1

.

.

.

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.

.

.

10

.

.

.

.

.

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20

.

.

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30

.

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40

.

.

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.

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.

.

50

.

.

.

.

.

.

.

.

.

60

Sequence

M

D

F

G

L

L

P

P

E

V

N

S

S

R

M

Y

S

G

P

G

P

E

S

M

L

A

A

A

A

A

W

D

G

V

A

A

E

L

T

S

A

A

V

S

Y

G

S

V

V

S

T

L

I

V

E

P

W

M

G

P

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

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.

.

.

.

80

.

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90

.

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100

.

.

.

.

.

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.

.

.

110

.

.

.

.

.

.

.

.

.

120

Sequence

A

A

A

A

M

A

A

A

A

T

P

Y

V

G

W

L

A

A

T

A

A

L

A

K

E

T

A

T

Q

A

R

A

A

A

E

A

F

G

T

A

F

A

M

T

V

P

P

S

L

V

A

A

N

R

S

R

L

M

S

L

Secondary structure

SS confidence

Disorder

Disorder confidence

.

.

.

.

.

.

.

.

.

130

.

.

.

.

.

.

.

.

.

140

.

.

.

.

.

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.

.

150

.

.

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.

.

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160

.

.

.

.

.

.

.

.

.

170

.

.

.

.

.

.

.

.

.

180

Sequence

V

A

A

N

I

L

G

Q

N

S

A

A

I

A

A

T

Q

A

E

Y

A

E

M

W

A

Q

D

A

A

V

M

Y

S

Y

E

G

A

S

A

A

A

S

A

L

P

P

F

T

P

P

V

Q

G

T

G

P

A

G

P

A

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

190

.

.

.

.

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.

.

.

.

200

.

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.

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210

.

.

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.

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220

.

.

.

.

.

.

.

.

.

230

.

.

.

.

.

.

.

.

.

240

Sequence

A

A

A

A

A

T

Q

A

A

G

A

G

A

V

A

D

A

Q

A

T

L

A

Q

L

P

P

G

I

L

S

D

I

L

S

A

L

A

A

N

A

D

P

L

T

S

G

L

L

G

I

A

S

T

L

N

P

Q

V

G

S

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

250

.

.

.

.

.

.

.

.

.

260

.

.

.

.

.

.

.

.

.

270

.

.

.

.

.

.

.

.

.

280

.

.

.

.

.

.

.

.

.

290

.

.

.

.

.

.

.

.

.

300

Sequence

A

Q

P

I

V

I

P

T

P

I

G

E

L

D

V

I

A

L

Y

I

A

S

I

A

T

G

S

I

A

L

A

I

T

N

T

A

R

P

W

H

I

G

L

Y

G

N

A

G

G

L

G

P

T

Q

G

H

P

L

S

S

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

310

.

.

.

.

.

.

.

.

.

320

.

.

.

.

.

.

.

.

.

330

.

.

.

.

.

.

.

.

.

340

.

.

.

.

.

.

.

.

.

350

.

.

.

.

.

.

.

.

.

360

Sequence

A

T

D

E

P

E

P

H

W

G

P

F

G

G

A

A

P

V

S

A

G

V

G

H

A

A

L

V

G

A

L

S

V

P

H

S

W

T

T

A

A

P

E

I

Q

L

A

V

Q

A

T

P

T

F

S

S

S

A

G

A

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

370

.

.

.

.

.

.

.

.

.

380

.

.

.

.

.

.

.

.

.

390

.

.

.

.

.

.

.

.

.

400

.

.

.

.

.

.

.

.

.

410

.

.

.

.

.

.

.

.

.

420

Sequence

D

P

T

A

L

N

G

M

P

A

G

L

L

S

G

M

A

L

A

S

L

A

A

R

G

T

T

G

G

G

G

T

R

S

G

T

S

T

D

G

Q

E

D

G

R

K

P

P

V

V

V

I

R

E

Q

P

P

P

G

N

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

Sequence

P

P

R

Secondary structure

SS confidence

Disorder

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 60%) Alpha helix ( 55%) Beta strand ( 1%)

