1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.
Sequence		M	T	A	R	V	A	G	Q	A	V	G	G	Q	I	L	V	G	E	P	V	H	D	A	V	S	D	C	A	D	I	R	F	G	S	Y	R	L	F	S	L	D	A	A	P	G	P	D	L	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																				?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 29%) Alpha helix ( 20%) Beta strand ( 35%)

Rank Aligned region

PDB 1y10 chain C Region: 1 - 46 Aligned: 46 Modelled: 46 Confidence: 62.6% Identity: 26% PDB header:lyase Chain: C: PDB Molecule:hypothetical protein rv1264/mt1302; PDBTitle: mycobacterial adenylyl cyclase rv1264, holoenzyme, inhibited state Phyre2 PDB 1fx4 chain A Region: 1 - 47 Aligned: 47 Modelled: 47 Confidence: 57.9% Identity: 30% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 3et6 chain A Region: 1 - 40 Aligned: 40 Modelled: 40 Confidence: 57.3% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:soluble guanylyl cyclase beta; PDBTitle: the crystal structure of the catalytic domain of a eukaryotic2 guanylate cyclase Phyre2 PDB 1fx2 chain A Region: 1 - 46 Aligned: 46 Modelled: 46 Confidence: 53.2% Identity: 28% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 4wp3 chain E Region: 1 - 46 Aligned: 43 Modelled: 46 Confidence: 52.6% Identity: 53% PDB header:lyase Chain: E: PDB Molecule:ma1120; PDBTitle: crystal structure of adenylyl cyclase from mycobacterium avium ma11202 wild type Phyre2 PDB 3mr7 chain B Region: 1 - 46 Aligned: 46 Modelled: 46 Confidence: 48.1% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi Phyre2 PDB 3r5g chain B Region: 3 - 46 Aligned: 42 Modelled: 44 Confidence: 45.7% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:cyab; PDBTitle: crystal structure of the adenylyl cyclase cyab from p. aeruginosa Phyre2 PDB 2wz1 chain B Region: 1 - 46 Aligned: 46 Modelled: 46 Confidence: 43.7% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:guanylate cyclase soluble subunit beta-1; PDBTitle: structure of the catalytic domain of human soluble guanylate cyclase 12 beta 3. Phyre2 PDB 5o5k chain C Region: 1 - 40 Aligned: 38 Modelled: 40 Confidence: 33.8% Identity: 13% PDB header:membrane protein Chain: C: PDB Molecule:adenylate cyclase; PDBTitle: x-ray structure of a bacterial adenylyl cyclase soluble domain Phyre2 PDB 1wc1 chain A Region: 1 - 37 Aligned: 37 Modelled: 37 Confidence: 32.2% Identity: 24% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 1azs chain A Region: 1 - 34 Aligned: 34 Modelled: 34 Confidence: 28.6% Identity: 9% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 1wc6 chain B Region: 1 - 37 Aligned: 37 Modelled: 37 Confidence: 27.6% Identity: 24% PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate Phyre2 PDB 3uvj chain C Region: 1 - 32 Aligned: 32 Modelled: 32 Confidence: 27.2% Identity: 19% PDB header:lyase Chain: C: PDB Molecule:guanylate cyclase soluble subunit alpha-3; PDBTitle: crystal structure of the catalytic domain of the heterodimeric human2 soluble guanylate cyclase 1. Phyre2 PDB 1azs chain B Region: 1 - 26 Aligned: 26 Modelled: 26 Confidence: 24.0% Identity: 19% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 1yk9 chain A Region: 1 - 32 Aligned: 32 Modelled: 32 Confidence: 20.8% Identity: 25% PDB header:lyase Chain: A: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of a mutant form of the mycobacterial2 adenylyl cyclase rv1625c Phyre2 PDB 1cjk chain A Region: 1 - 34 Aligned: 34 Modelled: 34 Confidence: 19.8% Identity: 9% PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn Phyre2 PDB 4qam chain B Region: 14 - 37 Aligned: 24 Modelled: 24 Confidence: 16.9% Identity: 17% PDB header:signaling protein Chain: B: PDB Molecule:x-linked retinitis pigmentosa gtpase regulator-interacting PDBTitle: crystal structure of the rpgr rcc1-like domain in complex with the2 rpgr-interacting domain of rpgrip1 Phyre2 PDB 2w01 chain C Region: 3 - 46 Aligned: 42 Modelled: 44 Confidence: 13.4% Identity: 21% PDB header:lyase Chain: C: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of the guanylyl cyclase cya2 Phyre2 PDB 6fht chain B Region: 1 - 46 Aligned: 44 Modelled: 46 Confidence: 13.1% Identity: 23% PDB header:lyase Chain: B: PDB Molecule:bacteriophytochrome,adenylate cyclase; PDBTitle: crystal structure of an artificial phytochrome regulated2 adenylate/guanylate cyclase in its dark adapted pr form Phyre2 PDB 2a45 chain L Region: 29 - 35 Aligned: 7 Modelled: 7 Confidence: 11.3% Identity: 86% PDB header:hydrolase/hydrolase inhibitor Chain: L: PDB Molecule:fibrinogen gamma chain; PDBTitle: crystal structure of the complex between thrombin and the central "e"2 region of fibrin Phyre2 1 c1y10C_ 2 d1fx4a_ 3 c3et6A_ 4 d1fx2a_ 5 c4wp3E_ 6 c3mr7B_ 7 c3r5gB_ 8 c2wz1B_ 9 c5o5kC_ 10 d1wc1a_ 11 d1azsa_ 12 c1wc6B_ 13 c3uvjC_ 14 d1azsb_ 15 c1yk9A_ 16 c1cjkA_ 17 c4qamB_ 18 c2w01C_ 19 c6fhtB_ 20 c2a45L_ 21 22 23 24 25 26 27 28 29