1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	P	T	G	S	V	T	V	R	V	P	G	K	V	N	L	Y	L	A	V	G	D	R	R	E	D	G	Y	H	E	L	T	T	V	F	H	A	V	S	L	V	D	E	V	T	V	R	N	A	D	V	L	S	L	E	L	V	G	E	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	D	Q	L	P	T	D	E	R	N	L	A	W	Q	A	A	E	L	M	A	E	H	V	G	R	A	P	D	V	S	I	M	I	D	K	S	I	P	V	A	G	G	M	A	G	G	S	A	D	A	A	A	V	L	V	A	M	N	S	L
Secondary structure
SS confidence
Disorder																																									?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	E	L	N	V	P	R	R	D	L	R	M	L	A	A	R	L	G	S	D	V	P	F	A	L	H	G	G	T	A	L	G	T	G	R	G	E	E	L	A	T	V	L	S	R	N	T	F	H	W	V	L	A	F	A	D	S	G	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	S	A	V	Y	N	E	L	D	R	L	R	E	V	G	D	P	P	R	L	G	E	P	G	P	V	L	A	A	L	A	A	G	D	P	D	Q	L	A	P	L	L	G	N	E	M	Q	A	A	A	V	S	L	D	P	A	L	A	R	A
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	R	A	G	V	E	A	G	A	L	A	G	I	V	S	G	S	G	P	T	C	A	F	L	C	T	S	A	S	S	A	I	D	V	G	A	Q	L	S	G	A	G	V	C	R	T	V	R	V	A	T	G	P	V	P	G	A	R	V	V
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.
Sequence		S	A	P	T	E	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 34%) Beta strand ( 27%)

Rank Aligned region

PDB 3pyg chain A Region: 4 - 301 Aligned: 298 Modelled: 298 Confidence: 100.0% Identity: 100% PDB header:transferase Chain: A: PDB Molecule:4-diphosphocytidyl-2-c-methyl-d-erythritol kinase; PDBTitle: mycobacterium tuberculosis 4-diphosphocytidyl-2-c-methyl-d-erythritol2 kinase (ispe) in complex with adp Phyre2 PDB 1uek chain A Region: 6 - 292 Aligned: 268 Modelled: 287 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:4-(cytidine 5'-diphospho)-2c-methyl-d-erythritol PDBTitle: crystal structure of 4-(cytidine 5'-diphospho)-2c-methyl-d-2 erythritol kinase Phyre2 PDB 2v34 chain B Region: 3 - 277 Aligned: 260 Modelled: 275 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: B: PDB Molecule:4-diphosphocytidyl-2c-methyl-d-erythritol kinase; PDBTitle: ispe in complex with cytidine and ligand Phyre2 PDB 1oj4 chain B Region: 4 - 291 Aligned: 268 Modelled: 272 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: B: PDB Molecule:4-diphosphocytidyl-2-c-methyl-d-erythritol PDBTitle: ternary complex of2 4-diphosphocytidyl-2-c-methyl-d-erythritol kinase Phyre2 PDB 4rpf chain A Region: 4 - 300 Aligned: 289 Modelled: 289 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:homoserine kinase; PDBTitle: crystal structure of homoserine kinase from yersinia pestis nepal516,2 nysgrc target 032715 Phyre2 PDB 4p52 chain A Region: 5 - 300 Aligned: 285 Modelled: 288 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:homoserine kinase; PDBTitle: crystal structure of homoserine kinase from cytophaga hutchinsonii2 atcc 33406, nysgrc target 032717. Phyre2 PDB 1fwl chain D Region: 4 - 300 Aligned: 281 Modelled: 289 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: D: PDB Molecule:homoserine kinase; PDBTitle: crystal structure of homoserine kinase Phyre2 PDB 6cyz chain A Region: 4 - 299 Aligned: 273 Modelled: 287 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:homoserine kinase; PDBTitle: mycobacterial homoserine kinase thrb in complex with amppnp Phyre2 PDB 3hul chain A Region: 5 - 302 Aligned: 272 Modelled: 293 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:homoserine kinase; PDBTitle: structure of putative homoserine kinase thrb from listeria2 monocytogenes Phyre2 PDB 2cz9 chain A Region: 5 - 299 Aligned: 288 Modelled: 295 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:probable galactokinase; PDBTitle: crystal structure of galactokinase from pyrococcus horikoshi Phyre2 PDB 5wat chain B Region: 5 - 301 Aligned: 278 Modelled: 286 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:homoserine kinase; PDBTitle: corynebacterium glutamicum full length homoserine kinase Phyre2 PDB 4z7c chain A Region: 5 - 302 Aligned: 291 Modelled: 298 Confidence: 100.0% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:diphosphomevalonate decarboxylase; PDBTitle: diphosphomevalonate decarboxylase from the sulfolobus solfataricus,2 space group h32 Phyre2 PDB 4hac chain A Region: 3 - 299 Aligned: 282 Modelled: 293 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:mevalonate kinase; PDBTitle: crystal structure of the mevalonate kinase from an archaeon2 methanosarcina mazei Phyre2 PDB 2hk3 chain A Region: 5 - 301 Aligned: 295 Modelled: 296 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:diphosphomevalonate decarboxylase; PDBTitle: crystal structure of mevalonate diphosphate decarboxylase2 from staphylococcus aureus (orthorhombic form) Phyre2 PDB 2hfu chain B Region: 9 - 297 Aligned: 284 Modelled: 285 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:mevalonate kinase, putative; PDBTitle: crystal structure of l. major mevalonate kinase in complex2 with r-mevalonate Phyre2 PDB 5v2l chain A Region: 5 - 302 Aligned: 295 Modelled: 298 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:mevalonate diphosphate decarboxylase; PDBTitle: mevalonate diphosphate mediated atp binding mechanism of the2 mevalonate diphosphate decarboxylase from enterococcus faecalis Phyre2 PDB 2x7i chain A Region: 3 - 289 Aligned: 276 Modelled: 287 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:mevalonate kinase; PDBTitle: crystal structure of mevalonate kinase from methicillin-2 resistant staphylococcus aureus mrsa252 Phyre2 PDB 4ut4 chain B Region: 4 - 299 Aligned: 289 Modelled: 292 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:putative sugar kinase; PDBTitle: burkholderia pseudomallei heptokinase wcbl, d-mannose complex. Phyre2 PDB 1pie chain A Region: 1 - 300 Aligned: 292 Modelled: 296 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:galactokinase; PDBTitle: crystal structure of lactococcus lactis galactokinase2 complexed with galactose Phyre2 PDB 2a2c chain A Region: 3 - 300 Aligned: 292 Modelled: 298 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:n-acetylgalactosamine kinase; PDBTitle: x-ray structure of human n-acetyl galactosamine kinase2 complexed with mg-adp and n-acetyl galactosamine 1-3 phosphate Phyre2 1 c3pygA_ 2 c1uekA_ 3 c2v34B_ 4 c1oj4B_ 5 c4rpfA_ 6 c4p52A_ 7 c1fwlD_ 8 c6cyzA_ 9 c3hulA_ 10 c2cz9A_ 11 c5watB_ 12 c4z7cA_ 13 c4hacA_ 14 c2hk3A_ 15 c2hfuB_ 16 c5v2lA_ 17 c2x7iA_ 18 c4ut4B_ 19 c1pieA_ 20 c2a2cA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99