1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	S	G	G	R	E	A	V	K	T	V	W	Q	T	A	N	L	V	R	K	E	G	F	G	A	A	V	R	S	S	I	E	D	P	A	D	W	A	E	V	E	R	P	D	L	A	R	V	T	P	D	G	R	V	V	I	L	F	S
Secondary structure
SS confidence
Disorder		?	?	?												?										?					?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	I	E	E	S	T	A	L	D	E	R	I	G	D	R	T	W	V	K	L	I	G	A	H	D	K	L	V	H	E	L	V	R	R	W	S	G	H	M	V	T	S	Q	G	D	G	F	M	I	A	F	A	R	A	E	Q	A	V	R	C
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.
Sequence		G	I	D	I	Q	D	A	L	R	N	S	A	K	R	K	R	N	Q	G	I	R	V	R	I	G	T	T	W	G	A	R	C	G	T	V	T	I	C	S	A	A	T	S	Q
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?																	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 53%) Beta strand ( 21%)

Rank Aligned region

PDB 6fht chain B Region: 8 - 164 Aligned: 149 Modelled: 157 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: B: PDB Molecule:bacteriophytochrome,adenylate cyclase; PDBTitle: crystal structure of an artificial phytochrome regulated2 adenylate/guanylate cyclase in its dark adapted pr form Phyre2 PDB 5nby chain A Region: 7 - 164 Aligned: 149 Modelled: 158 Confidence: 100.0% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:beta subunit of photoactivated adenylyl cyclase; PDBTitle: structure of a bacterial light-regulated adenylyl cylcase Phyre2 PDB 4yus chain A Region: 7 - 164 Aligned: 149 Modelled: 158 Confidence: 100.0% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:family 3 adenylate cyclase; PDBTitle: crystal structure of photoactivated adenylyl cyclase of a2 cyanobacteriaoscillatoria acuminata in hexagonal form Phyre2 PDB 6r4o chain A Region: 6 - 164 Aligned: 154 Modelled: 159 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:adenylate cyclase 9; PDBTitle: structure of a truncated adenylyl cyclase bound to mant-gtp, forskolin2 and an activated stimulatory galphas protein Phyre2 PDB 6r4p chain A Region: 7 - 164 Aligned: 153 Modelled: 158 Confidence: 99.9% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:adenylate cyclase 9; PDBTitle: structure of a soluble domain of adenylyl cyclase bound to an2 activated stimulatory g protein Phyre2 PDB 1y10 chain C Region: 6 - 151 Aligned: 140 Modelled: 146 Confidence: 99.9% Identity: 14% PDB header:lyase Chain: C: PDB Molecule:hypothetical protein rv1264/mt1302; PDBTitle: mycobacterial adenylyl cyclase rv1264, holoenzyme, inhibited state Phyre2 PDB 1fx2 chain A Region: 43 - 164 Aligned: 117 Modelled: 122 Confidence: 99.9% Identity: 31% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 1fx4 chain A Region: 43 - 164 Aligned: 117 Modelled: 122 Confidence: 99.9% Identity: 30% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 4cll chain A Region: 28 - 156 Aligned: 117 Modelled: 129 Confidence: 99.9% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:adenylate cyclase type 10; PDBTitle: crystal structure of human soluble adenylyl cyclase in complex with2 bicarbonate Phyre2 PDB 5o5k chain C Region: 9 - 164 Aligned: 143 Modelled: 155 Confidence: 99.9% Identity: 15% PDB header:membrane protein Chain: C: PDB Molecule:adenylate cyclase; PDBTitle: x-ray structure of a bacterial adenylyl cyclase soluble domain Phyre2 PDB 1cjk chain A Region: 51 - 156 Aligned: 105 Modelled: 106 Confidence: 99.9% Identity: 21% PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn Phyre2 PDB 4wp3 chain E Region: 28 - 151 Aligned: 109 Modelled: 124 Confidence: 99.9% Identity: 76% PDB header:lyase Chain: E: PDB Molecule:ma1120; PDBTitle: crystal structure of adenylyl cyclase from mycobacterium avium ma11202 wild type Phyre2 PDB 1wc6 chain B Region: 50 - 164 Aligned: 111 Modelled: 115 Confidence: 99.9% Identity: 21% PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate Phyre2 PDB 1wc1 chain A Region: 50 - 155 Aligned: 106 Modelled: 106 Confidence: 99.9% Identity: 24% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 1azs chain A Region: 52 - 164 Aligned: 108 Modelled: 113 Confidence: 99.9% Identity: 20% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 3mr7 chain B Region: 50 - 154 Aligned: 105 Modelled: 105 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi Phyre2 PDB 3uvj chain C Region: 54 - 156 Aligned: 102 Modelled: 103 Confidence: 99.8% Identity: 21% PDB header:lyase Chain: C: PDB Molecule:guanylate cyclase soluble subunit alpha-3; PDBTitle: crystal structure of the catalytic domain of the heterodimeric human2 soluble guanylate cyclase 1. Phyre2 PDB 3r5g chain B Region: 50 - 156 Aligned: 107 Modelled: 107 Confidence: 99.8% Identity: 22% PDB header:lyase Chain: B: PDB Molecule:cyab; PDBTitle: crystal structure of the adenylyl cyclase cyab from p. aeruginosa Phyre2 PDB 2w01 chain C Region: 50 - 164 Aligned: 111 Modelled: 115 Confidence: 99.8% Identity: 24% PDB header:lyase Chain: C: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of the guanylyl cyclase cya2 Phyre2 PDB 1ybu chain A Region: 50 - 154 Aligned: 98 Modelled: 105 Confidence: 99.8% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:lipj; PDBTitle: mycobacterium tuberculosis adenylyl cyclase rv1900c chd, in complex2 with a substrate analog. Phyre2 1 c6fhtB_ 2 c5nbyA_ 3 c4yusA_ 4 c6r4oA_ 5 c6r4pA_ 6 c1y10C_ 7 d1fx2a_ 8 d1fx4a_ 9 c4cllA_ 10 c5o5kC_ 11 c1cjkA_ 12 c4wp3E_ 13 c1wc6B_ 14 d1wc1a_ 15 d1azsa_ 16 c3mr7B_ 17 c3uvjC_ 18 c3r5gB_ 19 c2w01C_ 20 c1ybuA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95