1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	R	V	S	A	S	A	D	D	R	A	A	G	A	R	P	A	R	D	L	V	R	V	A	F	G	P	G	V	V	A	L	G	I	I	A	A	V	T	L	L	Q	L	L	I	A	N	S	D	M	T	G	A	W	G	A	I	A	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																												?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	W	L	G	V	H	L	V	P	I	S	I	G	G	R	A	L	G	V	M	P	L	L	P	V	L	L	M	V	W	A	T	A	R	S	T	A	R	A	T	S	P	Q	S	S	G	L	V	V	R	W	V	V	A	S	A	L	G	G	P
Secondary structure
SS confidence
Disorder												?	?																													?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	L	M	A	A	I	A	L	A	V	I	H	D	A	S	S	V	V	T	E	L	Q	T	P	S	A	L	R	A	F	T	S	V	L	V	V	H	S	V	G	A	A	T	G	V	W	S	R	V	G	R	R	A	L	A	A	T	A	L	P
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?																			?	?	?	?		?	?					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	W	L	H	D	S	M	R	A	A	A	A	G	V	L	A	L	L	G	L	S	G	V	V	T	A	G	S	L	V	V	H	W	A	T	M	Q	E	L	Y	G	I	T	D	S	I	F	G	Q	F	S	L	T	V	L	S	V	L	Y	A
Secondary structure
SS confidence
Disorder																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	N	V	I	V	G	T	S	A	I	A	V	G	S	S	A	H	I	G	F	A	T	F	S	S	F	A	V	L	G	G	D	I	P	A	L	P	I	L	A	A	A	P	T	P	P	L	G	P	A	W	V	A	L	L	I	V	G	A	S
Secondary structure
SS confidence
Disorder																												?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	G	V	A	V	G	Q	Q	C	A	R	R	A	L	P	F	V	A	A	M	A	K	L	L	V	A	A	V	A	G	A	L	V	M	A	V	L	G	Y	G	G	G	G	R	L	G	N	F	G	D	V	G	V	D	E	G	A	L	V	L
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?																						?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	V	L	F	W	F	T	F	V	G	W	V	T	V	V	I	A	G	G	I	S	R	R	P	K	R	L	R	P	A	P	P	V	E	L	D	A	D	E	S	S	P	P	V	D	M	F	D	G	A	A	S	E	Q	P	P	A	S	V	A
Secondary structure
SS confidence
Disorder																			?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.
Sequence		E	D	V	P	P	S	H	D	D	I	A	N	G	L	K	A	P	T	A	D	D	E	A	L	P	L	S	D	E	P	P	P	R	A	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 32%) Alpha helix ( 61%) Beta strand ( 3%) TM helix ( 47%) (View membrane topology prediction)

Rank Aligned region

PDB 2n28 chain A Region: 229 - 251 Aligned: 23 Modelled: 23 Confidence: 22.2% Identity: 22% PDB header:viral protein Chain: A: PDB Molecule:protein vpu; PDBTitle: solid-state nmr structure of vpu Phyre2 PDB 2cse chain W Region: 380 - 455 Aligned: 76 Modelled: 76 Confidence: 16.9% Identity: 16% PDB header:virus Chain: W: PDB Molecule:major core protein lambda 1; PDBTitle: features of reovirus outer-capsid protein mu1 revealed by2 electron and image reconstruction of the virion at 7.0-a3 resolution Phyre2 PDB 4nfu chain B Region: 44 - 67 Aligned: 24 Modelled: 24 Confidence: 16.1% Identity: 17% PDB header:signaling protein Chain: B: PDB Molecule:senescence-associated carboxylesterase 101; PDBTitle: structure of the central plant immunity signaling node eds1 in complex2 with its interaction partner sag101 Phyre2 PDB 4nfu chain A Region: 44 - 67 Aligned: 24 Modelled: 24 Confidence: 15.6% Identity: 17% PDB header:signaling protein Chain: A: PDB Molecule:eds1; PDBTitle: structure of the central plant immunity signaling node eds1 in complex2 with its interaction partner sag101 Phyre2 PDB 6hu9 chain U Region: 239 - 253 Aligned: 15 Modelled: 15 Confidence: 11.9% Identity: 40% PDB header:oxidoreductase/electron transport Chain: U: PDB Molecule:cytochrome b-c1 complex subunit 10; PDBTitle: iii2-iv2 mitochondrial respiratory supercomplex from s. cerevisiae Phyre2 PDB 6hcy chain A Region: 230 - 245 Aligned: 16 Modelled: 16 Confidence: 10.8% Identity: 44% PDB header:membrane protein Chain: A: PDB Molecule:metalloreductase steap4; PDBTitle: human steap4 bound to nadp, fad, heme and fe(iii)-nta. Phyre2 PDB 5xpd chain A Region: 400 - 446 Aligned: 47 Modelled: 47 Confidence: 10.8% Identity: 4% PDB header:transport protein Chain: A: PDB Molecule:sugar transporter; PDBTitle: sugar transporter of atsweet13 in inward-facing state with a substrate2 analog Phyre2 PDB 3trs chain A Region: 246 - 272 Aligned: 27 Modelled: 27 Confidence: 7.5% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:aspergillopepsin-2 light chain; PDBTitle: the crystal structure of aspergilloglutamic peptidase from aspergillus2 niger Phyre2 1 c2n28A_ 2 c2cseW_ 3 c4nfuB_ 4 c4nfuA_ 5 c6hu9U_ 6 c6hcyA_ 7 c5xpdA_ 8 c3trsA_