1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	P	I	H	I	A	Q	L	D	K	A	R	P	V	L	I	L	T	R	E	V	V	R	P	H	L	T	N	V	T	V	A	P	I	T	T	T	V	R	G	L	A	T	E	V	P	V	D	A	V	N	G	L	N	Q	P	S	V	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?															?	?	?	?																								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.
Sequence		S	C	D	N	T	Q	T	I	P	V	C	D	L	G	R	Q	I	G	Y	L	L	A	S	Q	E	P	A	L	A	E	A	I	G	N	A	F	D	L	D	W	V	V	A
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 25%) Beta strand ( 27%)

Rank Aligned region

PDB 5cca chain A Region: 1 - 98 Aligned: 94 Modelled: 98 Confidence: 100.0% Identity: 98% PDB header:hydrolase Chain: A: PDB Molecule:endoribonuclease mazf3; PDBTitle: crystal structure of mtb toxin Phyre2 PDB 4mzp chain C Region: 1 - 99 Aligned: 99 Modelled: 99 Confidence: 99.9% Identity: 21% PDB header:hydrolase Chain: C: PDB Molecule:mazf mrna interferase; PDBTitle: mazf from s. aureus crystal form iii, c2221, 2.7 a Phyre2 PDB 1m1f chain A Region: 1 - 96 Aligned: 95 Modelled: 96 Confidence: 99.9% Identity: 22% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: Kid/PemK Phyre2 PDB 5hjz chain A Region: 1 - 98 Aligned: 98 Modelled: 98 Confidence: 99.9% Identity: 22% PDB header:hydrolase/rna Chain: A: PDB Molecule:endoribonuclease mazf9; PDBTitle: structure of m. tuberculosis mazf-mt1 (rv2801c) in complex with rna Phyre2 PDB 1ne8 chain A Region: 1 - 99 Aligned: 99 Modelled: 99 Confidence: 99.9% Identity: 24% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: Kid/PemK Phyre2 PDB 1ub4 chain A Region: 1 - 97 Aligned: 87 Modelled: 97 Confidence: 99.9% Identity: 18% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: Kid/PemK Phyre2 PDB 5wyg chain C Region: 2 - 99 Aligned: 98 Modelled: 98 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:probable endoribonuclease mazf7; PDBTitle: the crystal structure of the apo form of mtb mazf Phyre2 PDB 5xe3 chain B Region: 11 - 100 Aligned: 83 Modelled: 82 Confidence: 99.9% Identity: 24% PDB header:hydrolase/antitoxin Chain: B: PDB Molecule:endoribonuclease mazf4; PDBTitle: endoribonuclease in complex with its cognate antitoxin from2 mycobacterial species Phyre2 PDB 5hk3 chain B Region: 9 - 98 Aligned: 90 Modelled: 90 Confidence: 99.9% Identity: 26% PDB header:hydrolase/dna Chain: B: PDB Molecule:endoribonuclease mazf6; PDBTitle: crystal structure of m. tuberculosis mazf-mt3 t52d-f62d mutant in2 complex with dna Phyre2 PDB 3jrz chain A Region: 6 - 96 Aligned: 86 Modelled: 91 Confidence: 97.1% Identity: 12% PDB header:toxin Chain: A: PDB Molecule:ccdb; PDBTitle: ccdbvfi-formii-ph5.6 Phyre2 PDB 3vub chain A Region: 10 - 96 Aligned: 80 Modelled: 87 Confidence: 96.6% Identity: 18% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: CcdB Phyre2 PDB 3d55 chain A Region: 2 - 25 Aligned: 22 Modelled: 24 Confidence: 11.0% Identity: 14% PDB header:toxin inhibitor Chain: A: PDB Molecule:uncharacterized protein rv3357/mt3465; PDBTitle: crystal structure of m. tuberculosis yefm antitoxin Phyre2 PDB 6bwq chain B Region: 9 - 19 Aligned: 11 Modelled: 11 Confidence: 8.8% Identity: 45% PDB header:metal binding protein Chain: B: PDB Molecule:pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel PDBTitle: larc2, the c-terminal domain of a cyclometallase involved in the2 synthesis of the npn cofactor of lactate racemase, in complex with3 mnctp Phyre2 PDB 3c19 chain A Region: 9 - 19 Aligned: 11 Modelled: 11 Confidence: 8.8% Identity: 36% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein mk0293; PDBTitle: crystal structure of protein mk0293 from methanopyrus kandleri av19 Phyre2 PDB 1rz4 chain A domain 1 Region: 66 - 92 Aligned: 27 Modelled: 27 Confidence: 8.3% Identity: 26% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Eukaryotic translation initiation factor 3 subunit 12, eIF3k, C-terminal domain Phyre2 PDB 6n1b chain A Region: 1 - 24 Aligned: 24 Modelled: 24 Confidence: 7.8% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:carbohydrate-binding protein; PDBTitle: crystal structure of an n-acetylgalactosamine deacetylase from f.2 plautii in complex with blood group b trisaccharide Phyre2 PDB 4bxt chain D Region: 82 - 98 Aligned: 17 Modelled: 17 Confidence: 6.9% Identity: 12% PDB header:viral protein Chain: D: PDB Molecule:phosphoprotein p; PDBTitle: crystal structure of the human metapneumovirus2 phosphoprotein tetramerization domain Phyre2 PDB 5oiy chain G Region: 82 - 98 Aligned: 17 Modelled: 17 Confidence: 6.9% Identity: 12% PDB header:viral protein Chain: G: PDB Molecule:phosphoprotein; PDBTitle: structure of the hmpv p oligomerization domain at 2.2 a Phyre2 PDB 5oix chain A Region: 82 - 98 Aligned: 17 Modelled: 17 Confidence: 6.9% Identity: 12% PDB header:viral protein Chain: A: PDB Molecule:phosphoprotein; PDBTitle: structure of the hmpv p oligomerization domain at 1.6 a Phyre2 PDB 5oiy chain E Region: 82 - 98 Aligned: 17 Modelled: 17 Confidence: 6.9% Identity: 12% PDB header:viral protein Chain: E: PDB Molecule:phosphoprotein; PDBTitle: structure of the hmpv p oligomerization domain at 2.2 a Phyre2 1 c5ccaA_ 2 c4mzpC_ 3 d1m1fa_ 4 c5hjzA_ 5 d1ne8a_ 6 d1ub4a_ 7 c5wygC_ 8 c5xe3B_ 9 c5hk3B_ 10 c3jrzA_ 11 d3vuba_ 12 c3d55A_ 13 c6bwqB_ 14 c3c19A_ 15 d1rz4a1 16 c6n1bA_ 17 c4bxtD_ 18 c5oiyG_ 19 c5oixA_ 20 c5oiyE_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46