Rank Aligned region

PDB 5xfs chain B Region: 1 - 173 Aligned: 173 Modelled: 173 Confidence: 100.0% Identity: 58% PDB header:protein transport Chain: B: PDB Molecule:ppe family protein ppe15; PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis Phyre2 PDB 2g38 chain B Region: 2 - 173 Aligned: 171 Modelled: 172 Confidence: 100.0% Identity: 36% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:ppe family protein; PDBTitle: a pe/ppe protein complex from mycobacterium tuberculosis Phyre2 PDB 2g38 chain B domain 1 Region: 2 - 173 Aligned: 171 Modelled: 172 Confidence: 100.0% Identity: 36% Fold: Ferritin-like Superfamily: PE/PPE dimer-like Family: PPE Phyre2 PDB 4xy3 chain A Region: 4 - 173 Aligned: 154 Modelled: 170 Confidence: 100.0% Identity: 19% PDB header:protein transport Chain: A: PDB Molecule:esx-1 secretion-associated protein espb; PDBTitle: structure of esx-1 secreted protein espb Phyre2 PDB 4wj2 chain A Region: 14 - 172 Aligned: 138 Modelled: 155 Confidence: 98.5% Identity: 23% PDB header:unknown function Chain: A: PDB Molecule:antigen mtb48; PDBTitle: mycobacterial protein Phyre2 PDB 2vs0 chain B Region: 21 - 100 Aligned: 79 Modelled: 80 Confidence: 97.9% Identity: 15% PDB header:cell invasion Chain: B: PDB Molecule:virulence factor esxa; PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa Phyre2 PDB 4iog chain D Region: 21 - 99 Aligned: 78 Modelled: 79 Confidence: 97.7% Identity: 17% PDB header:unknown function Chain: D: PDB Molecule:secreted protein esxb; PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne Phyre2 PDB 3gvm chain A Region: 21 - 100 Aligned: 79 Modelled: 80 Confidence: 97.7% Identity: 14% PDB header:viral protein Chain: A: PDB Molecule:putative uncharacterized protein sag1039; PDBTitle: structure of the homodimeric wxg-100 family protein from streptococcus2 agalactiae Phyre2 PDB 3zbh chain C Region: 21 - 100 Aligned: 79 Modelled: 80 Confidence: 97.6% Identity: 18% PDB header:unknown function Chain: C: PDB Molecule:esxa; PDBTitle: geobacillus thermodenitrificans esxa crystal form i Phyre2 PDB 1wa8 chain A domain 1 Region: 21 - 100 Aligned: 79 Modelled: 80 Confidence: 97.1% Identity: 19% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 4lws chain B Region: 21 - 98 Aligned: 77 Modelled: 78 Confidence: 95.9% Identity: 13% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 1wa8 chain B domain 1 Region: 22 - 100 Aligned: 78 Modelled: 79 Confidence: 95.6% Identity: 17% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 4lws chain A Region: 21 - 100 Aligned: 79 Modelled: 77 Confidence: 95.5% Identity: 13% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 4i0x chain A Region: 23 - 97 Aligned: 74 Modelled: 75 Confidence: 92.8% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:esat-6-like protein mab_3112; PDBTitle: crystal structure of the mycobacterum abscessus esxef (mab_3112-2 mab_3113) complex Phyre2 PDB 2kg7 chain B Region: 31 - 100 Aligned: 69 Modelled: 70 Confidence: 90.1% Identity: 14% PDB header:unknown function Chain: B: PDB Molecule:esat-6-like protein esxh; PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288 Phyre2 PDB 4i0x chain J Region: 32 - 97 Aligned: 61 Modelled: 66 Confidence: 58.9% Identity: 28% PDB header:structural genomics, unknown function Chain: J: PDB Molecule:esat-6-like protein mab_3113; PDBTitle: crystal structure of the mycobacterum abscessus esxef (mab_3112-2 mab_3113) complex Phyre2 PDB 1ui5 chain A domain 2 Region: 71 - 144 Aligned: 54 Modelled: 72 Confidence: 39.0% Identity: 19% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 5frg chain A Region: 2 - 9 Aligned: 8 Modelled: 8 Confidence: 16.1% Identity: 75% PDB header:protein binding Chain: A: PDB Molecule:formin-binding protein 1-like; PDBTitle: the nmr structure of the cdc42-interacting region of toca1 Phyre2 PDB 1bkv chain A Region: 8 - 23 Aligned: 16 Modelled: 16 Confidence: 13.7% Identity: 38% PDB header:structural protein Chain: A: PDB Molecule:t3-785; PDBTitle: collagen Phyre2 PDB 4xb6 chain D Region: 137 - 145 Aligned: 9 Modelled: 9 Confidence: 13.4% Identity: 33% PDB header:transferase Chain: D: PDB Molecule:alpha-d-ribose 1-methylphosphonate 5-phosphate c-p lyase; PDBTitle: structure of the e. coli c-p lyase core complex Phyre2 1 c5xfsB_ 2 c2g38B_ 3 d2g38b1 4 c4xy3A_ 5 c4wj2A_ 6 c2vs0B_ 7 c4iogD_ 8 c3gvmA_ 9 c3zbhC_ 10 d1wa8a1 11 c4lwsB_ 12 d1wa8b1 13 c4lwsA_ 14 c4i0xA_ 15 c2kg7B_ 16 c4i0xJ_ 17 d1ui5a2 18 c5frgA_ 19 c1bkvA_ 20 c4xb6D_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60