1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	K	P	Y	S	S	P	P	T	N	L	R	S	L	R	D	R	L	T	Q	V	A	E	R	Q	G	V	V	F	G	R	L	Q	R	H	V	A	M	I	V	V	A	Q	F	A	A	T	L	T	D	D	T	G	A	P	L	L	L	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?														?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	G	G	S	S	L	E	L	R	R	G	I	P	D	S	R	T	S	K	D	F	D	T	V	A	R	R	D	I	E	L	I	H	E	Q	L	A	D	A	G	E	T	G	W	E	G	F	T	A	I	F	T	A	P	E	E	I	D	V	P
Secondary structure
SS confidence
Disorder												?	?	?	?																																								?	?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	M	P	V	K	P	R	R	F	T	A	K	L	S	Y	R	G	R	A	F	A	T	V	P	I	E	V	S	S	V	E	A	G	N	A	D	Q	F	D	T	L	T	S	D	A	L	G	L	V	G	V	P	A	A	V	A	V	P	C	M
Secondary structure
SS confidence
Disorder		?																	?		?	?									?	?	?	?			?			?	?			?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	I	P	W	Q	I	A	Q	K	L	H	A	V	T	A	V	L	E	E	P	K	V	N	D	R	A	H	D	L	V	D	L	Q	L	L	E	G	L	L	L	D	A	D	L	M	P	T	R	S	A	C	I	A	I	F	E	A	R	A	Q
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.
Sequence		H	P	W	P	P	R	V	A	T	L	P	H	W	P	L	I	Y	A	G	A	L	E	G	L	D	H	L	E	L	A	R	T	V	D	A	A	A	Q	A	V	Q	R	F	V	A	R	I	D	R	A	T	K	R
Secondary structure
SS confidence
Disorder										?					?									?	?	?	?	?	?	?	?																	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 46%) Beta strand ( 11%)

Rank Aligned region

PDB 4ok0 chain B Region: 38 - 289 Aligned: 214 Modelled: 252 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:putative; PDBTitle: crystal structure of putative nucleotidyltransferase from h. pylori Phyre2 PDB 5uvd chain A Region: 28 - 238 Aligned: 189 Modelled: 201 Confidence: 98.9% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:nucleotidyltransferase-like protein; PDBTitle: crystal structure of an antigenic nucleotidyltransferase-like protein2 from paracoccidioides brasiliensis Phyre2 PDB 4wqk chain A Region: 38 - 237 Aligned: 172 Modelled: 186 Confidence: 98.2% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:2''-aminoglycoside nucleotidyltransferase; PDBTitle: crystal structure of aminoglycoside nucleotidylyltransferase ant(2")-2 ia, apo form Phyre2 PDB 4e8i chain A Region: 42 - 219 Aligned: 150 Modelled: 178 Confidence: 98.1% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:lincosamide resistance protein; PDBTitle: crystal structure of lincosamide antibiotic adenylyltransferase lina,2 apo Phyre2 PDB 1vfg chain B Region: 45 - 128 Aligned: 79 Modelled: 84 Confidence: 85.3% Identity: 19% PDB header:transferase/rna Chain: B: PDB Molecule:poly a polymerase; PDBTitle: crystal structure of trna nucleotidyltransferase complexed2 with a primer trna and an incoming atp analog Phyre2 PDB 1vfg chain A domain 2 Region: 45 - 110 Aligned: 61 Modelled: 66 Confidence: 69.4% Identity: 18% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Poly A polymerase head domain-like Phyre2 PDB 3h37 chain B Region: 44 - 98 Aligned: 50 Modelled: 55 Confidence: 51.2% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:trna nucleotidyl transferase-related protein; PDBTitle: the structure of cca-adding enzyme apo form i Phyre2 PDB 3wfr chain E Region: 44 - 101 Aligned: 55 Modelled: 58 