1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	D	T	Q	V	T	W	L	T	Q	E	S	H	D	R	L	K	A	E	L	D	Q	L	I	A	N	R	P	V	I	A	A	E	I	N	D	R	R	E	E	G	D	L	R	E	N	G	G	Y	H	A	A	R	E	E	Q	G	Q	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	A	R	I	R	Q	L	Q	D	L	L	S	N	A	K	V	G	E	A	P	K	Q	S	G	V	A	L	P	G	S	V	V	K	V	Y	Y	N	G	D	K	S	D	S	E	T	F	L	I	A	T	R	Q	E	G	V	S	D	G	K	L
Secondary structure
SS confidence
Disorder																?		?	?	?	?	?	?	?	?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.
Sequence		E	V	Y	S	P	N	S	P	L	G	G	A	L	I	D	A	K	V	G	E	T	R	S	Y	T	V	P	N	G	S	T	V	S	V	T	L	V	S	A	E	P	Y	H	S
Secondary structure
SS confidence
Disorder																																										?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 40%) Beta strand ( 26%)

Rank Aligned region

PDB 2p4v chain A Region: 5 - 162 Aligned: 153 Modelled: 158 Confidence: 100.0% Identity: 24% PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor greb; PDBTitle: crystal structure of the transcript cleavage factor, greb2 at 2.6a resolution Phyre2 PDB 1grj chain A Region: 5 - 161 Aligned: 147 Modelled: 157 Confidence: 100.0% Identity: 33% PDB header:transcription regulation Chain: A: PDB Molecule:grea protein; PDBTitle: grea transcript cleavage factor from escherichia coli Phyre2 PDB 2etn chain A Region: 5 - 160 Aligned: 151 Modelled: 156 Confidence: 100.0% Identity: 27% PDB header:transcription Chain: A: PDB Molecule:anti-cleavage anti-grea transcription factor PDBTitle: crystal structure of thermus aquaticus gfh1 Phyre2 PDB 3bmb chain B Region: 3 - 161 Aligned: 124 Modelled: 127 Confidence: 99.9% Identity: 19% PDB header:rna binding protein Chain: B: PDB Molecule:regulator of nucleoside diphosphate kinase; PDBTitle: crystal structure of a new rna polymerase interacting2 protein Phyre2 PDB 2pn0 chain D Region: 6 - 161 Aligned: 117 Modelled: 118 Confidence: 99.9% Identity: 24% PDB header:transcription Chain: D: PDB Molecule:prokaryotic transcription elongation factor PDBTitle: prokaryotic transcription elongation factor grea/greb from2 nitrosomonas europaea Phyre2 PDB 1grj chain A domain 1 Region: 5 - 81 Aligned: 77 Modelled: 77 Confidence: 99.9% Identity: 47% Fold: Long alpha-hairpin Superfamily: GreA transcript cleavage protein, N-terminal domain Family: GreA transcript cleavage protein, N-terminal domain Phyre2 PDB 2f23 chain A domain 1 Region: 5 - 78 Aligned: 74 Modelled: 74 Confidence: 99.9% Identity: 28% Fold: Long alpha-hairpin Superfamily: GreA transcript cleavage protein, N-terminal domain Family: GreA transcript cleavage protein, N-terminal domain Phyre2 PDB 2f23 chain A domain 2 Region: 82 - 160 Aligned: 77 Modelled: 79 Confidence: 99.8% Identity: 25% Fold: FKBP-like Superfamily: FKBP-like Family: GreA transcript cleavage factor, C-terminal domain Phyre2 PDB 2etn chain A domain 2 Region: 82 - 160 Aligned: 77 Modelled: 79 Confidence: 99.7% Identity: 23% Fold: FKBP-like Superfamily: FKBP-like Family: GreA transcript cleavage factor, C-terminal domain Phyre2 PDB 1grj chain A domain 2 Region: 81 - 161 Aligned: 71 Modelled: 81 Confidence: 99.7% Identity: 18% Fold: FKBP-like Superfamily: FKBP-like Family: GreA transcript cleavage factor, C-terminal domain Phyre2 PDB 3gty chain X Region: 60 - 160 Aligned: 89 Modelled: 101 Confidence: 95.3% Identity: 15% PDB header:chaperone/ribosomal protein Chain: X: PDB Molecule:trigger factor; PDBTitle: promiscuous substrate recognition in folding and assembly activities2 of the trigger factor chaperone Phyre2 PDB 1w26 chain B Region: 60 - 160 Aligned: 90 Modelled: 101 Confidence: 92.4% Identity: 16% PDB header:chaperone Chain: B: PDB Molecule:trigger factor; PDBTitle: trigger factor in complex with the ribosome forms a2 molecular cradle for nascent proteins Phyre2 PDB 1t11 chain A domain 3 Region: 58 - 156 Aligned: 88 Modelled: 99 Confidence: 91.1% Identity: 14% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 1w26 chain A domain 3 Region: 60 - 156 Aligned: 88 Modelled: 93 Confidence: 89.8% Identity: 14% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 1t11 chain A Region: 60 - 160 Aligned: 90 Modelled: 101 Confidence: 88.2% Identity: 13% PDB header:chaperone Chain: A: PDB Molecule:trigger factor; PDBTitle: trigger factor Phyre2 PDB 1krh chain A domain 1 Region: 88 - 150 Aligned: 62 Modelled: 63 Confidence: 78.6% Identity: 23% Fold: Reductase/isomerase/elongation factor common domain Superfamily: Riboflavin synthase domain-like Family: Ferredoxin reductase FAD-binding domain-like Phyre2 PDB 1l1p chain A Region: 129 - 160 Aligned: 32 Modelled: 32 Confidence: 74.7% Identity: 25% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 5zr0 chain A Region: 132 - 156 Aligned: 25 Modelled: 25 Confidence: 72.4% Identity: 24% PDB header:chaperone Chain: A: PDB Molecule:maltose-binding periplasmic protein,trigger factor; PDBTitle: solution structure of peptidyl-prolyl cis/trans isomerase domain of2 trigger factor in complex with mbp Phyre2 PDB 2dq0 chain A Region: 14 - 75 Aligned: 57 Modelled: 62 Confidence: 67.1% Identity: 25% PDB header:ligase Chain: A: PDB Molecule:seryl-trna synthetase; PDBTitle: crystal structure of seryl-trna synthetase from pyrococcus2 horikoshii complexed with a seryl-adenylate analog Phyre2 PDB 1q1c chain A domain 1 Region: 88 - 161 Aligned: 74 Modelled: 74 Confidence: 64.5% Identity: 24% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 1 c2p4vA_ 2 c1grjA_ 3 c2etnA_ 4 c3bmbB_ 5 c2pn0D_ 6 d1grja1 7 d2f23a1 8 d2f23a2 9 d2etna2 10 d1grja2 11 c3gtyX_ 12 c1w26B_ 13 d1t11a3 14 d1w26a3 15 c1t11A_ 16 d1krha1 17 d1l1pa_ 18 c5zr0A_ 19 c2dq0A_ 20 d1q1ca1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99