1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	N	L	A	W	E	L	S	T	R	T	K	S	P	R	S	H	L	R	C	E	N	P	Q	F	C	Q	A	R	T	V	R	I	D	R	L	G	D	L	G	G	A	P	A	V	L	R	A	V	G	R	A	T	S	R	L	D	L	P	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?				?		?	?								?																	?	?	?	?	?	?	?	?	?	?	?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	A	A	L	T	G	E	W	F	G	A	L	A	V	I	A	P	S	V	S	I	Q	P	V	S	G	D	D	V	F	S	G	P	P	G	T	G	G	P	D	A	T	G	A	V	G	G	G	W	V	G	Y	L	S	Y	P	D	A	G	A
Secondary structure
SS confidence
Disorder			?					?											?			?	?												?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	G	R	P	H	R	I	P	E	A	A	G	G	W	T	D	C	V	L	R	R	D	R	D	G	Q	W	W	Y	E	S	L	S	G	A	P	I	A	D	W	L	A	S	A	L	A	T	T	R	A	S	V	A	R	P	A	P	A	C	R
Secondary structure
SS confidence
Disorder																																																	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	D	W	E	P	A	D	R	A	A	H	R	D	G	V	L	A	C	L	E	A	I	G	A	G	E	V	Y	Q	A	C	V	C	T	Q	F	A	G	T	V	T	G	S	P	L	D	F	F	I	D	G	F	G	R	T	A	P	S	R	S
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	F	V	A	G	P	W	G	A	V	A	S	L	S	P	E	L	F	L	R	R	R	G	S	V	V	T	S	S	P	I	K	G	T	L	P	L	D	A	P	P	S	A	L	R	A	S	A	K	E	V	A	E	N	I	M	I	V	D	L
Secondary structure
SS confidence
Disorder																																														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	R	N	D	L	G	R	V	A	V	T	G	T	V	T	V	P	E	L	L	V	V	R	P	A	P	G	V	W	H	L	V	S	T	V	S	A	R	V	P	L	E	E	P	M	S	A	L	L	D	A	A	F	P	P	A	S	V	T	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		T	P	K	L	R	A	R	Q	L	I	S	Q	W	E	R	Y	R	R	G	I	Y	C	G	T	V	G	L	A	S	P	V	A	G	C	E	L	N	V	A	I	R	T	V	E	F	D	T	A	G	N	A	V	L	G	V	G	G	G	I	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.
Sequence		A	D	S	D	P	D	A	E	W	A	E	C	L	H	K	A	A	P	I	V	G	L	P	A	A	T	R	T	T	P	A	R	L	A	S	K	V	R
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 27%) Beta strand ( 29%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 4pen chain A Region: 42 - 454 Aligned: 411 Modelled: 413 Confidence: 100.0% Identity: 27% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component 1; PDBTitle: structure of anthranilate synthase component i (trpe) from2 mycobacterium tuberculosis with inhibitor bound Phyre2 PDB 1i7q chain A Region: 26 - 444 Aligned: 416 Modelled: 419 Confidence: 100.0% Identity: 24% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1i1q chain A Region: 104 - 444 Aligned: 338 Modelled: 341 Confidence: 100.0% Identity: 25% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1qdl chain A Region: 65 - 446 Aligned: 367 Modelled: 371 Confidence: 100.0% Identity: 28% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 5kck chain A Region: 42 - 440 Aligned: 394 Modelled: 397 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i; PDBTitle: crystal structure of anthranilate synthase component i from2 streptococcus pneumoniae tigr4 Phyre2 PDB 4grh chain A Region: 99 - 444 Aligned: 337 Modelled: 346 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:aminodeoxychorismate synthase; PDBTitle: crystal structure of pabb of stenotrophomonas maltophilia Phyre2 PDB 2g5f chain A domain 1 Region: 104 - 443 Aligned: 332 Modelled: 340 Confidence: 100.0% Identity: 22% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1k0g chain A Region: 55 - 444 Aligned: 360 Modelled: 373 Confidence: 100.0% Identity: 29% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 2i6y chain A Region: 104 - 443 Aligned: 325 Modelled: 336 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i, putative; PDBTitle: structure and mechanism of mycobacterium tuberculosis salicylate2 synthase, mbti Phyre2 PDB 2fn0 chain A domain 1 Region: 100 - 443 Aligned: 315 Modelled: 318 Confidence: 100.0% Identity: 24% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3h9m chain A Region: 105 - 444 Aligned: 314 Modelled: 340 Confidence: 100.0% Identity: 27% PDB header:lyase Chain: A: PDB Molecule:p-aminobenzoate synthetase, component i; PDBTitle: crystal structure of para-aminobenzoate synthetase, component i from2 cytophaga hutchinsonii Phyre2 PDB 3os6 chain A Region: 170 - 445 Aligned: 272 Modelled: 275 Confidence: 100.0% Identity: 24% PDB header:isomerase Chain: A: PDB Molecule:isochorismate synthase dhbc; PDBTitle: crystal structure of putative 2,3-dihydroxybenzoate-specific2 isochorismate synthase, dhbc from bacillus anthracis. Phyre2 PDB 3r74 chain B Region: 99 - 451 Aligned: 345 Modelled: 350 Confidence: 100.0% Identity: 22% PDB header:lyase, biosynthetic protein Chain: B: PDB Molecule:anthranilate/para-aminobenzoate synthases component i; PDBTitle: crystal structure of 2-amino-2-desoxyisochorismate synthase (adic)2 synthase phze from burkholderia lata 383 Phyre2 PDB 3hwo chain B Region: 143 - 444 Aligned: 298 Modelled: 302 Confidence: 100.0% Identity: 20% PDB header:isomerase Chain: B: PDB Molecule:isochorismate synthase entc; PDBTitle: crystal structure of escherichia coli enterobactin-specific2 isochorismate synthase entc in complex with isochorismate Phyre2 PDB 3bzn chain A domain 1 Region: 109 - 443 Aligned: 318 Modelled: 333 Confidence: 100.0% Identity: 23% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3gse chain A Region: 109 - 439 Aligned: 316 Modelled: 331 Confidence: 100.0% Identity: 22% PDB header:isomerase Chain: A: PDB Molecule:menaquinone-specific isochorismate synthase; PDBTitle: crystal structure of menaquinone-specific isochorismate synthase from2 yersinia pestis co92 Phyre2 PDB 3nqk chain A Region: 379 - 416 Aligned: 38 Modelled: 38 Confidence: 26.5% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a structural genomics, unknown function2 (bacova_03322) from bacteroides ovatus at 2.61 a resolution Phyre2 PDB 1cvr chain A domain 1 Region: 381 - 423 Aligned: 37 Modelled: 43 Confidence: 24.0% Identity: 19% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Gingipain R (RgpB), C-terminal domain Phyre2 PDB 1rp3 chain B Region: 191 - 211 Aligned: 20 Modelled: 21 Confidence: 19.3% Identity: 30% Fold: Non-globular all-alpha subunits of globular proteins Superfamily: Anti-sigma factor FlgM Family: Anti-sigma factor FlgM Phyre2 PDB 4k6n chain A Region: 375 - 435 Aligned: 60 Modelled: 61 Confidence: 19.1% Identity: 8% PDB header:lyase Chain: A: PDB Molecule:aminodeoxychorismate lyase; PDBTitle: crystal structure of yeast 4-amino-4-deoxychorismate lyase Phyre2 1 c4penA_ 2 d1i7qa_ 3 d1i1qa_ 4 d1qdla_ 5 c5kckA_ 6 c4grhA_ 7 d2g5fa1 8 d1k0ga_ 9 c2i6yA_ 10 d2fn0a1 11 c3h9mA_ 12 c3os6A_ 13 c3r74B_ 14 c3hwoB_ 15 d3bzna1 16 c3gseA_ 17 c3nqkA_ 18 d1cvra1 19 d1rp3b_ 20 c4k6nA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64