1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	T	D	D	G	R	R	P	I	R	R	A	L	I	S	V	Y	D	K	T	G	L	V	D	L	A	Q	G	L	S	A	A	G	V	E	I	I	S	T	G	S	T	A	K	T	I	A	D	T	G	I	P	V	T	P	V	E	Q	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	G	F	P	E	V	L	D	G	R	V	K	T	L	H	P	R	V	H	A	G	L	L	A	D	L	R	K	S	E	H	A	A	A	L	E	Q	L	G	I	E	A	F	E	L	V	V	V	N	L	Y	P	F	S	Q	T	V	E	S	G
Secondary structure
SS confidence
Disorder																									?	?	?	?	?										?																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	S	V	D	D	C	V	E	Q	I	D	I	G	G	P	A	M	V	R	A	A	A	K	N	H	P	S	A	A	V	V	T	D	P	L	G	Y	H	G	V	L	A	A	L	R	A	G	G	F	T	L	A	E	R	K	R	L	A	S	L
Secondary structure
SS confidence
Disorder																																																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	F	Q	H	I	A	E	Y	D	I	A	V	A	S	W	M	Q	Q	T	L	A	P	E	H	P	V	A	A	F	P	Q	W	F	G	R	S	W	R	R	V	A	M	L	R	Y	G	E	N	P	H	Q	Q	A	A	L	Y	G	D	P	T
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?	?												?					?													?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	W	P	G	L	A	Q	A	E	Q	L	H	G	K	D	M	S	Y	N	N	F	T	D	A	D	A	A	W	R	A	A	F	D	H	E	Q	T	C	V	A	I	I	K	H	A	N	P	C	G	I	A	I	S	S	V	S	V	A	D	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		H	R	K	A	H	E	C	D	P	L	S	A	Y	G	G	V	I	A	A	N	T	E	V	S	V	E	M	A	E	Y	V	S	T	I	F	T	E	V	I	V	A	P	G	Y	A	P	G	A	L	D	V	L	A	R	K	K	N	I	R	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	V	A	A	E	P	L	A	G	G	S	E	L	R	P	I	S	G	G	L	L	I	Q	Q	S	D	Q	L	D	A	H	G	D	N	P	A	N	W	T	L	A	T	G	S	P	A	D	P	A	T	L	T	D	L	V	F	A	W	R	A
Secondary structure
SS confidence
Disorder							?	?	?	?																		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		C	R	A	V	K	S	N	A	I	V	I	A	A	D	G	A	T	V	G	V	G	M	G	Q	V	N	R	V	D	A	A	R	L	A	V	E	R	G	G	E	R	V	R	G	A	V	A	A	S	D	A	F	F	P	F	P	D	G	L	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.
Sequence		T	L	A	A	A	G	V	T	A	V	V	H	P	G	G	S	V	R	D	E	E	V	T	E	A	A	A	K	A	G	V	T	L	Y	L	T	G	A	R	H	F	A	H
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 36%) Beta strand ( 22%)

Rank Aligned region

PDB 4a1o chain B Region: 7 - 523 Aligned: 517 Modelled: 517 Confidence: 100.0% Identity: 100% PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. Phyre2 PDB 1thz chain A Region: 10 - 523 Aligned: 491 Modelled: 500 Confidence: 100.0% Identity: 38% PDB header:transferase, hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of avian aicar transformylase in complex2 with a novel inhibitor identified by virtual ligand3 screening Phyre2 PDB 4ehi chain B Region: 8 - 523 Aligned: 486 Modelled: 511 Confidence: 100.0% Identity: 39% PDB header:hydrolase,transferase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: an x-ray crystal structure of a putative bifunctional2 phosphoribosylaminoimidazolecarboxamide formyltransferase/imp3 cyclohydrolase Phyre2 PDB 1zcz chain A Region: 10 - 523 Aligned: 452 Modelled: 452 Confidence: 100.0% Identity: 40% PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution Phyre2 PDB 1zcz chain A domain 2 Region: 213 - 523 Aligned: 294 Modelled: 311 Confidence: 100.0% Identity: 43% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1g8m chain A domain 2 Region: 217 - 523 Aligned: 299 Modelled: 307 Confidence: 100.0% Identity: 32% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1pkx chain