1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	A	S	P	A	D	G	L	A	I	T	G	L	S	W	K	G	S	R	G	G	S	V	R	E	V	R	G	G	T	C	P	L	S	S	G	R	G	K	R	C	G	S	A	I	T	V	G	R	W	M	V	P	A	T	R	C	S	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?										?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	L	P	R	C	S	G	W	T	L	R	W	P	R	I	S	R	S	C	C	R	W	I	P	R	T	C	G	H	T	S	I	R	R	A	P	A	R	T	R	S	P	Q	G	A	L	S	D	Y	K	K	S	A	D	E	P	D	D	H	A
Secondary structure
SS confidence
Disorder																															?				?		?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	G	R	S	R	G	G	L	T	T	K	I	H	A	L	T	D	Q	R	E	A	P	V	R	I	R	L	T	A	G	Q	A	G	D	N	P	Q	L	L	P	L	L	D	D	Y	R	H	A	S	T	E	Y	A	L	G	S	T	D	F	R
Secondary structure
SS confidence
Disorder					?																												?															?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	L	A	D	K	A	Y	S	H	P	S	T	R	A	A	L	R	S	K	K	I	K	H	T	I	P	E	R	Q	D	Q	I	D	R	R	K	A	K	G	S	A	G	G	R	P	P	A	F	D	A	A	L	Y	G	L	R	N	T	V	E
Secondary structure
SS confidence
Disorder																																	?		?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.
Sequence		R	G	F	H	R	L	K	Q	W	R	G	I	A	T	R	Y	D	K	Y	A	L	T	Y	L	G	G	V	L	L	A	C	A	V	I	H	A	R	V	G	T	P	K	L	G	D	T	P
Secondary structure
SS confidence
Disorder																																							?		?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 33%) Beta strand ( 10%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 1mus chain A Region: 108 - 275 Aligned: 168 Modelled: 168 Confidence: 97.7% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Transposase inhibitor (Tn5 transposase) Phyre2 PDB 1b7e chain A Region: 134 - 275 Aligned: 140 Modelled: 142 Confidence: 97.4% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Transposase inhibitor (Tn5 transposase) Phyre2 PDB 3hos chain A Region: 109 - 267 Aligned: 135 Modelled: 136 Confidence: 94.0% Identity: 13% PDB header:transferase, dna binding protein/dna Chain: A: PDB Molecule:transposable element mariner, complete cds; PDBTitle: crystal structure of the mariner mos1 paired end complex with mg Phyre2 PDB 1asu chain A Region: 132 - 287 Aligned: 126 Modelled: 134 Confidence: 78.2% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 1cxq chain A Region: 124 - 248 Aligned: 90 Modelled: 99 Confidence: 73.5% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 4mq3 chain A Region: 132 - 277 Aligned: 112 Modelled: 124 Confidence: 32.8% Identity: 15% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: the 1.1 angstrom structure of catalytic core domain of fiv integrase Phyre2 PDB 1c0m chain A Region: 132 - 287 Aligned: 126 Modelled: 134 Confidence: 28.9% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:protein (integrase); PDBTitle: crystal structure of rsv two-domain integrase Phyre2 PDB 3k2k chain A Region: 121 - 206 Aligned: 73 Modelled: 86 Confidence: 28.5% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:putative carboxypeptidase; PDBTitle: crystal structure of putative carboxypeptidase (yp_103406.1) from2 burkholderia mallei atcc 23344 at 2.49 a resolution Phyre2 PDB 1a6q chain A domain 1 Region: 232 - 246 Aligned: 15 Modelled: 15 Confidence: 27.9% Identity: 40% Fold: Another 3-helical bundle Superfamily: Protein serine/threonine phosphatase 2C, C-terminal domain Family: Protein serine/threonine phosphatase 2C, C-terminal domain Phyre2 PDB 6mel chain A Region: 121 - 223 Aligned: 97 Modelled: 103 Confidence: 25.6% Identity: 14% PDB header:ligase Chain: A: PDB Molecule:succinate--coa ligase subunit alpha; PDBTitle: succinyl-coa synthase from campylobacter jejuni Phyre2 PDB 2nu7 chain A domain 2 Region: 121 - 211 Aligned: 85 Modelled: 91 Confidence: 25.3% Identity: 14% Fold: Flavodoxin-like Superfamily: Succinyl-CoA synthetase domains Family: Succinyl-CoA synthetase domains Phyre2 PDB 1bco chain A domain 2 Region: 117 - 247 Aligned: 100 Modelled: 114 Confidence: 24.6% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: mu transposase, core domain Phyre2 PDB 1bco chain A Region: 131 - 248 Aligned: 93 Modelled: 99 Confidence: 24.3% Identity: 19% PDB header:transposase Chain: A: PDB Molecule:bacteriophage mu transposase; PDBTitle: bacteriophage mu transposase core domain Phyre2 PDB 1oi7 chain A domain 2 Region: 121 - 205 Aligned: 79 Modelled: 85 Confidence: 23.3% Identity: 22% Fold: Flavodoxin-like Superfamily: Succinyl-CoA synthetase domains Family: Succinyl-CoA synthetase domains Phyre2 PDB 3nf9 chain A Region: 132 - 248 Aligned: 85 Modelled: 95 Confidence: 23.0% Identity: 14% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:integrase; PDBTitle: structural basis for a new mechanism of inhibition of hiv integrase2 identified by fragment screening and structure based design Phyre2 PDB 2csu chain A domain 2 Region: 121 - 198 Aligned: 71 Modelled: 78 Confidence: 22.5% Identity: 14% Fold: Flavodoxin-like Superfamily: Succinyl-CoA synthetase domains Family: Succinyl-CoA synthetase domains Phyre2 PDB 5cr4 chain B Region: 107 - 248 Aligned: 119 Modelled: 127 Confidence: 21.1% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:sleeping beauty transposase, sb100x; PDBTitle: crystal structure of the sleeping beauty transposase catalytic domain Phyre2 PDB 5cz1 chain B Region: 184 - 248 Aligned: 43 Modelled: 43 Confidence: 16.7% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of the catalytic core domain of mmtv integrase Phyre2 PDB 2oxg chain D Region: 131 - 151 Aligned: 21 Modelled: 21 Confidence: 15.6% Identity: 14% PDB header:transport protein Chain: D: PDB Molecule:soxy protein; PDBTitle: the soxyz complex of paracoccus pantotrophus Phyre2 PDB 3mwd chain B Region: 121 - 205 Aligned: 79 Modelled: 85 Confidence: 14.3% Identity: 13% PDB header:transferase Chain: B: PDB Molecule:atp-citrate synthase; PDBTitle: truncated human atp-citrate lyase with citrate bound Phyre2 1 d1musa_ 2 d1b7ea_ 3 c3hosA_ 4 d1asua_ 5 d1cxqa_ 6 c4mq3A_ 7 c1c0mA_ 8 c3k2kA_ 9 d1a6qa1 10 c6melA_ 11 d2nu7a2 12 d1bcoa2 13 c1bcoA_ 14 d1oi7a2 15 c3nf9A_ 16 d2csua2 17 c5cr4B_ 18 c5cz1B_ 19 c2oxgD_ 20 c3mwdB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57