1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	Q	K	P	V	A	D	A	L	T	L	E	L	E	P	V	V	E	A	N	M	T	R	H	L	D	T	E	D	I	W	F	A	H	D	Y	V	P	F	D	Q	G	E	N	F	A	F	L	G	G	R	D	W	D	P	S	Q	S	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																										?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	P	R	T	I	T	D	A	C	E	I	L	L	I	L	K	D	N	L	A	G	H	H	R	E	L	V	E	H	F	I	L	E	D	W	W	G	R	W	L	G	R	W	T	A	E	E	H	L	H	A	I	A	L	R	E	Y	L	V	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	R	E	V	D	P	V	A	N	E	D	V	R	V	Q	H	V	M	K	G	Y	R	A	E	K	Y	T	Q	V	E	T	L	V	Y	M	A	F	Y	E	R	C	G	A	V	F	C	R	N	L	A	A	Q	I	E	E	P	I	L	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	I	D	R	I	A	R	D	E	V	R	H	E	E	F	F	A	N	L	V	T	H	C	L	D	Y	T	R	D	E	T	I	A	A	I	A	A	R	A	A	D	L	D	V	L	G	A	D	I	E	A	Y	R	D	K	L	Q	N	V	A
Secondary structure
SS confidence
Disorder																																									?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.
Sequence		D	A	G	I	F	G	K	P	Q	L	R	Q	L	I	S	D	R	I	T	A	W	G	L	A	G	E	P	S	L	K	Q	F	V	T	G
Secondary structure
SS confidence
Disorder																									?									?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 72%) Beta strand ( 0%)

Rank Aligned region

PDB 1afr chain A Region: 2 - 269 Aligned: 267 Modelled: 268 Confidence: 100.0% Identity: 21% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1za0 chain A domain 1 Region: 8 - 274 Aligned: 242 Modelled: 252 Confidence: 100.0% Identity: 100% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 5hyh chain A Region: 8 - 266 Aligned: 256 Modelled: 259 Confidence: 98.5% Identity: 12% PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: cmli (chemically reduced state), arylamine oxygenase of2 chloramphenicol biosynthetic pathway Phyre2 PDB 3hf1 chain B Region: 16 - 219 Aligned: 193 Modelled: 198 Confidence: 98.5% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase subunit m2 b; PDBTitle: crystal structure of human p53r2 Phyre2 PDB 1h0o chain A Region: 16 - 219 Aligned: 191 Modelled: 204 Confidence: 98.5% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: cobalt substitution of mouse r2 ribonucleotide reductase to2 model the reactive diferrous state Phyre2 PDB 1w68 chain A Region: 16 - 219 Aligned: 194 Modelled: 202 Confidence: 98.4% Identity: 13% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 2p1i chain A Region: 16 - 219 Aligned: 186 Modelled: 204 Confidence: 98.4% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleotide reductase, small chain; PDBTitle: plasmodium yoelii ribonucleotide reductase subunit r2 (py03671) Phyre2 PDB 1uzr chain A Region: 16 - 222 Aligned: 193 Modelled: 207 Confidence: 98.4% Identity: 15% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 2o1z chain A Region: 16 - 219 Aligned: 187 Modelled: 204 Confidence: 98.3% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleotide reductase subunit r2; PDBTitle: plasmodium vivax ribonucleotide reductase subunit r2 (pv086155) Phyre2 PDB 3cht chain A Region: 26 - 269 Aligned: 239 Modelled: 244 Confidence: 98.3% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:p-aminobenzoate n-oxygenase; PDBTitle: crystal structure of di-iron aurf with partially bound ligand Phyre2 PDB 1sms chain A Region: 16 - 219 Aligned: 194 Modelled: 198 Confidence: 98.3% Identity: 15% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1jk0 chain B Region: 16 - 219 Aligned: 185 Modelled: 196 Confidence: 98.3% Identity: 18% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1oqu chain C Region: 16 - 221 Aligned: 191 Modelled: 206 Confidence: 98.2% Identity: 14% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1r2f chain B Region: 16 - 222 Aligned: 195 Modelled: 207 Confidence: 98.2% Identity: 14% PDB header:oxidoreductase Chain: B: PDB Molecule:protein (ribonucleotide reductase r2); PDBTitle: ribonucleotide reductase r2f protein from salmonella2 typhimurium Phyre2 PDB 2rcc chain C Region: 16 - 222 Aligned: 196 Modelled: 207 Confidence: 98.2% Identity: 17% PDB header:oxidoreductase Chain: C: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of putative class i ribonucleotide reductase2 (np_241368.1) from bacillus halodurans at 1.90 a resolution Phyre2 PDB 2vux chain B Region: 16 - 219 Aligned: 177 Modelled: 192 Confidence: 98.2% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase subunit m2 b; PDBTitle: human ribonucleotide reductase, subunit m2 b Phyre2 PDB 4bmt chain B Region: 16 - 222 Aligned: 197 Modelled: 207 Confidence: 98.1% Identity: 18% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of ribonucleotide reductase di-iron nrdf2 from bacillus cereus Phyre2 PDB 3dhz chain A domain 1 Region: 16 - 222 Aligned: 195 Modelled: 207 Confidence: 98.1% Identity: 14% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1smq chain D Region: 16 - 219 Aligned: 189 Modelled: 193 Confidence: 98.1% Identity: 15% PDB header:oxidoreductase Chain: D: PDB Molecule:ribonucleoside-diphosphate reductase small chain PDBTitle: structure of the ribonucleotide reductase rnr2 homodimer2 from saccharomyces cerevisiae Phyre2 PDB 4n83 chain F Region: 16 - 221 Aligned: 192 Modelled: 206 Confidence: 98.1% Identity: 11% PDB header:oxidoreductase Chain: F: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: x-ray crystal structure of streptococcus sanguinis dimanganese(ii)-2 nrdf Phyre2 1 d1afra_ 2 d1za0a1 3 c5hyhA_ 4 c3hf1B_ 5 c1h0oA_ 6 d1w68a_ 7 c2p1iA_ 8 d1uzra_ 9 c2o1zA_ 10 c3chtA_ 11 d1smsa_ 12 d1jk0b_ 13 d1oquc_ 14 c1r2fB_ 15 c2rccC_ 16 c2vuxB_ 17 c4bmtB_ 18 d3dhza1 19 c1smqD_ 20 c4n83F_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135