1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	I	T	I	V	G	K	Y	L	S	T	L	P	E	D	D	D	H	P	Y	R	T	G	P	W	R	P	Q	T	T	E	W	D	A	D	D	L	T	T	V	T	G	E	V	P	A	D	L	D	G	I	Y	L	R	N	T	E	N	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?																																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	H	P	A	F	A	T	Y	H	P	F	D	G	D	G	M	I	H	V	V	G	F	R	D	G	K	A	F	Y	R	N	R	F	I	R	T	D	G	F	L	A	E	N	E	A	G	G	P	L	W	P	G	L	A	E	P	V	Q	L	A
Secondary structure
SS confidence
Disorder		?	?	?		?	?																																							?	?										?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	R	E	H	G	W	G	A	R	G	L	M	K	D	A	S	S	T	D	V	I	V	H	R	G	I	A	L	T	S	F	Y	Q	C	G	D	L	Y	R	I	D	P	Y	S	A	N	T	L	G	K	E	S	W	H	G	R	F	P	F	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?																																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		W	G	V	S	A	H	P	K	V	D	N	K	T	G	E	L	L	F	F	N	Y	S	K	Q	E	P	Y	M	R	Y	G	V	V	D	Q	N	N	E	L	V	H	Y	V	D	V	P	L	P	G	P	R	L	P	H	D	M	A	F	T	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	Y	V	I	L	N	D	F	P	L	F	W	D	P	R	L	L	E	R	D	V	H	L	P	R	F	Y	P	E	I	P	S	R	F	A	V	V	A	R	R	G	N	D	I	R	W	F	E	A	D	P	T	F	V	L	H	F	T	N	A
Secondary structure
SS confidence
Disorder													?						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	E	Q	G	D	E	I	V	L	D	G	F	Y	E	G	D	P	Q	P	L	D	T	G	G	T	K	W	E	K	L	F	R	F	L	A	L	D	R	L	Q	S	R	L	H	R	W	R	L	N	M	V	T	G	A	V	H	E	E	Q	L
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	E	S	I	T	E	F	G	T	I	N	A	D	Y	A	A	S	S	Y	R	Y	T	Y	A	A	T	G	K	P	S	W	F	L	F	D	G	L	V	K	H	D	L	L	T	G	N	H	E	C	Y	S	F	G	D	G	V	Y	G	S	E
Secondary structure
SS confidence
Disorder																													?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		T	A	M	A	P	R	V	G	S	S	A	E	D	D	G	Y	L	V	T	L	T	T	D	M	N	D	D	A	S	Y	C	L	V	F	D	A	A	R	P	G	D	G	P	I	C	K	L	A	L	P	E	R	I	S	S	G	T	H	S	A
Secondary structure
SS confidence
Disorder								?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.
Sequence		W	V	P	G	A	E	L	R	R	W	D	H	A	E	S	P	A	A	A	V	G	L
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 5%) Beta strand ( 42%)

Rank Aligned region

PDB 5j54 chain A Region: 15 - 487 Aligned: 461 Modelled: 473 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:carotenoid oxygenase; PDBTitle: the structure and mechanism of nov1, a resveratrol-cleaving2 dioxygenase Phyre2 PDB 5v2d chain A Region: 12 - 484 Aligned: 460 Modelled: 468 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:dioxygenase; PDBTitle: crystal structure of pseudomonas brassicacearum lignostilbene2 dioxygenase Phyre2 PDB 5u90 chain A Region: 10 - 489 Aligned: 466 Modelled: 480 Confidence: 100.0% Identity: 26% PDB header:oxidoreductase Chain: A: PDB Molecule:carotenoid oxygenase 1; PDBTitle: crystal structure of co-cao1 in complex with resveratrol Phyre2 PDB 3npe chain A Region: 4 - 492 Aligned: 470 Modelled: 477 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:9-cis-epoxycarotenoid dioxygenase 1, chloroplastic; PDBTitle: structure of vp14 in complex with oxygen Phyre2 PDB 2biw chain C Region: 14 - 484 Aligned: 463 Modelled: 466 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: C: PDB Molecule:apocarotenoid-cleaving oxygenase; PDBTitle: crystal structure of apocarotenoid cleavage oxygenase from2 synechocystis, native enzyme Phyre2 PDB 3fsn chain A Region: 18 - 484 Aligned: 446 Modelled: 467 Confidence: 100.0% Identity: 18% PDB header:isomerase Chain: A: PDB Molecule:retinal pigment epithelium-specific 65 kda protein; PDBTitle: crystal structure of rpe65 at 2.14 angstrom resolution Phyre2 PDB 6rte chain B Region: 145 - 476 Aligned: 294 Modelled: 316 Confidence: 83.4% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:cytochrome c; PDBTitle: dihydro-heme d1 dehydrogenase nirn in complex with dhe Phyre2 PDB 4cvc chain A Region: 72 - 473 Aligned: 