1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	S	V	E	E	Q	Q	A	R	I	S	A	A	A	V	A	P	R	P	I	R	V	A	I	A	E	A	Q	G	L	M	C	A	E	E	V	V	T	E	R	P	M	P	G	F	D	Q	A	A	I	D	G	Y	A	V	R	S	V	D
Secondary structure
SS confidence
Disorder		?	?	?												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	G	V	G	D	T	G	G	V	Q	V	F	A	D	H	G	D	L	D	G	R	D	V	L	T	L	P	V	M	G	T	I	E	A	G	A	R	T	L	S	R	L	Q	P	R	Q	A	V	R	V	Q	T	G	A	P	L	P	T	L
Secondary structure
SS confidence
Disorder							?	?					?		?	?	?	?	?	?	?	?	?	?															?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	D	A	V	L	P	L	R	W	T	D	G	G	M	S	R	V	R	V	L	R	G	A	P	S	G	A	Y	V	R	R	A	G	D	D	V	Q	P	G	D	V	A	V	R	A	G	T	I	I	G	A	A	Q	V	G	L	L	A	A	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	R	E	R	V	L	V	H	P	R	P	R	L	S	V	M	A	V	G	G	E	L	V	D	I	S	R	T	P	G	N	G	Q	V	Y	D	V	N	S	Y	A	L	A	A	A	G	R	D	A	C	A	E	V	N	R	V	G	I	V	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	D	P	T	E	L	G	E	I	V	E	G	Q	L	N	R	A	E	V	V	V	I	A	G	G	V	G	G	A	A	A	E	A	V	R	S	V	L	S	E	L	G	E	M	E	V	V	R	V	A	M	H	P	G	S	V	Q	G	F	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	L	G	R	D	G	V	P	T	F	L	L	P	A	N	P	V	S	A	L	V	V	F	E	V	M	V	R	P	L	I	R	L	S	L	G	K	R	H	P	M	R	R	I	V	S	A	R	T	L	S	P	I	T	S	V	A	G	R	K
Secondary structure
SS confidence
Disorder																																									?	?	?								?	?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	Y	L	R	G	Q	L	M	R	D	Q	D	S	G	E	Y	L	V	Q	A	L	G	G	A	P	G	A	S	S	H	L	L	A	T	L	A	E	A	N	C	L	V	V	V	P	T	G	A	E	Q	I	R	T	G	E	I	V	D	V	A
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?																					?	?
Disorder confidence
		.	.	.	.	.	.
Sequence		F	L	A	Q	H	G
Secondary structure
SS confidence
Disorder				?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 21%) Beta strand ( 32%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 2nqq chain A Region: 1 - 424 Aligned: 398 Modelled: 404 Confidence: 100.0% Identity: 30% PDB header:biosynthetic protein Chain: A: PDB Molecule:molybdopterin biosynthesis protein moea; PDBTitle: moea r137q Phyre2 PDB 5g2r chain A Region: 1 - 424 Aligned: 397 Modelled: 402 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:molybdopterin biosynthesis protein cnx1; PDBTitle: crystal structure of the mo-insertase domain cnx1e from2 arabidopsis thaliana Phyre2 PDB 1uz5 chain A Region: 1 - 425 Aligned: 390 Modelled: 408 Confidence: 100.0% Identity: 31% PDB header:molybdopterin biosynthesis Chain: A: PDB Molecule:402aa long hypothetical molybdopterin PDBTitle: the crystal structure of molybdopterin biosynthesis moea2 protein from pyrococcus horikosii Phyre2 PDB 2fu3 chain A Region: 1 - 424 Aligned: 386 Modelled: 392 Confidence: 100.0% Identity: 32% PDB header:biosynthetic protein/structural protein Chain: A: PDB Molecule:gephyrin; PDBTitle: crystal structure of gephyrin e-domain Phyre2 PDB 1wu2 chain B Region: 1 - 422 Aligned: 375 Modelled: 385 Confidence: 100.0% Identity: 27% PDB header:structural genomics,biosynthetic protein Chain: B: PDB Molecule:molybdopterin biosynthesis moea protein; PDBTitle: crystal structure of molybdopterin biosynthesis moea2 protein from pyrococcus horikoshii ot3 Phyre2 PDB 1uz5 chain A domain 2 Region: 1 - 190 Aligned: 175 Modelled: 175 Confidence: 100.0% Identity: 31% Fold: MoeA N-terminal region -like Superfamily: MoeA N-terminal region -like Family: MoeA N-terminal region -like Phyre2 PDB 1wu2 chain A domain 2 Region: 1 - 188 Aligned: 173 Modelled: 173 Confidence: 100.0% Identity: 30% Fold: MoeA N-terminal region -like Superfamily: MoeA N-terminal region -like Family: MoeA N-terminal region -like Phyre2 