1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	K	E	R	G	D	Q	N	A	V	V	D	A	L	R	S	I	Q	P	A	V	F	I	P	A	S	V	V	I	V	A	M	I	V	V	S	V	V	Y	S	S	V	A	E	N	A	F	V	R	L	N	S	A	I	T	G	G	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	W	W	Y	I	L	V	A	T	G	F	V	V	F	A	L	Y	C	G	I	S	R	I	G	T	I	R	L	G	R	D	D	E	L	P	E	F	S	F	W	A	W	L	A	M	L	F	S	A	G	M	G	I	G	L	V	F	Y	G	V
Secondary structure
SS confidence
Disorder																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	E	P	L	S	H	Y	L	R	P	P	R	S	R	G	V	P	A	L	T	D	A	A	A	N	Q	A	M	A	L	T	V	F	H	W	G	L	H	A	W	A	I	Y	V	V	V	G	L	G	M	A	Y	M	T	Y	R	R	G	R	P
Secondary structure
SS confidence
Disorder													?		?	?	?	?	?																																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	S	V	R	W	L	L	E	P	V	V	G	R	G	R	V	E	G	A	L	G	H	A	V	D	V	I	A	I	V	G	T	L	F	G	V	A	T	S	L	G	F	G	I	T	Q	I	A	S	G	L	E	Y	L	G	W	I	R	V	D
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	W	W	M	V	G	M	I	A	A	I	T	A	T	A	T	A	S	V	V	S	G	V	S	K	G	L	K	W	L	S	N	I	N	M	A	L	A	A	A	L	A	L	F	V	L	L	L	G	P	T	L	F	L	L	Q	S	W	V	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		N	L	G	G	Y	V	Q	S	L	P	Q	F	M	L	R	T	A	P	F	S	H	D	G	W	L	G	D	W	T	I	F	Y	W	G	W	W	I	S	W	A	P	F	V	G	M	F	I	A	R	I	S	R	G	R	T	I	R	E	F	I
Secondary structure
SS confidence
Disorder																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	A	V	L	L	V	P	T	V	I	A	S	L	W	F	T	I	F	G	D	S	A	L	L	R	Q	R	N	N	G	D	M	L	V	N	G	A	V	D	T	N	T	S	L	F	R	L	L	D	G	L	P	I	G	A	I	T	S	V	L
Secondary structure
SS confidence
Disorder																													?		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	V	L	V	I	V	F	F	F	V	T	S	S	D	S	G	S	L	V	I	D	I	L	S	A	G	G	E	L	D	P	P	K	L	T	R	V	Y	W	A	V	L	E	G	V	A	A	A	V	L	L	L	I	G	G	A	G	S	L	T
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	L	R	T	A	A	I	A	T	A	L	P	F	S	I	V	M	V	V	A	C	Y	A	M	T	K	A	F	H	F	D	L	A	A	T	P	R	L	L	H	V	T	V	P	D	V	V	A	A	G	N	R	R	R	H	D	I	S	A	T
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.