Confidence: 48.8% Identity: 18% PDB header:transferase/rna Chain: E: PDB Molecule:poly a polymerase; PDBTitle: trna processing enzyme complex 2 Phyre2 PDB 4x4w chain B Region: 46 - 99 Aligned: 49 Modelled: 54 Confidence: 44.4% Identity: 20% PDB header:rna binding protein Chain: B: PDB Molecule:cca trna nucleotidyltransferase 1, mitochondrial; PDBTitle: crystal structure of the full-length human mitochondrial cca-adding2 enzyme Phyre2 PDB 3wfp chain A Region: 44 - 143 Aligned: 97 Modelled: 100 Confidence: 41.5% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:poly a polymerase; PDBTitle: trna processing enzyme (apo form 2) Phyre2 PDB 1qb2 chain A Region: 17 - 40 Aligned: 24 Modelled: 24 Confidence: 41.0% Identity: 25% Fold: Signal peptide-binding domain Superfamily: Signal peptide-binding domain Family: Signal peptide-binding domain Phyre2 PDB 1dul chain A Region: 17 - 40 Aligned: 24 Modelled: 24 Confidence: 38.4% Identity: 17% Fold: Signal peptide-binding domain Superfamily: Signal peptide-binding domain Family: Signal peptide-binding domain Phyre2 PDB 3wfs chain D Region: 44 - 143 Aligned: 97 Modelled: 100 Confidence: 37.8% Identity: 11% PDB header:transferase/rna Chain: D: PDB Molecule:poly a polymerase; PDBTitle: trna processing enzyme complex 3 Phyre2 PDB 2jqe chain A Region: 17 - 40 Aligned: 24 Modelled: 24 Confidence: 36.9% Identity: 13% PDB header:signaling protein Chain: A: PDB Molecule:signal recognition 54 kda protein; PDBTitle: soution structure of af54 m-domain Phyre2 PDB 3wfr chain G Region: 44 - 143 Aligned: 97 Modelled: 100 Confidence: 34.9% Identity: 11% PDB header:transferase/rna Chain: G: PDB Molecule:poly a polymerase; PDBTitle: trna processing enzyme complex 2 Phyre2 PDB 3wfq chain G Region: 44 - 101 Aligned: 55 Modelled: 58 Confidence: 34.8% Identity: 18% PDB header:transferase/rna Chain: G: PDB Molecule:poly a polymerase; PDBTitle: trna processing enzyme complex 1 Phyre2 PDB 1hq1 chain A Region: 16 - 40 Aligned: 25 Modelled: 25 Confidence: 34.3% Identity: 16% Fold: Signal peptide-binding domain Superfamily: Signal peptide-binding domain Family: Signal peptide-binding domain Phyre2 PDB 4ue4 chain C Region: 17 - 40 Aligned: 24 Modelled: 24 Confidence: 32.2% Identity: 17% PDB header:translation Chain: C: PDB Molecule:signal recognition particle protein; PDBTitle: structural basis for targeting and elongation arrest of bacillus2 signal recognition particle Phyre2 PDB 2ffh chain A domain 2 Region: 17 - 40 Aligned: 24 Modelled: 24 Confidence: 30.5% Identity: 17% Fold: Signal peptide-binding domain Superfamily: Signal peptide-binding domain Family: Signal peptide-binding domain Phyre2 PDB 1qzx chain A domain 2 Region: 17 - 40 Aligned: 24 Modelled: 24 Confidence: 30.2% Identity: 17% Fold: Signal peptide-binding domain Superfamily: Signal peptide-binding domain Family: Signal peptide-binding domain Phyre2 1 c4ok0B_ 2 c5uvdA_ 3 c4wqkA_ 4 c4e8iA_ 5 c1vfgB_ 6 d1vfga2 7 c3h37B_ 8 c3wfrE_ 9 c4x4wB_ 10 c3wfpA_ 11 d1qb2a_ 12 d1dula_ 13 c3wfsD_ 14 c2jqeA_ 15 c3wfrG_ 16 c3wfqG_ 17 d1hq1a_ 18 c4ue4C_ 19 d2ffha2 20 d1qzxa2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54