A domain 2 Region: 219 - 523 Aligned: 298 Modelled: 305 Confidence: 100.0% Identity: 33% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1pkx chain A domain 1 Region: 9 - 203 Aligned: 194 Modelled: 195 Confidence: 100.0% Identity: 45% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Inosicase Phyre2 PDB 1g8m chain A domain 1 Region: 10 - 202 Aligned: 192 Modelled: 193 Confidence: 100.0% Identity: 45% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Inosicase Phyre2 PDB 6nko chain A Region: 12 - 201 Aligned: 188 Modelled: 190 Confidence: 100.0% Identity: 35% PDB header:unknown function Chain: A: PDB Molecule:forh; PDBTitle: crystal structure of forh Phyre2 PDB 1zcz chain A domain 1 Region: 10 - 198 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 36% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Inosicase Phyre2 PDB 1a9x chain A domain 2 Region: 5 - 148 Aligned: 123 Modelled: 124 Confidence: 99.4% Identity: 22% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain Phyre2 PDB 2yvq chain A Region: 1 - 165 Aligned: 122 Modelled: 129 Confidence: 99.3% Identity: 17% PDB header:ligase Chain: A: PDB Molecule:carbamoyl-phosphate synthase; PDBTitle: crystal structure of mgs domain of carbamoyl-phosphate2 synthetase from homo sapiens Phyre2 PDB 1wo8 chain A domain 1 Region: 10 - 169 Aligned: 117 Modelled: 119 Confidence: 98.6% Identity: 25% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Methylglyoxal synthase, MgsA Phyre2 PDB 5dot chain A Region: 4 - 173 Aligned: 132 Modelled: 154 Confidence: 98.5% Identity: 18% PDB header:ligase Chain: A: PDB Molecule:carbamoyl-phosphate synthase [ammonia], mitochondrial; PDBTitle: crystal structure of human carbamoyl phosphate synthetase i (cps1),2 apo form Phyre2 PDB 5dou chain C Region: 4 - 171 Aligned: 129 Modelled: 152 Confidence: 98.4% Identity: 19% PDB header:ligase Chain: C: PDB Molecule:carbamoyl-phosphate synthase [ammonia], mitochondrial; PDBTitle: crystal structure of human carbamoyl phosphate synthetase i (cps1),2 ligand-bound form Phyre2 PDB 1m6v chain E Region: 12 - 168 Aligned: 113 Modelled: 119 Confidence: 98.2% Identity: 29% PDB header:ligase Chain: E: PDB Molecule:carbamoyl phosphate synthetase large chain; PDBTitle: crystal structure of the g359f (small subunit) point mutant of2 carbamoyl phosphate synthetase Phyre2 PDB 6f2c chain K Region: 18 - 165 Aligned: 108 Modelled: 127 Confidence: 98.0% Identity: 23% PDB header:lyase Chain: K: PDB Molecule:methylglyoxal synthase; PDBTitle: methylglyoxal synthase mgsa from bacillus subtilis Phyre2 PDB 1vmd chain A Region: 18 - 162 Aligned: 105 Modelled: 124 Confidence: 97.1% Identity: 22% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Methylglyoxal synthase, MgsA Phyre2 PDB 4ggm chain X Region: 400 - 514 Aligned: 110 Modelled: 115 Confidence: 97.1% Identity: 24% PDB header:hydrolase Chain: X: PDB Molecule:udp-2,3-diacylglucosamine pyrophosphatase lpxi; PDBTitle: structure of lpxi Phyre2 1 c4a1oB_ 2 c1thzA_ 3 c4ehiB_ 4 c1zczA_ 5 d1zcza2 6 d1g8ma2 7 d1pkxa2 8 d1pkxa1 9 d1g8ma1 10 c6nkoA_ 11 d1zcza1 12 d1a9xa2 13 c2yvqA_ 14 d1wo8a1 15 c5dotA_ 16 c5douC_ 17 c1m6vE_ 18 c6f2cK_ 19 d1vmda_ 20 c4ggmX_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213