1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	N	T	E	F	T	L	T	Q	K	R	A	L	A	I	L	T	L	I	A	L	L	F	G	A	Y	F	L	R	N	Y	F	V	L	I	V	V	A	A	V	G	A	Y	L	F	T	P	L	F	K	W	F	T	K	R	F	N	T	G	L
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	A	A	C	T	L	L	S	A	L	A	A	V	V	V	P	V	G	A	L	V	G	L	A	I	V	Q	I	A	R	M	V	D	S	V	A	D	W	V	R	T	T	D	L	S	T	L	G	D	K	I	L	Q	F	V	N	G	L	F	D
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	V	P	F	L	H	I	T	V	T	A	D	A	L	R	K	A	M	I	S	V	A	Q	N	V	G	E	W	L	L	H	F	L	R	D	A	A	G	S	L	A	G	V	I	T	S	A	I	I	F	V	Y	V	F	V	A	L	L	V	N
Secondary structure
SS confidence
Disorder		?	?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	E	K	L	R	T	L	I	G	Q	L	N	P	L	G	E	D	V	T	D	L	Y	L	Q	K	M	G	S	M	V	R	G	T	V	N	G	Q	F	V	I	A	A	C	Q	G	V	A	G	A	A	S	I	Y	I	A	G	F	H	H	G
Secondary structure
SS confidence
Disorder															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	F	I	F	A	I	V	L	T	A	L	S	I	I	P	L	G	G	G	I	V	T	I	P	F	G	I	G	M	I	F	Y	G	N	I	A	G	G	I	F	V	L	L	W	H	L	L	V	V	T	N	I	D	N	V	L	R	P	I	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	P	R	D	A	R	L	N	S	A	L	M	L	L	S	V	F	A	G	I	T	M	F	G	P	W	G	I	I	I	G	P	V	L	M	I	L	I	V	T	T	I	D	V	Y	L	A	V	Y	K	G	V	E	L	E	Q	F	E	A	P
Secondary structure
SS confidence
Disorder		?	?	?		?																																														?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.
Sequence		P	V	R	R	R	W	L	P	R	R	G	P	A	T	S	R	N	A	P	P	P	S	T	A	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 77%) Beta strand ( 1%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 1kkx chain A Region: 298 - 362 Aligned: 65 Modelled: 65 Confidence: 55.4% Identity: 18% Fold: DNA/RNA-binding 3-helical bundle Superfamily: ARID-like Family: ARID domain Phyre2 PDB 3b60 chain A domain 2 Region: 10 - 213 Aligned: 194 Modelled: 204 Confidence: 44.1% Identity: 11% Fold: ABC transporter transmembrane region Superfamily: ABC transporter transmembrane region Family: ABC transporter transmembrane region Phyre2 PDB 3qf4 chain B Region: 10 - 218 Aligned: 199 Modelled: 209 Confidence: 40.6% Identity: 6% PDB header:transport protein Chain: B: PDB Molecule:uncharacterized abc transporter atp-binding protein PDBTitle: crystal structure of a heterodimeric abc transporter in its inward-2 facing conformation Phyre2 PDB 5u1d chain B Region: 1 - 292 Aligned: 282 Modelled: 282 Confidence: 24.6% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:antigen peptide transporter 2; PDBTitle: cryo-em structure of the human tap atp-binding cassette transporter Phyre2 PDB 5c76 chain D Region: 1 - 213 Aligned: 213 Modelled: 213 Confidence: 17.2% Identity: 11% PDB header:transport protein Chain: D: PDB Molecule:wlab protein; PDBTitle: atp-driven lipid-linked oligosaccharide flippase pglk in apo-inward2 facing state (2) Phyre2 PDB 4pl0 chain B Region: 5 - 289 Aligned: 278 Modelled: 285 Confidence: 17.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:microcin-j25 export atp-binding/permease protein mcjd; PDBTitle: crystal structure of the antibacterial peptide abc transporter mcjd in2 an outward occluded state Phyre2 PDB 4yzf chain A Region: 169 - 255 Aligned: 85 Modelled: 87 Confidence: 16.9% Identity: 15% PDB header:immune system Chain: A: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the anion exchanger domain of human erythrocyte2 band 3 Phyre2 PDB 5jnq chain A Region: 23 - 97 Aligned: 75 Modelled: 75 Confidence: 15.3% Identity: 