5wox chain A Region: 1 - 144 Aligned: 141 Modelled: 144 Confidence: 99.8% Identity: 16% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: nmr solution structure of kany protein (ms6282) using two 4d-spectra Phyre2 PDB 2pcs chain A domain 1 Region: 3 - 143 Aligned: 139 Modelled: 141 Confidence: 99.7% Identity: 16% Fold: TBP-like Superfamily: Bet v1-like Family: CoxG-like Phyre2 PDB 3p9v chain A Region: 3 - 142 Aligned: 139 Modelled: 136 Confidence: 99.7% Identity: 10% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: high resolution crystal structure of protein maqu_3174 from2 marinobacter aquaeolei, northeast structural genomics consortium3 target mqr197 Phyre2 PDB 4xrt chain B Region: 4 - 143 Aligned: 129 Modelled: 140 Confidence: 99.7% Identity: 10% PDB header:lyase Chain: B: PDB Molecule:stfq aromatase/cyclase; PDBTitle: crystal structure of the di-domain aro/cyc stfq from the steffimycin2 biosynthetic pathway Phyre2 PDB 2l9p chain A Region: 3 - 144 Aligned: 139 Modelled: 139 Confidence: 99.7% Identity: 6% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of q5hli9 from staphylococcus epidermidis,2 northeast structural genomics consortium target ser147 Phyre2 PDB 2lf2 chain A Region: 3 - 144 Aligned: 139 Modelled: 142 Confidence: 99.6% Identity: 9% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the ahsa1-like protein chu_1110 from2 cytophaga hutchinsonii, northeast structural genomics consortium3 target chr152 Phyre2 PDB 3pu2 chain G Region: 3 - 143 Aligned: 136 Modelled: 137 Confidence: 99.6% Identity: 16% PDB header:structure genomics, unknown function Chain: G: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the q3j4m4_rhos4 protein from rhodobacter2 sphaeroides. northeast structural genomics consortium target rhr263. Phyre2 PDB 3cnw chain A domain 1 Region: 2 - 143 Aligned: 134 Modelled: 142 Confidence: 99.6% Identity: 10% Fold: TBP-like Superfamily: Bet v1-like Family: Atu1531-like Phyre2 PDB 2ldk chain A Region: 3 - 143 Aligned: 138 Modelled: 141 Confidence: 99.6% Identity: 12% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of protein aaur_3427 from arthrobacter2 aurescens, northeast structural genomics consortium target aar96 Phyre2 1 c2kf2A_ 2 d2rera1 3 d2d4ra1 4 c4xrwA_ 5 d2ns9a1 6 c2m47A_ 7 d1t17a_ 8 c3tfzB_ 9 c5z8oA_ 10 c2le1A_ 11 d2b79a1 12 c5woxA_ 13 d2pcsa1 14 c3p9vA_ 15 c4xrtB_ 16 c2l9pA_ 17 c2lf2A_ 18 c3pu2G_ 19 d3cnwa1 20 c2ldkA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103