1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	Q	N	S	A	E	N	P	F	P	V	R	A	V	A	I	R	V	A	G	W	I	D	K	L	G	A	V	W	V	E	G	Q	L	A	Q	I	T	M	R	P	D	A	K	T	V	F	M	V	L	R	D	P	A	A	D	M	S	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	V	T	C	S	R	D	L	V	L	S	A	P	V	K	L	A	E	G	V	Q	V	V	V	C	G	K	P	S	F	Y	T	G	R	G	T	F	S	L	R	L	S	E	I	R	A	V	G	I	G	E	L	L	A	R	I	D	R	L	R
Secondary structure
SS confidence
Disorder								?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	L	L	D	A	E	G	L	F	D	P	R	L	K	R	P	I	P	Y	L	P	N	M	I	G	L	I	T	G	R	A	S	A	A	E	R	D	V	T	T	V	A	S	A	R	W	P	A	A	R	F	A	V	R	N	V	A	V	Q	G
Secondary structure
SS confidence
Disorder								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	N	A	V	G	Q	I	V	E	A	L	R	E	L	D	R	D	P	D	V	D	V	I	V	L	A	R	G	G	G	S	V	E	D	L	L	P	F	S	D	E	T	L	C	R	A	I	A	A	C	R	T	P	V	V	S	A	V	G	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	P	D	N	P	L	C	D	L	V	V	D	L	R	A	A	T	P	T	D	A	A	K	K	V	V	P	D	T	A	A	E	Q	R	L	I	D	D	L	R	R	R	S	A	Q	A	L	R	N	W	V	S	R	E	Q	R	A	V	A	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	R	S	R	P	V	L	A	D	P	M	T	M	V	S	V	R	A	E	E	V	H	R	A	R	S	T	L	R	R	N	L	T	L	M	V	A	A	E	T	E	R	I	G	H	L	A	A	R	L	A	T	L	G	P	A	A	T	L	A
Secondary structure
SS confidence
Disorder									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.
Sequence		R	G	Y	A	I	V	Q	T	V	A	Q	T	G	P	E	G	G	S	E	P	Q	V	L	R	S	V	H	D	A	P	E	G	T	K	L	R	V	R	V	A	D	G	A	L	A	A	V	S	E	G	Q	T	N	G	L
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?				?		?				?	?	?																			?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 45%) Beta strand ( 25%)

Rank Aligned region

PDB 3f2c chain A Region: 19 - 106 Aligned: 88 Modelled: 88 Confidence: 97.1% Identity: 13% PDB header:transferase/dna Chain: A: PDB Molecule:geobacillus kaustophilus dna polc; PDBTitle: dna polymerase polc from geobacillus kaustophilus complex with dna,2 dgtp and mn Phyre2 PDB 3kf6 chain A Region: 27 - 126 Aligned: 96 Modelled: 100 Confidence: 97.1% Identity: 13% PDB header:structural protein Chain: A: PDB Molecule:protein stn1; PDBTitle: crystal structure of s. pombe stn1-ten1 complex Phyre2 PDB 4gop chain B Region: 26 - 106 Aligned: 70 Modelled: 81 Confidence: 96.8% Identity: 19% PDB header:dna binding protein/dna Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: structure and conformational change of a replication protein a2 heterotrimer bound to ssdna Phyre2 PDB 6i52 chain B Region: 9 - 128 Aligned: 111 Modelled: 116 Confidence: 96.7% Identity: 17% PDB header:dna binding protein Chain: B: PDB Molecule:replication factor a protein 2; PDBTitle: yeast rpa bound to ssdna Phyre2 PDB 4joi chain A Region: 26 - 125 Aligned: 96 Modelled: 98 Confidence: 96.5% Identity: 16% PDB header:dna binding protein Chain: A: PDB Molecule:cst complex subunit stn1; PDBTitle: crystal structure of the human telomeric stn1-ten1 complex Phyre2 PDB 1l0w chain A domain 1 Region: 27 - 105 Aligned: 76 Modelled: 79 Confidence: 96.1% Identity: 20% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Anticodon-binding domain Phyre2 PDB 1c0a chain A domain 1 Region: 27 - 105 Aligned: 77 Modelled: 79 Confidence: 96.0% Identity: 17% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Anticodon-binding domain Phyre2 PDB 3zdr chain A Region: 128 - 236 Aligned: 98 Modelled: 109 Confidence: 96.