1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	V	E	L	G	S	N	S	E	V	G	A	L	R	V	V	I	L	H	R	P	G	A	E	L	R	R	L	T	P	R	N	T	D	Q	L	L	F	D	G	L	P	W	V	S	R	A	Q	D	E	H	D	E	F	A	E	L	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	R	G	A	E	V	L	L	L	S	D	L	L	T	E	A	L	H	H	S	G	A	A	R	M	Q	G	I	A	A	A	V	D	A	P	R	L	G	L	P	L	A	Q	E	L	S	A	Y	L	R	S	L	D	P	G	R	L	A	H	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	T	A	G	M	T	F	N	E	L	P	S	D	T	R	T	D	V	S	L	V	L	R	M	H	H	G	G	D	F	V	I	E	P	L	P	N	L	V	F	T	R	D	S	S	I	W	I	G	P	R	V	V	I	P	S	L	A	L	R
Secondary structure
SS confidence
Disorder							?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	R	V	R	E	A	S	L	T	D	L	I	Y	A	H	H	P	R	F	T	G	V	R	R	A	Y	E	S	R	T	A	P	V	E	G	G	D	V	L	L	L	A	P	G	V	V	A	V	G	V	G	E	R	T	T	P	A	G	A	E
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	L	A	R	S	L	F	D	D	D	L	A	H	T	V	L	A	V	P	I	A	Q	Q	R	A	Q	M	H	L	D	T	V	C	T	M	V	D	T	D	T	M	V	M	Y	A	N	V	V	D	T	L	E	A	F	T	I	Q	R	T	P
Secondary structure
SS confidence
Disorder																																																				?		?							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	G	V	T	I	G	D	A	A	P	F	A	E	A	A	A	K	A	M	G	I	D	K	L	R	V	I	H	T	G	M	D	P	V	V	A	E	R	E	Q	W	D	D	G	N	N	T	L	A	L	A	P	G	V	V	V	A	Y	E	R
Secondary structure
SS confidence
Disorder			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.
Sequence		N	V	Q	T	N	A	R	L	Q	D	A	G	I	E	V	L	T	I	A	G	S	E	L	G	T	G	R	G	G	P	R	C	M	S	C	P	A	A	R	D	P	L
Secondary structure
SS confidence
Disorder																																								?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 5%) Alpha helix ( 38%) Beta strand ( 26%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 1rxx chain A Region: 3 - 402 Aligned: 395 Modelled: 400 Confidence: 100.0% Identity: 39% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Arginine deiminase Phyre2 PDB 4bof chain A Region: 3 - 402 Aligned: 399 Modelled: 400 Confidence: 100.0% Identity: 38% PDB header:hydrolase Chain: A: PDB Molecule:arginine deiminase; PDBTitle: crystal structure of arginine deiminase from group a streptococcus Phyre2 PDB 1s9r chain A Region: 4 - 402 Aligned: 387 Modelled: 399 Confidence: 100.0% Identity: 30% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Arginine deiminase Phyre2 PDB 4e4j chain J Region: 5 - 402 Aligned: 386 Modelled: 386 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: J: PDB Molecule:arginine deiminase; PDBTitle: crystal structure of arginine deiminase from mycoplasma penetrans Phyre2 PDB 5wpi chain B Region: 3 - 400 Aligned: 300 Modelled: 304 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:hsva; PDBTitle: the virulence-associated protein hsva from the fire blight pathogen2 erwinia amylovora is a polyamine amidinotransferase Phyre2 PDB 1bwd chain A Region: 3 - 400 Aligned: 305 Modelled: 312 Confidence: 100.0% Identity: 18% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Amidinotransferase Phyre2 PDB 8jdw chain A Region: 5 - 400 Aligned: 303 Modelled: 307 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:protein (l-arginine:glycine amidinotransferase); PDBTitle: crystal structure of human l-arginine:glycine amidinotransferase in2 complex with l-alanine Phyre2 PDB 1jdw chain A Region: 5 - 400 Aligned: 303 Modelled: 308 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:l-arginine\:glycine amidinotransferase; PDBTitle: crystal structure and mechanism of l-arginine: glycine2 amidinotransferase: a mitochondrial enzyme involved in3 creatine biosynthesis Phyre2 PDB 1jdw chain A Region: 5 - 400 Aligned: 303 Modelled: 308 Confidence: 100.0% Identity: 17% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Amidinotransferase Phyre2 PDB 3i4a chain A Region: 9 - 400 Aligned: 266 Modelled: 289 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:n(g),n(g)-dimethylarginine dimethylaminohydrolase 1; PDBTitle: crystal structure of dimethylarginine dimethylaminohydrolase-1 (ddah-2 1) in complex with n5-(1-iminopropyl)-l-ornithine Phyre2 PDB 2ci6 chain A Region: 11 - 399 Aligned: 267 Modelled: 285 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:ng, ng-dimethylarginine dimethylaminohydrolase 1; PDBTitle: crystal structure of dimethylarginine2 dimethylaminohydrolase i bound with zinc low ph Phyre2 PDB 1h70 chain A Region: 13 - 395 Aligned: 252 Modelled: 267 Confidence: 100.0% Identity: 23% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Dimethylarginine dimethylaminohydrolase DDAH Phyre2 PDB 6b2w chain B Region: 10 - 397 Aligned: 284 Modelled: 295 Confidence: 99.6% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:putative peptidyl-arginine deiminase family protein; PDBTitle: c. jejuni c315s agmatine deiminase with substrate bound Phyre2 PDB 2ewo chain A domain 1 Region: 10 - 397 Aligned: 297 Modelled: 314 Confidence: 99.6% Identity: 18% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Porphyromonas-type peptidylarginine deiminase Phyre2 PDB 1xkn chain A Region: 10 - 397 Aligned: 300 Modelled: 317 Confidence: 99.6% Identity: 19% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Porphyromonas-type peptidylarginine deiminase Phyre2 PDB 1zbr chain A domain 1 Region: 10 - 397 Aligned: 304 Modelled: 323 Confidence: 99.5% Identity: 19% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Porphyromonas-type peptidylarginine deiminase Phyre2 PDB 2jer chain G Region: 10 - 397 Aligned: 290 Modelled: 310 Confidence: 99.5% Identity: 21% PDB header:hydrolase Chain: G: PDB Molecule:agmatine deiminase; PDBTitle: agmatine deiminase of enterococcus faecalis catalyzing its2 reaction. Phyre2 PDB 2jer chain A domain 1 Region: 10 - 397 Aligned: 288 Modelled: 311 Confidence: 99.5% Identity: 19% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Porphyromonas-type peptidylarginine deiminase Phyre2 PDB 1vkp chain A Region: 10 - 397 Aligned: 288 Modelled: 311 Confidence: 99.5% Identity: 18% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Porphyromonas-type peptidylarginine deiminase Phyre2 PDB 2cmu chain A domain 1 Region: 10 - 397 Aligned: 291 Modelled: 308 Confidence: 99.5% Identity: 14% Fold: Pentein, beta/alpha-propeller Superfamily: Pentein Family: Porphyromonas-type peptidylarginine deiminase Phyre2 1 d1rxxa_ 2 c4bofA_ 3 d1s9ra_ 4 c4e4jJ_ 5 c5wpiB_ 6 d1bwda_ 7 c8jdwA_ 8 c1jdwA_ 9 d1jdwa_ 10 c3i4aA_ 11 c2ci6A_ 12 d1h70a_ 13 c6b2wB_ 14 d2ewoa1 15 d1xkna_ 16 d1zbra1 17 c2jerG_ 18 d2jera1 19 d1vkpa_ 20 d2cmua1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99