1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	A	R	A	G	E	V	G	R	A	G	P	A	I	R	W	L	G	G	I	G	A	V	I	P	L	L	A	L	V	L	V	L	V	V	L	V	I	E	A	M	G	A	I	R	L	N	G	L	H	F	F	T	A	T	E	W	N	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																																																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	N	T	Y	G	E	T	V	V	T	D	G	V	A	H	P	V	G	A	Y	Y	G	A	L	P	L	I	V	G	T	L	A	T	S	A	I	A	L	I	I	A	V	P	V	S	V	G	A	A	L	V	I	V	E	R	L	P	K	R	L
Secondary structure
SS confidence
Disorder		?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	E	A	V	G	I	V	L	E	L	L	A	G	I	P	S	V	V	V	G	L	W	G	A	M	T	F	G	P	F	I	A	H	H	I	A	P	V	I	A	H	N	A	P	D	V	P	V	L	N	Y	L	R	G	D	P	G	N	G	E
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?	?	?				?		?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	M	L	V	S	G	L	V	L	A	V	M	V	V	P	I	I	A	T	T	T	H	D	L	F	R	Q	V	P	V	L	P	R	E	G	A	I	A	L	G	M	S	N	W	E	C	V	R	R	V	T	L	P	W	V	S	S	G	I	V
Secondary structure
SS confidence
Disorder																												?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	A	V	V	L	G	L	G	R	A	L	G	E	T	M	A	V	A	M	V	S	G	A	V	L	G	A	M	P	A	N	I	Y	A	T	M	T	T	I	A	A	T	I	V	S	Q	L	D	S	A	M	T	D	S	T	N	F	A	V	K
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?	?	?	?	?	?	?	?												?		?	?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.
Sequence		T	L	A	E	V	G	L	V	L	M	V	I	T	L	L	T	N	V	A	A	R	G	M	V	R	R	V	S	R	T	A	L	P	V	G	R	G	I
Secondary structure
SS confidence
Disorder																														?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 76%) Beta strand ( 0%) TM helix ( 46%) (View membrane topology prediction)

Rank Aligned region

PDB 4tqv chain I Region: 7 - 329 Aligned: 285 Modelled: 303 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: I: PDB Molecule:algm1; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 3fh6 chain F Region: 23 - 329 Aligned: 298 Modelled: 307 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 2r6g chain F Region: 55 - 319 Aligned: 256 Modelled: 265 Confidence: 100.0% Identity: 12% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 2r6g chain F domain 2 Region: 71 - 319 Aligned: 240 Modelled: 249 Confidence: 100.0% Identity: 13% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain G domain 1 Region: 10 - 334 Aligned: 277 Modelled: 290 Confidence: 100.0% Identity: 14% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 4tqv chain J Region: 12 - 327 Aligned: 279 Modelled: 286 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: J: PDB Molecule:algm2; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 2onk chain C Region: 24 - 323 Aligned: 247 Modelled: 251 Confidence: 100.0% Identity: 19% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 2onk chain C domain 1 Region: 24 - 323 Aligned: 247 Modelled: 251 Confidence: 100.0% Identity: 19% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3d31 chain C domain 1 Region: 25 - 321 Aligned: 247 Modelled: 248 Confidence: 100.0% Identity: 15% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3d31 chain D Region: 25 - 321 Aligned: 247 Modelled: 248 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease protein; PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 4ymu chain C Region: 70 - 328 Aligned: 214 Modelled: 214 Confidence: 100.0% Identity: 21% PDB header:protein binding/transport protein Chain: C: PDB Molecule:abc-type amino acid transport system, permease component; PDBTitle: crystal structure of an amino acid abc transporter complex with2 arginines and atps Phyre2 PDB 3dhw chain A domain 1 Region: 83 - 319 Aligned: 192 Modelled: 192 Confidence: 99.9% Identity: 18% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 5kbu chain A Region: 89 - 328 Aligned: 178 Modelled: 182 Confidence: 81.6% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:glutamate receptor 2,voltage-dependent calcium channel PDBTitle: cryo-em structure of glua2-2xstz complex at 7.8 angstrom resolution Phyre2 PDB 2m8g chain X Region: 200 - 230 Aligned: 31 Modelled: 31 Confidence: 21.6% Identity: 13% PDB header:transcription Chain: X: PDB Molecule:transcriptional regulator; PDBTitle: structure, function, and tethering of dna-binding domains in 542 transcriptional activators Phyre2 PDB 2n2a chain A Region: 88 - 128 Aligned: 41 Modelled: 41 Confidence: 20.2% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: spatial structure of her2/erbb2 dimeric transmembrane domain in the2 presence of cytoplasmic juxtamembrane domains Phyre2 PDB 4qiw chain T Region: 213 - 226 Aligned: 14 Modelled: 14 Confidence: 12.9% Identity: 21% PDB header:transcription Chain: T: PDB Molecule:dna-directed rna polymerase subunit k; PDBTitle: crystal structure of euryarchaeal rna polymerase from thermococcus2 kodakarensis Phyre2 PDB 4l5e chain A Region: 200 - 230 Aligned: 31 Modelled: 31 Confidence: 12.6% Identity: 13% PDB header:protein binding Chain: A: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of a. aeolicus ntrc1 dna binding domain Phyre2 PDB 1twc chain F Region: 213 - 226 Aligned: 14 Modelled: 14 Confidence: 11.8% Identity: 29% PDB header:transcription Chain: F: PDB Molecule:dna-directed rna polymerases i, ii, and iii 23 PDBTitle: rna polymerase ii complexed with gtp Phyre2 PDB 1twf chain F Region: 213 - 226 Aligned: 14 Modelled: 14 Confidence: 11.8% Identity: 29% Fold: RPB6/omega subunit-like Superfamily: RPB6/omega subunit-like Family: RPB6 Phyre2 PDB 2pmz chain W Region: 213 - 226 Aligned: 14 Modelled: 14 Confidence: 11.5% Identity: 14% PDB header:translation, transferase Chain: W: PDB Molecule:dna-directed rna polymerase subunit k; PDBTitle: archaeal rna polymerase from sulfolobus solfataricus Phyre2 1 c4tqvI_ 2 c3fh6F_ 3 c2r6gF_ 4 d2r6gf2 5 d2r6gg1 6 c4tqvJ_ 7 c2onkC_ 8 d2onkc1 9 d3d31c1 10 c3d31D_ 11 c4ymuC_ 12 d3dhwa1 13 c5kbuA_ 14 c2m8gX_ 15 c2n2aA_ 16 c4qiwT_ 17 c4l5eA_ 18 c1twcF_ 19 d1twff_ 20 c2pmzW_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40