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:alcohol dehydrogenase domain of the bifunctional PDBTitle: structure of the alcohol dehydrogenase (adh) domain of a2 bifunctional adhe dehydrogenase from geobacillus3 thermoglucosidasius ncimb 11955 Phyre2 PDB 3bfj chain K Region: 141 - 236 Aligned: 83 Modelled: 96 Confidence: 95.9% Identity: 24% PDB header:oxidoreductase Chain: K: PDB Molecule:1,3-propanediol oxidoreductase; PDBTitle: crystal structure analysis of 1,3-propanediol oxidoreductase Phyre2 PDB 1vlj chain A Region: 141 - 236 Aligned: 83 Modelled: 96 Confidence: 95.8% Identity: 27% Fold: Dehydroquinate synthase-like Superfamily: Dehydroquinate synthase-like Family: Iron-containing alcohol dehydrogenase Phyre2 PDB 3ox4 chain D Region: 142 - 236 Aligned: 82 Modelled: 95 Confidence: 95.5% Identity: 26% PDB header:oxidoreductase Chain: D: PDB Molecule:alcohol dehydrogenase 2; PDBTitle: structures of iron-dependent alcohol dehydrogenase 2 from zymomonas2 mobilis zm4 complexed with nad cofactor Phyre2 PDB 5gro chain A Region: 27 - 105 Aligned: 76 Modelled: 77 Confidence: 95.4% Identity: 22% PDB header:ligase Chain: A: PDB Molecule:aspartate--trna(asp/asn) ligase; PDBTitle: crystal structure of the n-terminal anticodon-binding domain of non-2 discriminating aspartyl-trna synthetase from helicobacter pylori Phyre2 PDB 1e1o chain A domain 1 Region: 27 - 105 Aligned: 76 Modelled: 79 Confidence: 95.4% Identity: 24% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Anticodon-binding domain Phyre2 PDB 3okf chain A Region: 137 - 236 Aligned: 93 Modelled: 100 Confidence: 95.3% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:3-dehydroquinate synthase; PDBTitle: 2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase2 (arob) from vibrio cholerae Phyre2 PDB 1n9w chain A domain 1 Region: 27 - 105 Aligned: 69 Modelled: 79 Confidence: 95.3% Identity: 17% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Anticodon-binding domain Phyre2 PDB 1oj7 chain A Region: 142 - 236 Aligned: 84 Modelled: 95 Confidence: 95.2% Identity: 24% Fold: Dehydroquinate synthase-like Superfamily: Dehydroquinate synthase-like Family: Iron-containing alcohol dehydrogenase Phyre2 PDB 5fkv chain A Region: 27 - 106 Aligned: 78 Modelled: 80 Confidence: 95.2% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:dna polymerase iii subunit alpha; PDBTitle: cryo-em structure of the e. coli replicative dna polymerase complex2 bound to dna (dna polymerase iii alpha, beta, epsilon, tau complex) Phyre2 PDB 1gm5 chain A domain 2 Region: 27 - 106 Aligned: 78 Modelled: 80 Confidence: 95.0% Identity: 18% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: RecG "wedge" domain Phyre2 PDB 3fdu chain F Region: 185 - 238 Aligned: 54 Modelled: 54 Confidence: 94.8% Identity: 30% PDB header:isomerase Chain: F: PDB Molecule:putative enoyl-coa hydratase/isomerase; PDBTitle: crystal structure of a putative enoyl-coa hydratase/isomerase from2 acinetobacter baumannii Phyre2 PDB 1rrm chain A Region: 142 - 236 Aligned: 82 Modelled: 95 Confidence: 94.7% Identity: 26% Fold: Dehydroquinate synthase-like Superfamily: Dehydroquinate synthase-like Family: Iron-containing alcohol dehydrogenase Phyre2 1 c3f2cA_ 2 c3kf6A_ 3 c4gopB_ 4 c6i52B_ 5 c4joiA_ 6 d1l0wa1 7 d1c0aa1 8 c3zdrA_ 9 c3bfjK_ 10 d1vlja_ 11 c3ox4D_ 12 c5groA_ 13 d1e1oa1 14 c3okfA_ 15 d1n9wa1 16 d1oj7a_ 17 c5fkvA_ 18 d1gm5a2 19 c3fduF_ 20 d1rrma_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499