Sequence		L	S	G	L	I	A	V	R	D	V	D	S	G	T	Y	I	V	H	P	D	T	G	A	L	T	V	T	A	P	P	D	P	L	D	D	H	V	F	E	S	D	R	H	V	T	R	R	N	T	T	S	S	R
Secondary structure
SS confidence
Disorder		?		?	?		?	?	?				?	?	?	?	?		?																?	?		?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 77%) Beta strand ( 0%) TM helix ( 48%) (View membrane topology prediction)

Rank Aligned region

PDB 2w8a chain C Region: 18 - 531 Aligned: 506 Modelled: 514 Confidence: 100.0% Identity: 41% PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate Phyre2 PDB 3hfx chain A Region: 21 - 511 Aligned: 484 Modelled: 484 Confidence: 100.0% Identity: 26% PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter Phyre2 PDB 4ain chain B Region: 18 - 521 Aligned: 492 Modelled: 494 Confidence: 100.0% Identity: 41% PDB header:membrane protein Chain: B: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of betp with asymmetric protomers. Phyre2 PDB 5nva chain A Region: 59 - 502 Aligned: 401 Modelled: 401 Confidence: 99.3% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:putative sodium:solute symporter; PDBTitle: substrate-bound outward-open state of a na+-coupled sialic acid2 symporter reveals a novel na+-site Phyre2 PDB 2xq2 chain A Region: 61 - 502 Aligned: 390 Modelled: 390 Confidence: 97.9% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 5i6x chain A Region: 248 - 514 Aligned: 257 Modelled: 267 Confidence: 97.6% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:sodium-dependent serotonin transporter; PDBTitle: x-ray structure of the ts3 human serotonin transporter complexed with2 paroxetine at the central site Phyre2 PDB 4m48 chain A Region: 248 - 510 Aligned: 257 Modelled: 263 Confidence: 97.6% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:transporter; PDBTitle: x-ray structure of dopamine transporter elucidates antidepressant2 mechanism Phyre2 PDB 2a65 chain A domain 1 Region: 150 - 514 Aligned: 353 Modelled: 365 Confidence: 97.4% Identity: 13% Fold: SNF-like Superfamily: SNF-like Family: SNF-like Phyre2 PDB 4us3 chain A Region: 157 - 517 Aligned: 342 Modelled: 361 Confidence: 97.2% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:transporter; PDBTitle: crystal structure of the bacterial nss member mhst in an2 occluded inward-facing state Phyre2 PDB 5oqt chain A Region: 90 - 516 Aligned: 373 Modelled: 373 Confidence: 97.2% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:amino acid transporter; PDBTitle: crystal structure of a bacterial cationic amino acid transporter (cat)2 homologue Phyre2 PDB 3dh4 chain A Region: 147 - 502 Aligned: 343 Modelled: 356 Confidence: 97.1% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 2jln chain A Region: 153 - 519 Aligned: 337 Modelled: 337 Confidence: 96.9% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 3gia chain A Region: 93 - 518 Aligned: 368 Modelled: 368 Confidence: 96.2% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter Phyre2 PDB 4dji chain A Region: 155 - 516 Aligned: 341 Modelled: 350 Confidence: 95.9% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 6irt chain B Region: 155 - 516 Aligned: 334 Modelled: 362 Confidence: 95.5% Identity: 12% PDB header:membrane protein Chain: B: PDB Molecule:large neutral amino acids transporter small subunit 1; PDBTitle: human lat1-4f2hc complex bound with bch Phyre2 PDB 6f2w chain A Region: 96 - 518 Aligned: 366 Modelled: 366 Confidence: 92.6% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:putative amino acid/polyamine transport protein; PDBTitle: bacterial asc transporter crystal structure in open to in conformation Phyre2 PDB 3lrc chain C Region: 155 - 519 Aligned: 315 Modelled: 315 Confidence: 91.9% Identity: 12% PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) Phyre2 PDB 4wgv chain C Region: 196 - 510 Aligned: 281 Modelled: 291 Confidence: 68.2% Identity: 12% PDB header:transport protein Chain: C: PDB Molecule:divalent metal cation transporter mnth; PDBTitle: crystal structure of staphylococcus capitis divalent metal ion2 transporter (dmt) in complex with nanobody Phyre2 PDB 4wgw chain A Region: 196 - 510 Aligned: 281 Modelled: 291 Confidence: 68.2% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:divalent metal cation transporter mnth; PDBTitle: staphylococcus capitis divalent metal ion transporter (dmt) in complex2 with manganese Phyre2 PDB 6bm8 chain A Region: 8 - 80 Aligned: 66 Modelled: 73 Confidence: 40.7% Identity: 14% PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein b; PDBTitle: crystal structure of glycoprotein b from herpes simplex virus type i Phyre2 1 c2w8aC_ 2 c3hfxA_ 3 c4ainB_ 4 c5nvaA_ 5 c2xq2A_ 6 c5i6xA_ 7 c4m48A_ 8 d2a65a1 9 c4us3A_ 10 c5oqtA_ 11 c3dh4A_ 12 c2jlnA_ 13 c3giaA_ 14 c4djiA_ 15 c6irtB_ 16 c6f2wA_ 17 c3lrcC_ 18 c4wgvC_ 19 c4wgwA_ 20 c6bm8A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73