15% PDB header:transferase/antibiotic Chain: A: PDB Molecule:phospho-n-acetylmuramoyl-pentapeptide-transferase; PDBTitle: mray tunicamycin complex Phyre2 PDB 1ryu chain A Region: 298 - 365 Aligned: 68 Modelled: 68 Confidence: 11.8% Identity: 9% Fold: DNA/RNA-binding 3-helical bundle Superfamily: ARID-like Family: ARID domain Phyre2 PDB 3rlb chain A Region: 260 - 361 Aligned: 92 Modelled: 102 Confidence: 11.1% Identity: 13% PDB header:thiamine-binding protein Chain: A: PDB Molecule:thit; PDBTitle: crystal structure at 2.0 a of the s-component for thiamin from an ecf-2 type abc transporter Phyre2 PDB 3b5w chain E Region: 29 - 213 Aligned: 185 Modelled: 185 Confidence: 8.7% Identity: 10% PDB header:membrane protein Chain: E: PDB Molecule:lipid a export atp-binding/permease protein msba; PDBTitle: crystal structure of eschericia coli msba Phyre2 PDB 1ig6 chain A Region: 298 - 367 Aligned: 70 Modelled: 70 Confidence: 8.5% Identity: 13% Fold: DNA/RNA-binding 3-helical bundle Superfamily: ARID-like Family: ARID domain Phyre2 PDB 3qf4 chain A Region: 10 - 291 Aligned: 272 Modelled: 282 Confidence: 8.3% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:abc transporter, atp-binding protein; PDBTitle: crystal structure of a heterodimeric abc transporter in its inward-2 facing conformation Phyre2 PDB 4p6v chain B Region: 8 - 61 Aligned: 54 Modelled: 54 Confidence: 8.2% Identity: 17% PDB header:oxidoreductase Chain: B: PDB Molecule:na(+)-translocating nadh-quinone reductase subunit b; PDBTitle: crystal structure of the na+-translocating nadh: ubiquinone2 oxidoreductase from vibrio cholerae Phyre2 PDB 2b6p chain A Region: 306 - 385 Aligned: 80 Modelled: 80 Confidence: 8.1% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:lens fiber major intrinsic protein; PDBTitle: x-ray structure of lens aquaporin-0 (aqp0) (lens mip) in an open pore2 state Phyre2 PDB 5nf2 chain A Region: 355 - 385 Aligned: 31 Modelled: 31 Confidence: 8.1% Identity: 10% PDB header:cell adhesion Chain: A: PDB Molecule:minor fimbrium subunit mfa1; PDBTitle: the fimbrial shaft protein mfa1 from porphyromonas gingivalis Phyre2 PDB 3j2w chain E Region: 321 - 347 Aligned: 27 Modelled: 27 Confidence: 8.1% Identity: 26% PDB header:virus Chain: E: PDB Molecule:glycoprotein e1; PDBTitle: electron cryo-microscopy of chikungunya virus Phyre2 PDB 3j2w chain H Region: 321 - 347 Aligned: 27 Modelled: 27 Confidence: 8.1% Identity: 26% PDB header:virus Chain: H: PDB Molecule:glycoprotein e1; PDBTitle: electron cryo-microscopy of chikungunya virus Phyre2 PDB 3j7k chain F Region: 302 - 313 Aligned: 12 Modelled: 12 Confidence: 7.9% Identity: 25% PDB header:translation Chain: F: PDB Molecule:eukaryotic translation initiation factor 3 subunit f; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s em map Phyre2 PDB 3j7j chain F Region: 302 - 313 Aligned: 12 Modelled: 12 Confidence: 7.9% Identity: 25% PDB header:translation Chain: F: PDB Molecule:eukaryotic translation initiation factor 3 subunit f; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s-hcv ires2 em map Phyre2 1 d1kkxa_ 2 d3b60a2 3 c3qf4B_ 4 c5u1dB_ 5 c5c76D_ 6 c4pl0B_ 7 c4yzfA_ 8 c5jnqA_ 9 d1ryua_ 10 c3rlbA_ 11 c3b5wE_ 12 d1ig6a_ 13 c3qf4A_ 14 c4p6vB_ 15 c2b6pA_ 16 c5nf2A_ 17 c3j2wE_ 18 c3j2wH_ 19 c3j7kF_ 20 c3j7jF_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39