1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	P	V	V	S	P	G	P	L	V	P	V	A	D	F	G	P	L	D	R	L	R	G	W	I	V	T	G	L	I	T	L	L	A	T	V	T	R	F	L	N	L	G	S	L	T	D	A	G	T	P	I	F	D	E	K	H	Y	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	Q	A	W	Q	V	L	N	N	H	G	V	E	D	N	P	G	Y	G	L	V	V	H	P	P	V	G	K	Q	L	I	A	I	G	E	A	I	F	G	Y	N	G	F	G	W	R	F	T	G	A	L	L	G	V	V	L	V	A	L	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	R	I	V	R	R	I	S	R	S	T	L	V	G	A	I	A	G	V	L	L	I	C	D	G	V	S	F	V	T	A	R	T	A	L	L	D	G	F	L	T	F	F	V	V	A	A	F	G	A	L	I	V	D	R	D	Q	V	R	E
Secondary structure
SS confidence
Disorder																																																									?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	M	H	I	A	L	L	A	G	R	S	A	A	T	V	W	G	P	R	V	G	V	R	W	W	R	F	G	A	G	V	L	L	G	L	A	C	A	T	K	W	S	G	V	Y	F	V	L	F	F	G	A	M	A	L	A	F	D	V	A
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	R	R	Q	Y	Q	V	Q	R	P	W	L	G	T	V	R	R	D	V	L	P	S	G	Y	A	L	G	L	I	P	F	A	V	Y	L	A	T	Y	A	P	W	F	A	S	E	T	A	I	D	R	H	A	V	G	Q	A	V	G	R	N
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?																																															?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	V	V	P	L	P	D	A	V	R	S	L	W	H	Y	T	A	K	A	F	H	F	H	A	G	L	T	N	S	A	G	N	Y	H	P	W	E	S	K	P	W	T	W	P	M	S	L	R	P	V	L	Y	A	I	D	Q	Q	D	V	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																		?		?				?		?	?																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	C	G	A	Q	S	C	V	K	A	E	M	L	V	G	T	P	A	M	W	W	L	A	V	P	V	L	A	Y	A	G	W	R	M	F	V	R	R	D	W	R	Y	A	V	V	L	V	G	Y	C	A	G	W	L	P	W	F	A	D	I
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		D	R	Q	M	Y	F	F	Y	A	A	T	M	A	P	F	L	V	M	G	I	S	L	V	L	G	D	I	L	Y	H	P	G	Q	G	S	E	R	R	T	L	G	L	I	V	V	C	C	Y	V	A	L	V	V	T	N	F	A	W	L	Y
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.
Sequence		P	V	L	T	G	L	P	I	S	Q	Q	T	W	N	L	E	I	W	L	P	S	W	R
Secondary structure
SS confidence
Disorder																					?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 69%) Beta strand ( 1%) TM helix ( 48%) (View membrane topology prediction)

Rank Aligned region

PDB 6p25 chain A Region: 1 - 503 Aligned: 458 Modelled: 484 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 1; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor and a peptide acceptor Phyre2 PDB 6p2r chain B Region: 21 - 503 Aligned: 444 Modelled: 464 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 2; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor Phyre2 PDB 5f15 chain A Region: 27 - 474 Aligned: 351 Modelled: 356 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:4-amino-4-deoxy-l-arabinose (l-ara4n) transferase; PDBTitle: crystal structure of arnt from cupriavidus metallidurans bound to2 undecaprenyl phosphate Phyre2 PDB 3rce chain A Region: 19 - 501 Aligned: 406 Modelled: 414 Confidence: 99.8% Identity: 10% PDB header:transferase/peptide Chain: A: PDB Molecule:oligosaccharide transferase to n-glycosylate proteins; PDBTitle: bacterial oligosaccharyltransferase pglb Phyre2 PDB 3waj chain A Region: 28 - 501 Aligned: 417 Modelled: 441 Confidence: 99.8% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:transmembrane oligosaccharyl transferase; PDBTitle: crystal structure of the archaeoglobus fulgidus2 oligosaccharyltransferase (o29867_arcfu) complex with zn and sulfate Phyre2 PDB 6ezn chain F Region: 26 - 501 Aligned: 372 Modelled: 379 Confidence: 99.5% Identity: 11% PDB header:membrane protein Chain: F: PDB Molecule:dolichyl-diphosphooligosaccharide--protein PDBTitle: cryo-em structure of the