1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	G	Q	A	D	T	A	T	T	A	E	A	R	T	P	A	H	A	A	H	H	L	V	E	G	V	A	R	V	L	T	K	P	R	F	R	G	W	I	H	V	Y	S	A	G	T	A	V	L	A	G	A	S	L	V	A	V	S	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?									?			?																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	V	G	S	A	K	A	G	L	T	T	L	A	Y	T	A	A	T	I	T	M	F	T	V	S	A	T	Y	H	R	V	N	W	K	S	A	T	A	R	N	W	M	K	R	A	D	H	S	M	I	F	V	F	I	A	G	S	Y	T	P
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	A	L	L	A	L	P	A	H	D	G	R	V	V	L	S	I	V	W	G	G	A	I	A	G	I	L	L	K	M	C	W	P	A	A	P	R	S	V	G	V	P	L	Y	L	L	L	G	W	V	A	V	W	Y	T	A	T	I	L	H
Secondary structure
SS confidence
Disorder																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	A	G	V	T	A	L	V	L	L	F	V	G	G	A	L	Y	S	I	G	G	I	L	Y	A	V	R	W	P	D	P	W	P	T	T	F	G	Y	H	E	F	F	H	A	C	T	A	V	A	A	I	C	H	Y	I	A	M	W	F	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.
Sequence		V	F
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 75%) Beta strand ( 0%) TM helix ( 57%) (View membrane topology prediction)

Rank Aligned region

PDB 3wxv chain A Region: 34 - 240 Aligned: 207 Modelled: 207 Confidence: 100.0% Identity: 20% PDB header:membrane protein/immune system Chain: A: PDB Molecule:adiponectin receptor protein 1; PDBTitle: crystal structure of the human adiponectin receptor 1 Phyre2 PDB 6g7o chain A Region: 34 - 235 Aligned: 187 Modelled: 202 Confidence: 98.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:alkaline ceramidase 3,soluble cytochrome b562; PDBTitle: crystal structure of human alkaline ceramidase 3 (acer3) at 2.72 angstrom resolution Phyre2 PDB 4ymk chain A Region: 2 - 105 Aligned: 92 Modelled: 104 Confidence: 45.3% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa desaturase 1; PDBTitle: crystal structure of stearoyl-coenzyme a desaturase 1 Phyre2 PDB 1xl3 chain C domain 1 Region: 213 - 224 Aligned: 12 Modelled: 12 Confidence: 26.4% Identity: 25% Fold: Type III secretion system domain Superfamily: Type III secretion system domain Family: TyeA-like Phyre2 PDB 6adq chain P Region: 1 - 85 Aligned: 82 Modelled: 82 Confidence: 25.5% Identity: 10% PDB header:electron transport Chain: P: PDB Molecule:prokaryotic respiratory supercomplex associate factor 1 PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 PDB 4pgu chain A Region: 96 - 216 Aligned: 121 Modelled: 121 Confidence: 20.3% Identity: 7% PDB header:membrance protein Chain: A: PDB Molecule:uncharacterized protein yetj; PDBTitle: crystal structure of yetj from bacillus subtilis at ph 7 by soaking Phyre2 PDB 2khs chain B Region: 15 - 40 Aligned: 26 Modelled: 26 Confidence: 17.8% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:nuclease; PDBTitle: solution structure of snase121:snase(111-143) complex Phyre2 PDB 5aja chain C Region: 4 - 28 Aligned: 24 Modelled: 25 Confidence: 17.3% Identity: 25% PDB header:viral protein Chain: C: PDB Molecule:sam domain and hd domain-containing protein; PDBTitle: crystal structure of mandrill samhd1 (amino acid residues 1-114)2 bound to vpx isolated from mandrill and human dcaf1 (amino3 acid residues 1058-1396) Phyre2 PDB 1dxs