1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	I	L	V	D	T	S	V	W	I	E	H	L	R	A	A	D	A	R	L	V	E	L	L	G	D	D	E	A	G	C	H	P	L	V	I	E	E	L	A	L	G	S	I	K	Q	R	D	V	V	L	D	L	L	A	N	L	Y	Q	F
Secondary structure
SS confidence
Disorder		?				?	?									?	?	?																								?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	V	V	T	H	D	E	V	L	R	L	V	G	R	R	R	L	W	G	R	G	L	G	A	V	D	A	N	L	L	G	S	V	A	L	V	G	G	A	R	L	W	T	R	D	K	R	L	K	A	A	C	A	E	S	G	V	A	L	A
Secondary structure
SS confidence
Disorder				?										?	?	?	?	?	?	?																	?																			?	?	?	?	?	?
Disorder confidence
		.	.	.	.
Sequence		E	E	V	S
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 69%) Beta strand ( 4%)

Rank Aligned region

PDB 3h87 chain B Region: 2 - 119 Aligned: 117 Modelled: 118 Confidence: 99.9% Identity: 19% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 5sv2 chain A Region: 2 - 118 Aligned: 116 Modelled: 117 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 1v96 chain A domain 1 Region: 2 - 119 Aligned: 116 Modelled: 118 Confidence: 99.9% Identity: 15% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 4chg chain C Region: 2 - 119 Aligned: 118 Modelled: 117 Confidence: 99.9% Identity: 23% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 6a7v chain G Region: 2 - 119 Aligned: 118 Modelled: 118 Confidence: 99.9% Identity: 22% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 3zvk chain C Region: 1 - 119 Aligned: 115 Modelled: 119 Confidence: 99.9% Identity: 23% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 6nkl chain A Region: 1 - 111 Aligned: 110 Modelled: 111 Confidence: 99.8% Identity: 18% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 3dbo chain B Region: 2 - 119 Aligned: 110 Modelled: 118 Confidence: 99.8% Identity: 25% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 2h1c chain A domain 1 Region: 1 - 110 Aligned: 109 Modelled: 110 Confidence: 99.8% Identity: 23% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3tnd chain C Region: 2 - 111 Aligned: 109 Modelled: 110 Confidence: 99.8% Identity: 17% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 5l6m chain C Region: 2 - 119 Aligned: 114 Modelled: 118 Confidence: 99.8% Identity: 16% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 1y82 chain A domain 1 Region: 2 - 119 Aligned: 118 Modelled: 118 Confidence: 99.8% Identity: 12% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 4xgr chain G Region: 1 - 110 Aligned: 109 Modelled: 108 Confidence: 99.8% Identity: 17% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 5x3t chain D Region: 2 - 111 Aligned: 109 Modelled: 109 Confidence: 99.6% Identity: 17% PDB header:antitoxin/toxin Chain: D: PDB Molecule:ribonuclease vapc26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 5wzf chain B Region: 2 - 111 Aligned: 109 Modelled: 110 Confidence: 99.6% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:23s rrna-specific endonuclease vapc20; PDBTitle: crystal structure of mycobacterium tuberculosis vapc20 (rv2549c),2 sarcin-ricin loop cleaving toxin Phyre2 PDB 2fe1 chain A Region: 2 - 115 Aligned: 113 Modelled: 114 Confidence: 99.5% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 2fe1 chain A domain 1 Region: 2 - 115 Aligned: 113 Modelled: 114 Confidence: 99.5% Identity: 17% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3i8o chain A Region: 2 - 119 Aligned: 116 Modelled: 118 Confidence: 99.1% Identity: 19% PDB header:rna binding protein Chain: A: PDB Molecule:kh domain-containing protein mj1533; PDBTitle: a domain of a functionally unknown protein from methanocaldococcus2 jannaschii dsm 2661. Phyre2 PDB 3ix7 chain A Region: 2 - 119 Aligned: 102 Modelled: 117 Confidence: 98.9% Identity: 24% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ttha0540; PDBTitle: crystal structure of a domain of functionally unknown protein from2 thermus thermophilus hb8 Phyre2 PDB 5yww chain A Region: 2 - 119 Aligned: 112 Modelled: 118 Confidence: 98.7% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:nucleotide binding protein pinc; PDBTitle: archael ruvb-like holiday junction helicase Phyre2 1 c3h87B_ 2 c5sv2A_ 3 d1v96a1 4 c4chgC_ 5 c6a7vG_ 6 c3zvkC_ 7 c6nklA_ 8 c3dboB_ 9 d2h1ca1 10 c3tndC_ 11 c5l6mC_ 12 d1y82a1 13 c4xgrG_ 14 c5x3tD_ 15 c5wzfB_ 16 c2fe1A_ 17 d2fe1a1 18 c3i8oA_ 19 c3ix7A_ 20 c5ywwA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46