1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	Q	Q	G	N	P	P	D	A	P	Q	L	A	P	A	V	A	W	V	K	K	R	A	G	R	T	P	R	T	V	T	A	D	R	G	Y	G	E	A	A	V	D	Q	Q	L	T	E	V	G	V	K	N	V	L	I	P	R	K	G	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																															?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	S	Q	D	R	R	A	E	E	H	R	K	A	F	R	R	T	I	K	W	R	T	G	C	E	G	R	I	S	H	L	K	R	G	Y	G	W	D	R	G	R	I	G	G	L	E	G	T	R	T	W	V	G	H	G	V	F	A	H	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		L	V	T	I	S	A	L	P	A
Secondary structure
SS confidence
Disorder									?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 67%) Beta strand ( 4%) TM helix ( 12%) (View membrane topology prediction)

Rank Aligned region

PDB 1mus chain A Region: 8 - 118 Aligned: 111 Modelled: 111 Confidence: 97.5% Identity: 23% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Transposase inhibitor (Tn5 transposase) Phyre2 PDB 1b7e chain A Region: 13 - 127 Aligned: 114 Modelled: 115 Confidence: 97.5% Identity: 20% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Transposase inhibitor (Tn5 transposase) Phyre2 PDB 1cxq chain A Region: 8 - 120 Aligned: 89 Modelled: 91 Confidence: 75.0% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 1asu chain A Region: 8 - 120 Aligned: 93 Modelled: 95 Confidence: 70.6% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 2b5d chain X Region: 11 - 54 Aligned: 44 Modelled: 44 Confidence: 52.9% Identity: 18% PDB header:hydrolase Chain: X: PDB Molecule:alpha-amylase; PDBTitle: crystal structure of the novel alpha-amylase amyc from thermotoga2 maritima Phyre2 PDB 2etj chain A Region: 34 - 98 Aligned: 61 Modelled: 65 Confidence: 50.7% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease hii; PDBTitle: crystal structure of ribonuclease hii (ec 3.1.26.4) (rnase hii)2 (tm0915) from thermotoga maritima at 1.74 a resolution Phyre2 PDB 2etj chain A domain 1 Region: 34 - 98 Aligned: 61 Modelled: 65 Confidence: 50.7% Identity: 13% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Ribonuclease H Phyre2 PDB 5cz1 chain B Region: 8 - 120 Aligned: 91 Modelled: 95 Confidence: 49.8% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of the catalytic core domain of mmtv integrase Phyre2 PDB 2b5d chain X domain 2 Region: 11 - 54 Aligned: 44 Modelled: 44 Confidence: 40.2% Identity: 18% Fold: 7-stranded beta/alpha barrel Superfamily: Glycoside hydrolase/deacetylase Family: AmyC N-terminal domain-like Phyre2 PDB 3nf9 chain A Region: 8 - 120 Aligned: 90 Modelled: 95 Confidence: 25.6% Identity: 21% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:integrase; PDBTitle: structural basis for a new mechanism of inhibition of hiv integrase2 identified by fragment screening and structure based design Phyre2 PDB 5my5 chain A Region: 1 - 35 Aligned: 35 Modelled: 35 Confidence: 22.9% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:abc transporter periplasmic substrate-binding protein; PDBTitle: tungstate binding protein - tupa - from desulfovibrio alaskensis g20 Phyre2 PDB 1ufa chain A domain 2 Region: 4 - 54 Aligned: 51 Modelled: 51 Confidence: 22.9% Identity: 24% Fold: 7-stranded beta/alpha barrel Superfamily: Glycoside hydrolase/deacetylase Family: AmyC N-terminal domain-like Phyre2 PDB 2qsr chain A Region: 4 - 30 Aligned: 27 Modelled: 27 Confidence: 20.5% Identity: 15% PDB header:transcription Chain: A: PDB Molecule:transcription-repair coupling factor; PDBTitle: crystal structure of c-terminal domain of transcription-repair2 coupling factor Phyre2 PDB 4mq3 chain A Region: 8 - 120 Aligned: 90 Modelled: 95 Confidence: 19.7% Identity: 17% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: the 1.1 angstrom structure of catalytic core domain of fiv integrase Phyre2 PDB 1k6y chain B Region: 8 - 120 Aligned: 81 Modelled: 86 Confidence: 18.0% Identity: 25% PDB header:transferase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of a two-domain fragment of hiv-1 integrase Phyre2 PDB 3tsm chain B Region: 5 - 55 Aligned: 51 Modelled: 51 Confidence: 16.4% Identity: 18% PDB header:lyase Chain: B: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of indole-3-glycerol phosphate synthase from2 brucella melitensis Phyre2 PDB 1c6v chain A Region: 8 - 120 Aligned: 79 Modelled: 84 Confidence: 16.2% Identity: 22% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 4zya chain A Region: 2 - 37 Aligned: 35 Modelled: 36 Confidence: 15.2% Identity: 14% PDB header:ligase Chain: A: PDB Molecule:asparagine--trna ligase, cytoplasmic; PDBTitle: the n-terminal extension domain of human asparaginyl-trna synthetase Phyre2 PDB 2wcv chain I Region: 9 - 36 Aligned: 28 Modelled: 28 Confidence: 14.3% Identity: 18% PDB header:isomerase Chain: I: PDB Molecule:l-fucose mutarotase; PDBTitle: crystal structure of bacterial fucu Phyre2 PDB 3jca chain E Region: 8 - 120 Aligned: 93 Modelled: 95 Confidence: 13.5% Identity: 15% PDB header:viral protein Chain: E: PDB Molecule:integrase; PDBTitle: core model of the mouse mammary tumor virus intasome Phyre2 1 d1musa_ 2 d1b7ea_ 3 d1cxqa_ 4 d1asua_ 5 c2b5dX_ 6 c2etjA_ 7 d2etja1 8 c5cz1B_ 9 d2b5dx2 10 c3nf9A_ 11 c5my5A_ 12 d1ufaa2 13 c2qsrA_ 14 c4mq3A_ 15 c1k6yB_ 16 c3tsmB_ 17 d1c6va_ 18 c4zyaA_ 19 c2wcvI_ 20 c3jcaE_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61