1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	I	G	N	C	S	G	F	Y	G	D	R	L	S	A	M	R	E	M	L	T	G	G	E	L	D	Y	L	T	G	D	Y	L	A	E	L	T	M	L	I	L	G	R	D	R	M	K	N	P	D	R	G	Y	A	K	T	F	L	A
Secondary structure
SS confidence
Disorder		?			?		?	?																																									?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	L	E	D	C	L	G	L	A	H	D	R	G	V	R	I	V	T	N	A	G	G	L	N	P	A	G	L	A	N	A	V	R	A	L	A	A	R	L	G	I	P	A	Q	V	A	H	V	E	G	D	D	L	Q	P	R	A	A	E	L
Secondary structure
SS confidence
Disorder																																								?												?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	L	G	T	P	L	T	A	N	A	Y	L	G	A	W	G	I	V	D	C	F	E	R	G	A	D	V	V	V	T	G	R	V	T	D	A	S	V	V	V	G	A	A	A	A	H	F	G	W	G	R	T	D	Y	H	R	L	A	G	A
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	V	A	G	H	V	I	E	C	G	V	Q	A	T	G	G	N	Y	A	F	F	T	E	I	G	D	L	T	H	A	G	F	P	L	A	E	I	A	A	D	G	S	S	V	I	T	K	H	H	G	T	G	G	L	V	S	V	D	T	I
Secondary structure
SS confidence
Disorder																																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	A	Q	L	L	Y	E	I	T	G	A	R	Y	A	N	P	D	V	T	A	R	M	D	S	V	E	L	S	P	D	G	P	D	R	V	R	I	S	G	V	I	G	E	P	P	P	P	T	Y	K	V	S	L	N	S	I	G	G	F	R
Secondary structure
SS confidence
Disorder																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		N	A	M	T	F	V	L	T	G	L	D	I	D	A	K	A	D	L	V	R	R	Q	L	E	A	A	L	T	V	K	P	A	E	L	Q	W	T	L	A	R	T	D	H	P	D	A	D	T	E	E	T	A	S	A	L	L	T	C	V	A
Secondary structure
SS confidence
Disorder																														?															?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	D	P	D	P	A	N	V	G	R	Q	F	S	S	A	A	V	E	L	A	L	A	S	Y	P	G	F	T	A	T	A	P	P	G	D	G	Q	V	Y	G	V	F	T	P	G	Y	V	D	A	G	K	V	A	H	I	A	V	H	A	D
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?	?	?	?	?	?			?				?	?			?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		G	T	R	T	E	I	P	C	A	T	E	T	L	E	L	A	P	A	H	P	P	A	L	P	D	P	L	P	A	G	P	T	R	R	V	P	L	G	L	I	A	G	A	R	S	G	D	K	G	G	S	A	N	V	G	V	W	V	R	T
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		D	E	Q	W	R	W	L	A	H	T	L	T	V	E	L	L	K	E	L	L	P	E	T	A	G	L	V	V	T	R	H	V	L	P	N	L	R	A	L	N	F	V	I	E	A	I	L	G	Q	G	V	A	Y	Q	A	R	F	D	P	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence		A	K	G	L	G	E	W	L	R	S	R	H	V	E	I	P	E	T	L	L
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 31%) Beta strand ( 30%)

Rank Aligned region

PDB 3gnd chain C Region: 49 - 152 Aligned: 103 Modelled: 104 Confidence: 94.4% Identity: 14% PDB header:lyase Chain: C: PDB Molecule:aldolase lsrf; PDBTitle: crystal structure of e. coli lsrf in complex with ribulose-5-phosphate Phyre2 PDB 1ojx chain A Region: 50 - 152 Aligned: 103 Modelled: 103 Confidence: 93.3% Identity: 15% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 2qjh chain H Region: 49 - 152 Aligned: 104 Modelled: 104 Confidence: 87.7% Identity: 17% PDB header:lyase Chain: H: PDB Molecule:putative aldolase mj0400; PDBTitle: m. jannaschii adh synthase covalently bound to2 dihydroxyacetone phosphate Phyre2 PDB 1rr2 chain A Region: 9 - 148 Aligned: 123 Modelled: 123 Confidence: 86.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:transcarboxylase 5s subunit; PDBTitle: propionibacterium shermanii transcarboxylase 5s subunit bound to 2-2 ketobutyric acid Phyre2 PDB 5n2p chain A Region: 62 - 152 Aligned: 88 Modelled: 91 Confidence: 85.5% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: sulfolobus solfataricus tryptophan synthase a Phyre2 PDB 5kzm chain A Region: 38 - 151 Aligned: 111 Modelled: 114 Confidence: 84.2% Identity: 25% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: crystal structure of tryptophan synthase alpha-beta chain complex from2 francisella tularensis Phyre2 PDB 4lrt chain C Region: 54 - 148 Aligned: 78 Modelled: 95 Confidence: 83.3% Identity: 27% PDB header:lyase/oxidoreductase Chain: C: PDB