yeast oligosaccharyltransferase (ost) complex Phyre2 PDB 5ir6 chain B Region: 399 - 502 Aligned: 102 Modelled: 104 Confidence: 19.5% Identity: 8% PDB header:oxidoreductase Chain: B: PDB Molecule:bd-type quinol oxidase subunit ii; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 5nf8 chain A Region: 431 - 479 Aligned: 49 Modelled: 49 Confidence: 16.2% Identity: 6% PDB header:membrane protein Chain: A: PDB Molecule:respiratory supercomplex factor 1, mitochondrial; PDBTitle: solution structure of detergent-solubilized rcf1, a yeast2 mitochondrial inner membrane protein involved in respiratory complex3 iii/iv supercomplex formation Phyre2 PDB 5i6c chain B Region: 76 - 151 Aligned: 66 Modelled: 76 Confidence: 13.4% Identity: 23% PDB header:transport protein Chain: B: PDB Molecule:uric acid-xanthine permease; PDBTitle: the structure of the eukaryotic purine/h+ symporter, uapa, in complex2 with xanthine Phyre2 PDB 1t33 chain A domain 2 Region: 85 - 127 Aligned: 43 Modelled: 43 Confidence: 13.3% Identity: 16% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 1h5o chain A Region: 10 - 25 Aligned: 16 Modelled: 16 Confidence: 10.9% Identity: 44% Fold: Defensin-like Superfamily: Defensin-like Family: Myotoxin Phyre2 PDB 1z99 chain A Region: 10 - 25 Aligned: 16 Modelled: 16 Confidence: 10.9% Identity: 44% PDB header:toxin Chain: A: PDB Molecule:crotamine; PDBTitle: solution structure of crotamine, a myotoxin from crotalus2 durissus terrificus Phyre2 PDB 3b6e chain A Region: 52 - 68 Aligned: 17 Modelled: 17 Confidence: 10.6% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:interferon-induced helicase c domain-containing protein 1; PDBTitle: crystal structure of human dech-box rna helicase mda5 (melanoma2 differentiation-associated protein 5), dech-domain Phyre2 PDB 3hfx chain A Region: 126 - 181 Aligned: 56 Modelled: 56 Confidence: 10.3% Identity: 29% PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter Phyre2 PDB 2l34 chain B Region: 149 - 173 Aligned: 25 Modelled: 25 Confidence: 9.4% Identity: 28% PDB header:protein binding Chain: B: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: structure of the dap12 transmembrane homodimer Phyre2 PDB 4wol chain A Region: 149 - 173 Aligned: 25 Modelled: 25 Confidence: 9.4% Identity: 28% PDB header:signaling protein Chain: A: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipidic cubic2 phase Phyre2 PDB 1yks chain A domain 1 Region: 52 - 69 Aligned: 18 Modelled: 18 Confidence: 9.2% Identity: 28% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: RNA helicase Phyre2 PDB 4wol chain B Region: 149 - 173 Aligned: 25 Modelled: 25 Confidence: 9.2% Identity: 28% PDB header:signaling protein Chain: B: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipidic cubic2 phase Phyre2 PDB 4wol chain C Region: 149 - 173 Aligned: 25 Modelled: 25 Confidence: 9.2% Identity: 28% PDB header:signaling protein Chain: C: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipidic cubic2 phase Phyre2 PDB 4wo1 chain B Region: 149 - 173 Aligned: 25 Modelled: 25 Confidence: 9.2% Identity: 28% PDB header:signaling protein Chain: B: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipid cubic2 phase Phyre2 1 c6p25A_ 2 c6p2rB_ 3 c5f15A_ 4 c3rceA_ 5 c3wajA_ 6 c6eznF_ 7 c5ir6B_ 8 c5nf8A_ 9 c5i6cB_ 10 d1t33a2 11 d1h5oa_ 12 c1z99A_ 13 c3b6eA_ 14 c3hfxA_ 15 c2l34B_ 16 c4wolA_ 17 d1yksa1 18 c4wolB_ 19 c4wolC_ 20 c4wo1B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86