chain A Region: 205 - 222 Aligned: 13 Modelled: 18 Confidence: 17.2% Identity: 15% Fold: SAM domain-like Superfamily: SAM/Pointed domain Family: SAM (sterile alpha motif) domain Phyre2 PDB 2e74 chain G domain 1 Region: 190 - 205 Aligned: 16 Modelled: 16 Confidence: 14.7% Identity: 38% Fold: Single transmembrane helix Superfamily: PetG subunit of the cytochrome b6f complex Family: PetG subunit of the cytochrome b6f complex Phyre2 PDB 1vf5 chain G Region: 190 - 205 Aligned: 16 Modelled: 16 Confidence: 14.5% Identity: 38% PDB header:photosynthesis Chain: G: PDB Molecule:protein pet g; PDBTitle: crystal structure of cytochrome b6f complex from m.laminosus Phyre2 PDB 1vf5 chain G Region: 190 - 205 Aligned: 16 Modelled: 16 Confidence: 14.5% Identity: 38% Fold: Single transmembrane helix Superfamily: PetG subunit of the cytochrome b6f complex Family: PetG subunit of the cytochrome b6f complex Phyre2 PDB 6bwd chain C Region: 6 - 116 Aligned: 108 Modelled: 111 Confidence: 12.3% Identity: 12% PDB header:membrane protein Chain: C: PDB Molecule:transient receptor potential cation channel subfamily m PDBTitle: 3.7 angstrom cryoem structure of truncated mouse trpm7 Phyre2 PDB 6bwd chain D Region: 6 - 116 Aligned: 108 Modelled: 111 Confidence: 12.3% Identity: 12% PDB header:membrane protein Chain: D: PDB Molecule:transient receptor potential cation channel subfamily m PDBTitle: 3.7 angstrom cryoem structure of truncated mouse trpm7 Phyre2 PDB 6bwd chain A Region: 6 - 116 Aligned: 108 Modelled: 111 Confidence: 12.3% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:transient receptor potential cation channel subfamily m PDBTitle: 3.7 angstrom cryoem structure of truncated mouse trpm7 Phyre2 PDB 6bwd chain B Region: 6 - 116 Aligned: 108 Modelled: 111 Confidence: 12.3% Identity: 12% PDB header:membrane protein Chain: B: PDB Molecule:transient receptor potential cation channel subfamily m PDBTitle: 3.7 angstrom cryoem structure of truncated mouse trpm7 Phyre2 PDB 6bwf chain A Region: 6 - 116 Aligned: 107 Modelled: 111 Confidence: 11.7% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:trpm7; PDBTitle: 4.1 angstrom mg2+-unbound structure of mouse trpm7 Phyre2 PDB 6bwf chain D Region: 6 - 116 Aligned: 107 Modelled: 111 Confidence: 11.7% Identity: 14% PDB header:membrane protein Chain: D: PDB Molecule:trpm7; PDBTitle: 4.1 angstrom mg2+-unbound structure of mouse trpm7 Phyre2 PDB 6bwf chain B Region: 6 - 116 Aligned: 107 Modelled: 111 Confidence: 11.7% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:trpm7; PDBTitle: 4.1 angstrom mg2+-unbound structure of mouse trpm7 Phyre2 PDB 6bwf chain C Region: 6 - 116 Aligned: 107 Modelled: 111 Confidence: 11.7% Identity: 14% PDB header:membrane protein Chain: C: PDB Molecule:trpm7; PDBTitle: 4.1 angstrom mg2+-unbound structure of mouse trpm7 Phyre2 1 c3wxvA_ 2 c6g7oA_ 3 c4ymkA_ 4 d1xl3c1 5 c6adqP_ 6 c4pguA_ 7 c2khsB_ 8 c5ajaC_ 9 d1dxsa_ 10 d2e74g1 11 c1vf5G_ 12 d1vf5g_ 13 c6bwdC_ 14 c6bwdD_ 15 c6bwdA_ 16 c6bwdB_ 17 c6bwfA_ 18 c6bwfD_ 19 c6bwfB_ 20 c6bwfC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43