Molecule:4-hydroxy-2-oxovalerate aldolase; PDBTitle: crystal and solution structures of the bifunctional enzyme2 (aldolase/aldehyde dehydrogenase) from thermomonospora curvata,3 reveal a cofactor-binding domain motion during nad+ and coa4 accommodation whithin the shared cofactor-binding site Phyre2 PDB 3tfx chain B Region: 60 - 152 Aligned: 93 Modelled: 91 Confidence: 81.8% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:orotidine 5'-phosphate decarboxylase; PDBTitle: crystal structure of orotidine 5'-phosphate decarboxylase from2 lactobacillus acidophilus Phyre2 PDB 4euh chain A Region: 83 - 156 Aligned: 58 Modelled: 58 Confidence: 81.5% Identity: 26% PDB header:oxidoreductase Chain: A: PDB Molecule:putative reductase ca_c0462; PDBTitle: crystal structure of clostridium acetobutulicum trans-2-enoyl-coa2 reductase apo form Phyre2 PDB 5ks8 chain F Region: 54 - 148 Aligned: 76 Modelled: 77 Confidence: 79.2% Identity: 20% PDB header:ligase Chain: F: PDB Molecule:pyruvate carboxylase subunit beta; PDBTitle: crystal structure of two-subunit pyruvate carboxylase from2 methylobacillus flagellatus Phyre2 PDB 3bg3 chain A Region: 28 - 150 Aligned: 104 Modelled: 106 Confidence: 76.5% Identity: 26% PDB header:ligase Chain: A: PDB Molecule:pyruvate carboxylase, mitochondrial; PDBTitle: crystal structure of human pyruvate carboxylase (missing the biotin2 carboxylase domain at the n-terminus) Phyre2 PDB 1o94 chain C Region: 55 - 170 Aligned: 99 Modelled: 104 Confidence: 74.6% Identity: 15% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 4jn6 chain C Region: 10 - 148 Aligned: 122 Modelled: 122 Confidence: 74.1% Identity: 24% PDB header:lyase/oxidoreductase Chain: C: PDB Molecule:4-hydroxy-2-oxovalerate aldolase; PDBTitle: crystal structure of the aldolase-dehydrogenase complex from2 mycobacterium tuberculosis hrv37 Phyre2 PDB 5ey5 chain A Region: 36 - 151 Aligned: 113 Modelled: 116 Confidence: 73.8% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:lbcats-a; PDBTitle: lbcats Phyre2 PDB 1ydo chain C Region: 54 - 148 Aligned: 77 Modelled: 78 Confidence: 70.7% Identity: 23% PDB header:lyase Chain: C: PDB Molecule:hmg-coa lyase; PDBTitle: crystal structure of the bacillis subtilis hmg-coa lyase, northeast2 structural genomics target sr181. Phyre2 PDB 1t1r chain A domain 2 Region: 63 - 168 Aligned: 100 Modelled: 106 Confidence: 70.1% Identity: 15% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 3bg3 chain B Region: 53 - 157 Aligned: 94 Modelled: 105 Confidence: 70.0% Identity: 14% PDB header:ligase Chain: B: PDB Molecule:pyruvate carboxylase, mitochondrial; PDBTitle: crystal structure of human pyruvate carboxylase (missing the biotin2 carboxylase domain at the n-terminus) Phyre2 PDB 1efp chain B Region: 55 - 169 Aligned: 100 Modelled: 115 Confidence: 69.9% Identity: 18% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 4nu7 chain C Region: 59 - 152 Aligned: 91 Modelled: 94 Confidence: 69.4% Identity: 18% PDB header:isomerase Chain: C: PDB Molecule:ribulose-phosphate 3-epimerase; PDBTitle: 2.05 angstrom crystal structure of ribulose-phosphate 3-epimerase from2 toxoplasma gondii. Phyre2 PDB 3h75 chain A Region: 9 - 151 Aligned: 143 Modelled: 143 Confidence: 68.3% Identity: 20% PDB header:sugar binding protein Chain: A: PDB Molecule:periplasmic sugar-binding domain protein; PDBTitle: crystal structure of a periplasmic sugar-binding protein from the2 pseudomonas fluorescens Phyre2 1 c3gndC_ 2 d1ojxa_ 3 c2qjhH_ 4 c1rr2A_ 5 c5n2pA_ 6 c5kzmA_ 7 c4lrtC_ 8 c3tfxB_ 9 c4euhA_ 10 c5ks8F_ 11 c3bg3A_ 12 d1o94c_ 13 c4jn6C_ 14 c5ey5A_ 15 c1ydoC_ 16 d1t1ra2 17 c3bg3B_ 18 d1efpb_ 19 c4nu7C_ 20 c3h75A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301