1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	V	N	R	P	Q	C	A	R	V	P	Y	S	A	E	S	L	V	R	V	E	A	S	W	Y	G	R	T	L	R	A	I	P	E	V	L	S	Q	V	G	Y	Q	Q	A	D	H	G	E	S	L	L	T	S	H	H	C	C	L	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																												?	?				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	E	G	A	R	P	G	W	V	G	S	S	A	G	A	L	S	G	L	L	D	S	W	A	E	A	S	T	A	H	A	A	R	I	G	D	H	S	Y	G	M	H	L	A	A	V	G	F	A	E	M	E	E	H	N	A	A	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?																																									?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.
Sequence		A	A	V	Y	P	T	G	G	G	S	A	R	C	D	G	V	D	V	S
Secondary structure
SS confidence
Disorder		?	?		?	?	?		?		?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 34%) Alpha helix ( 65%) Beta strand ( 9%)

Rank Aligned region

PDB 3zbh chain C Region: 34 - 120 Aligned: 87 Modelled: 87 Confidence: 96.2% Identity: 15% PDB header:unknown function Chain: C: PDB Molecule:esxa; PDBTitle: geobacillus thermodenitrificans esxa crystal form i Phyre2 PDB 1wa8 chain A domain 1 Region: 34 - 122 Aligned: 89 Modelled: 89 Confidence: 95.8% Identity: 18% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 3gvm chain A Region: 34 - 120 Aligned: 87 Modelled: 87 Confidence: 95.5% Identity: 13% PDB header:viral protein Chain: A: PDB Molecule:putative uncharacterized protein sag1039; PDBTitle: structure of the homodimeric wxg-100 family protein from streptococcus2 agalactiae Phyre2 PDB 4lws chain A Region: 30 - 123 Aligned: 94 Modelled: 94 Confidence: 95.3% Identity: 11% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 2kg7 chain B Region: 61 - 121 Aligned: 61 Modelled: 61 Confidence: 88.9% Identity: 11% PDB header:unknown function Chain: B: PDB Molecule:esat-6-like protein esxh; PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288 Phyre2 PDB 2vs0 chain B Region: 34 - 111 Aligned: 78 Modelled: 78 Confidence: 87.9% Identity: 10% PDB header:cell invasion Chain: B: PDB Molecule:virulence factor esxa; PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa Phyre2 PDB 1wa8 chain B domain 1 Region: 61 - 121 Aligned: 61 Modelled: 61 Confidence: 86.4% Identity: 18% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 4iog chain D Region: 34 - 111 Aligned: 78 Modelled: 78 Confidence: 80.1% Identity: 14% PDB header:unknown function Chain: D: PDB Molecule:secreted protein esxb; PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne Phyre2 PDB 4lws chain B Region: 30 - 109 Aligned: 80 Modelled: 80 Confidence: 63.1% Identity: 18% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 4i0x chain J Region: 49 - 97 Aligned: 49 Modelled: 49 Confidence: 42.1% Identity: 18% PDB header:structural genomics, unknown function Chain: J: PDB Molecule:esat-6-like protein mab_3113; PDBTitle: crystal structure of the mycobacterum abscessus esxef (mab_3112-2 mab_3113) complex Phyre2 PDB 2fef chain A domain 1 Region: 77 - 113 Aligned: 37 Modelled: 37 Confidence: 13.5% Identity: 30% Fold: Bromodomain-like Superfamily: PA2201 N-terminal domain-like Family: PA2201 N-terminal domain-like Phyre2 PDB 4xwh chain A Region: 35 - 112 Aligned: 70 Modelled: 78 Confidence: 11.4% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:alpha-n-acetylglucosaminidase; PDBTitle: crystal structure of the human n-acetyl-alpha-glucosaminidase Phyre2 PDB 2p7v chain A Region: 78 - 92 Aligned: 15 Modelled: 15 Confidence: 11.3% Identity: 20% PDB header:transcription Chain: A: PDB Molecule:regulator of sigma d; PDBTitle: crystal structure of the escherichia coli regulator of sigma 70, rsd,2 in complex with sigma 70 domain 4 Phyre2 PDB 6icz chain X Region: 70 - 95 Aligned: 26 Modelled: 26 Confidence: 8.8% Identity: 35% PDB header:splicing Chain: X: PDB Molecule:prkr-interacting protein 1; PDBTitle: cryo-em structure of a human post-catalytic spliceosome (p complex) at2 3.0 angstrom Phyre2 PDB 5vko chain B Region: 11 - 17 Aligned: 7 Modelled: 7 Confidence: 8.8% Identity: 86% PDB header:transcription Chain: B: PDB Molecule:dna-directed rna polymerase ii subunit rpb1; PDBTitle: spt6 tsh2-rpb1 1468-1500 pt1471, ps1493 Phyre2 PDB 1v8d chain A Region: 95 - 104 Aligned: 10 Modelled: 10 Confidence: 7.8% Identity: 60% Fold: TTHA0583/YokD-like Superfamily: TTHA0583/YokD-like Family: Hypothetical protein TT1679 Phyre2 PDB 1v8d chain C Region: 95 - 104 Aligned: 10 Modelled: 10 Confidence: 7.6% Identity: 60% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:hypothetical protein (tt1679); PDBTitle: crystal structure of the conserved hypothetical protein2 tt1679 from thermus thermophilus Phyre2 PDB 2vcb chain A Region: 35 - 112 Aligned: 70 Modelled: 78 Confidence: 6.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:alpha-n-acetylglucosaminidase; PDBTitle: family 89 glycoside hydrolase from clostridium perfringens2 in complex with pugnac Phyre2 PDB 3faj chain A Region: 33 - 45 Aligned: 13 Modelled: 13 Confidence: 6.6% Identity: 54% PDB header:structural protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of the structural protein p131 of the archaeal virus2 acidianus two-tailed virus (atv) Phyre2 PDB 1v7r chain A Region: 107 - 119 Aligned: 13 Modelled: 13 Confidence: 6.2% Identity: 62% Fold: Anticodon-binding domain-like Superfamily: ITPase-like Family: ITPase (Ham1) Phyre2 1 c3zbhC_ 2 d1wa8a1 3 c3gvmA_ 4 c4lwsA_ 5 c2kg7B_ 6 c2vs0B_ 7 d1wa8b1 8 c4iogD_ 9 c4lwsB_ 10 c4i0xJ_ 11 d2fefa1 12 c4xwhA_ 13 c2p7vA_ 14 c6iczX_ 15 c5vkoB_ 16 d1v8da_ 17 c1v8dC_ 18 c2vcbA_ 19 c3fajA_ 20 d1v7ra_ 21 22 23 24