357 Modelled: 374 Confidence: 77.4% Identity: 10% PDB header:oxidoreductase Chain: A: PDB Molecule:alcohol dehydrogenase; PDBTitle: crystal structure of quinone-dependent alcohol dehydrogenase from2 pseudogluconobacter saccharoketogenenes with zinc in the active site Phyre2 PDB 1nno chain A Region: 145 - 470 Aligned: 267 Modelled: 290 Confidence: 57.4% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:nitrite reductase; PDBTitle: conformational changes occurring upon no binding in nitrite reductase2 from pseudomonas aeruginosa Phyre2 PDB 1mda chain H Region: 159 - 234 Aligned: 71 Modelled: 76 Confidence: 39.4% Identity: 11% Fold: 7-bladed beta-propeller Superfamily: YVTN repeat-like/Quinoprotein amine dehydrogenase Family: Methylamine dehydrogenase, H-chain Phyre2 PDB 5dil chain A Region: 294 - 321 Aligned: 28 Modelled: 28 Confidence: 31.2% Identity: 32% PDB header:rna-binding protein, viral protein Chain: A: PDB Molecule:non-structural protein 1; PDBTitle: crystal structure of the effector domain of the ns1 protein from2 influenza virus b Phyre2 PDB 2hu7 chain A domain 1 Region: 437 - 477 Aligned: 34 Modelled: 41 Confidence: 26.9% Identity: 15% Fold: 7-bladed beta-propeller Superfamily: Peptidase/esterase 'gauge' domain Family: Acylamino-acid-releasing enzyme, N-terminal donain Phyre2 PDB 3qc2 chain A Region: 433 - 474 Aligned: 39 Modelled: 42 Confidence: 26.4% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:glycosyl hydrolase; PDBTitle: crystal structure of a glycosyl hydrolase (bacova_03624) from2 bacteroides ovatus at 2.30 a resolution Phyre2 PDB 5ayc chain A Region: 433 - 474 Aligned: 39 Modelled: 42 Confidence: 25.2% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:4-o-beta-d-mannosyl-d-glucose phosphorylase; PDBTitle: crystal structure of ruminococcus albus 4-o-beta-d-mannosyl-d-glucose2 phosphorylase (ramp1) in complexes with sulfate and 4-o-beta-d-3 mannosyl-d-glucose Phyre2 PDB 5f30 chain B Region: 380 - 470 Aligned: 80 Modelled: 91 Confidence: 21.4% Identity: 18% PDB header:oxidoreductase Chain: B: PDB Molecule:thiocyanate dehydrogenase; PDBTitle: thiocyanate dehydrogenase from thioalkalivibrio paradoxus Phyre2 PDB 1zak chain A domain 2 Region: 188 - 206 Aligned: 19 Modelled: 19 Confidence: 21.4% Identity: 32% Fold: Rubredoxin-like Superfamily: Microbial and mitochondrial ADK, insert "zinc finger" domain Family: Microbial and mitochondrial ADK, insert "zinc finger" domain Phyre2 PDB 5c2w chain D Region: 341 - 440 Aligned: 90 Modelled: 100 Confidence: 21.2% Identity: 13% PDB header:oxidoreductase Chain: D: PDB Molecule:hydrazine synthase alpha subunit; PDBTitle: kuenenia stuttgartiensis hydrazine synthase pressurized with 20 bar2 xenon Phyre2 PDB 3wat chain A Region: 433 - 474 Aligned: 41 Modelled: 42 Confidence: 17.2% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:4-o-beta-d-mannosyl-d-glucose phosphorylase; PDBTitle: crystal structure of 4-o-beta-d-mannosyl-d-glucose phosphorylase mgp2 complexed with man+glc Phyre2 PDB 3met chain B Region: 424 - 475 Aligned: 51 Modelled: 52 Confidence: 15.8% Identity: 18% PDB header:transcription Chain: B: PDB Molecule:saga-associated factor 29 homolog; PDBTitle: crystal structure of sgf29 in complex with h3k4me2 Phyre2 PDB 3elq chain A Region: 194 - 287 Aligned: 87 Modelled: 94 Confidence: 14.5% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:arylsulfate sulfotransferase; PDBTitle: crystal structure of a bacterial arylsulfate2 sulfotransferase Phyre2 1 c5j54A_ 2 c5v2dA_ 3 c5u90A_ 4 c3npeA_ 5 c2biwC_ 6 c3fsnA_ 7 c6rteB_ 8 c4cvcA_ 9 c1nnoA_ 10 d1mdah_ 11 c5dilA_ 12 d2hu7a1 13 c3qc2A_ 14 c5aycA_ 15 c5f30B_ 16 d1zaka2 17 c5c2wD_ 18 c3watA_ 19 c3metB_ 20 c3elqA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77