1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	I	A	Q	H	I	S	E	L	I	G	G	T	P	L	V	R	L	N	S	V	V	P	D	G	A	G	T	V	A	A	K	V	E	Y	L	N	P	G	G	S	S	K	D	R	I	A	V	K	M	I	E	A	A	E	A	S	G	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?															?	?		?																																		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	K	P	G	G	T	I	V	E	P	T	S	G	N	T	G	V	G	L	A	L	V	A	Q	R	R	G	Y	K	C	V	F	V	C	P	D	K	V	S	E	D	K	R	N	V	L	I	A	Y	G	A	E	V	V	V	C	P	T	A	V
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	P	H	D	P	A	S	Y	Y	S	V	S	D	R	L	V	R	D	I	D	G	A	W	K	P	D	Q	Y	A	N	P	E	G	P	A	S	H	Y	V	T	T	G	P	E	I	W	A	D	T	E	G	K	V	T	H	F	V	A	G	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	T	G	G	T	I	T	G	A	G	R	Y	L	K	E	V	S	G	G	R	V	R	I	V	G	A	D	P	E	G	S	V	Y	S	G	G	A	G	R	P	Y	L	V	E	G	V	G	E	D	F	W	P	A	A	Y	D	P	S	V	P
Secondary structure
SS confidence
Disorder																																				?		?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	E	I	I	A	V	S	D	S	D	S	F	D	M	T	R	R	L	A	R	E	E	A	M	L	V	G	G	S	C	G	M	A	V	V	A	A	L	K	V	A	E	E	A	G	P	D	A	L	I	V	V	L	L	P	D	G	G	R	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	M	S	K	I	F	N	D	A	W	M	S	S	Y	G	F	L	R	S	R	L	D	G	S	T	E	Q	S	T	V	G	D	V	L	R	R	K	S	G	A	L	P	A	L	V	H	T	H	P	S	E	T	V	R	D	A	I	G	I	L
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?	?		?									?	?	?	?	?	?	?					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	E	Y	G	V	S	Q	M	P	V	V	G	A	E	P	P	V	M	A	G	E	V	A	G	S	V	S	E	R	E	L	L	S	A	V	F	E	G	R	A	K	L	A	D	A	V	S	A	H	M	S	P	P	L	R	M	I	G	A	G
Secondary structure
SS confidence
Disorder						?									?	?		?	?	?																		?	?	?	?	?	?	?													?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.
Sequence		E	L	V	S	A	A	G	K	A	L	R	D	W	D	A	L	M	V	V	E	E	G	K	P	V	G	V	I	T	R	Y	D	L	L	G	F	L	S	E	G	A	G	R	R
Secondary structure
SS confidence
Disorder		?	?																																					?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 41%) Beta strand ( 17%) TM helix ( 11%) (View membrane topology prediction)

Rank Aligned region

PDB 4l3v chain B Region: 2 - 464 Aligned: 455 Modelled: 463 Confidence: 100.0% Identity: 40% PDB header:lyase Chain: B: PDB Molecule:cystathionine beta-synthase; PDBTitle: crystal structure of delta516-525 human cystathionine beta-synthase Phyre2 PDB 3pc3 chain A Region: 2 - 463 Aligned: 452 Modelled: 462 Confidence: 100.0% Identity: 36% PDB header:lyase Chain: A: PDB Molecule:cg1753, isoform a; PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate Phyre2 PDB 5ohx chain B Region: 1 - 460 Aligned: 453 Modelled: 460 Confidence: 100.0% Identity: 36% PDB header:lyase Chain: B: PDB Molecule:cystathionine beta-synthase; PDBTitle: structure of active cystathionine b-synthase from apis mellifera Phyre2 PDB 1jbq chain D Region: 2 - 317 Aligned: 308 Modelled: 316 Confidence: 100.0% Identity: 47% PDB header:lyase Chain: D: PDB Molecule:cystathionine beta-synthase; PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein Phyre2 PDB 1jbq chain A Region: 2 - 317 Aligned: 308 Modelled: 316 Confidence: 100.0% Identity: 47% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 6c2q chain A Region: 4 - 325 Aligned: 321 Modelled: 322 Confidence: 100.0% Identity: 41% PDB header:lyase Chain: A: PDB Molecule:cystathionine beta-synthase; PDBTitle: crystal structures of cystathionine beta-synthase from saccharomyces2 cerevisiae: the structure of the plp-l-serine intermediate Phyre2 PDB 5d87 chain A Region: 4 - 315 Aligned: 309 