PDB 2nqr chain A domain 2 Region: 1 - 190 Aligned: 170 Modelled: 170 Confidence: 100.0% Identity: 29% Fold: MoeA N-terminal region -like Superfamily: MoeA N-terminal region -like Family: MoeA N-terminal region -like Phyre2 PDB 2fts chain A domain 2 Region: 1 - 189 Aligned: 167 Modelled: 167 Confidence: 100.0% Identity: 34% Fold: MoeA N-terminal region -like Superfamily: MoeA N-terminal region -like Family: MoeA N-terminal region -like Phyre2 PDB 2nqr chain A domain 3 Region: 191 - 340 Aligned: 148 Modelled: 150 Confidence: 100.0% Identity: 32% Fold: Molybdenum cofactor biosynthesis proteins Superfamily: Molybdenum cofactor biosynthesis proteins Family: MoeA central domain-like Phyre2 PDB 2fts chain A domain 3 Region: 191 - 341 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 30% Fold: Molybdenum cofactor biosynthesis proteins Superfamily: Molybdenum cofactor biosynthesis proteins Family: MoeA central domain-like Phyre2 PDB 1uz5 chain A domain 3 Region: 191 - 338 Aligned: 141 Modelled: 146 Confidence: 100.0% Identity: 38% Fold: Molybdenum cofactor biosynthesis proteins Superfamily: Molybdenum cofactor biosynthesis proteins Family: MoeA central domain-like Phyre2 PDB 1wu2 chain A domain 3 Region: 190 - 340 Aligned: 133 Modelled: 151 Confidence: 100.0% Identity: 24% Fold: Molybdenum cofactor biosynthesis proteins Superfamily: Molybdenum cofactor biosynthesis proteins Family: MoeA central domain-like Phyre2 PDB 2pjk chain A Region: 189 - 336 Aligned: 146 Modelled: 148 Confidence: 100.0% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:178aa long hypothetical molybdenum cofactor PDBTitle: structure of hypothetical molybdenum cofactor biosynthesis2 protein b from sulfolobus tokodaii Phyre2 PDB 1xi8 chain A domain 3 Region: 190 - 340 Aligned: 113 Modelled: 119 Confidence: 100.0% Identity: 25% Fold: Molybdenum cofactor biosynthesis proteins Superfamily: Molybdenum cofactor biosynthesis proteins Family: MoeA central domain-like Phyre2 PDB 1y5e chain A domain 1 Region: 189 - 336 Aligned: 137 Modelled: 148 Confidence: 100.0% Identity: 18% Fold: Molybdenum cofactor biosynthesis proteins Superfamily: Molybdenum cofactor biosynthesis proteins Family: MogA-like Phyre2 PDB 1mkz chain A Region: 188 - 347 Aligned: 149 Modelled: 158 Confidence: 100.0% Identity: 15% Fold: Molybdenum cofactor biosynthesis proteins Superfamily: Molybdenum cofactor biosynthesis proteins Family: MogA-like Phyre2 PDB 2is8 chain A Region: 192 - 339 Aligned: 139 Modelled: 148 Confidence: 100.0% Identity: 22% PDB header:structural protein Chain: A: PDB Molecule:molybdopterin biosynthesis enzyme, moab; PDBTitle: crystal structure of the molybdopterin biosynthesis enzyme moab2 (ttha0341) from thermus theromophilus hb8 Phyre2 PDB 1jlj chain A Region: 189 - 336 Aligned: 138 Modelled: 148 Confidence: 99.9% Identity: 17% Fold: Molybdenum cofactor biosynthesis proteins Superfamily: Molybdenum cofactor biosynthesis proteins Family: MogA-like Phyre2 PDB 2qq1 chain A Region: 189 - 343 Aligned: 146 Modelled: 155 Confidence: 99.9% Identity: 15% PDB header:structural protein Chain: A: PDB Molecule:molybdenum cofactor biosynthesis mog; PDBTitle: crystal structure of molybdenum cofactor biosynthesis2 (aq_061) other form from aquifex aeolicus vf5 Phyre2 1 c2nqqA_ 2 c5g2rA_ 3 c1uz5A_ 4 c2fu3A_ 5 c1wu2B_ 6 d1uz5a2 7 d1wu2a2 8 d2nqra2 9 d2ftsa2 10 d2nqra3 11 d2ftsa3 12 d1uz5a3 13 d1wu2a3 14 c2pjkA_ 15 d1xi8a3 16 d1y5ea1 17 d1mkza_ 18 c2is8A_ 19 d1jlja_ 20 c2qq1A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499