Modelled: 312 Confidence: 100.0% Identity: 32% PDB header:biosynthetic protein Chain: A: PDB Molecule:probable siderophore biosynthesis protein sbna; PDBTitle: staphyloferrin b precursor biosynthetic enzyme sbna y152f/s185g2 variant Phyre2 PDB 5i7w chain A Region: 3 - 326 Aligned: 322 Modelled: 324 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:cysteine synthase a; PDBTitle: crystal structure of a cysteine synthase from brucella suis Phyre2 PDB 1z7w chain A domain 1 Region: 2 - 321 Aligned: 316 Modelled: 320 Confidence: 100.0% Identity: 42% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 3dwg chain A Region: 1 - 317 Aligned: 306 Modelled: 311 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:cysteine synthase b; PDBTitle: crystal structure of a sulfur carrier protein complex found in the2 cysteine biosynthetic pathway of mycobacterium tuberculosis Phyre2 PDB 2pqm chain A Region: 2 - 323 Aligned: 317 Modelled: 322 Confidence: 100.0% Identity: 32% PDB header:lyase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of cysteine synthase (oass) from entamoeba2 histolytica at 1.86 a resolution Phyre2 PDB 4aec chain B Region: 1 - 319 Aligned: 315 Modelled: 319 Confidence: 100.0% Identity: 40% PDB header:lyase Chain: B: PDB Molecule:cysteine synthase, mitochondrial; PDBTitle: crystal structure of the arabidopsis thaliana o-acetyl-serine-(thiol)-2 lyase c Phyre2 PDB 3x43 chain F Region: 3 - 312 Aligned: 304 Modelled: 310 Confidence: 100.0% Identity: 41% PDB header:transferase Chain: F: PDB Molecule:o-ureido-l-serine synthase; PDBTitle: crystal structure of o-ureido-l-serine synthase Phyre2 PDB 3vbe chain A Region: 3 - 315 Aligned: 309 Modelled: 313 Confidence: 100.0% Identity: 39% PDB header:transferase Chain: A: PDB Molecule:beta-cyanoalnine synthase; PDBTitle: crystal structure of beta-cyanoalanine synthase in soybean Phyre2 PDB 4lma chain A Region: 1 - 313 Aligned: 309 Modelled: 313 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure analysis of o-acetylserine sulfhydrylase cysk1 from2 microcystis aeruginosa 7806 Phyre2 PDB 5b1i chain C Region: 3 - 308 Aligned: 301 Modelled: 305 Confidence: 100.0% Identity: 38% PDB header:lyase Chain: C: PDB Molecule:cystathionine beta-synthase; PDBTitle: crystal structure of k42a mutant of cystathionine beta-synthase from2 lactobacillus plantarum in a complex with l-methionine Phyre2 PDB 4air chain B Region: 2 - 327 Aligned: 296 Modelled: 301 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: B: PDB Molecule:cysteine synthase; PDBTitle: leishmania major cysteine synthase Phyre2 PDB 4i1x chain A Region: 1 - 304 Aligned: 299 Modelled: 304 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of cysteine synthase from helicobacter pylori 26695 Phyre2 PDB 5xa2 chain B Region: 1 - 311 Aligned: 306 Modelled: 311 Confidence: 100.0% Identity: 43% PDB header:transferase Chain: B: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of o-acetylserine sulfhydrylase from planctomyces2 limnophila Phyre2 PDB 1ve1 chain A domain 1 Region: 6 - 306 Aligned: 296 Modelled: 301 Confidence: 100.0% Identity: 46% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 1 c4l3vB_ 2 c3pc3A_ 3 c5ohxB_ 4 c1jbqD_ 5 d1jbqa_ 6 c6c2qA_ 7 c5d87A_ 8 c5i7wA_ 9 d1z7wa1 10 c3dwgA_ 11 c2pqmA_ 12 c4aecB_ 13 c3x43F_ 14 c3vbeA_ 15 c4lmaA_ 16 c5b1iC_ 17 c4airB_ 18 c4i1xA_ 19 c5xa2B_ 20 d1ve1a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499