1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	V	D	G	G	G	G	A	S	D	L	L	V	I	F	G	I	T	G	D	L	A	R	K	M	T	F	R	A	L	Y	R	L	E	R	H	Q	L	L	D	C	P	I	L	G	V	A	S	D	D	M	S	V	G	Q	L	V	K	W	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	E	S	I	G	R	T	E	K	I	D	D	A	V	F	D	R	L	A	G	R	L	S	Y	L	H	G	D	V	T	D	S	Q	L	Y	D	S	L	A	E	L	I	G	S	A	C	R	P	L	Y	Y	L	E	M	P	P	A	L	F	A
Secondary structure
SS confidence
Disorder							?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	I	V	E	N	L	A	N	V	R	L	L	E	R	A	R	V	A	V	E	K	P	F	G	H	D	L	A	S	A	L	E	L	N	A	R	L	R	A	V	L	G	E	D	Q	I	L	R	V	D	H	F	L	G	K	Q	P	V	V	E
Secondary structure
SS confidence
Disorder												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	E	Y	L	R	F	A	N	Q	A	L	A	E	L	W	D	R	N	S	I	S	E	I	H	I	T	M	A	E	D	F	G	V	E	D	R	G	K	F	Y	D	A	V	G	A	L	R	D	V	V	Q	N	H	L	L	Q	V	L	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	T	M	E	P	P	V	G	S	S	A	D	D	L	N	D	K	K	A	E	V	F	R	A	M	A	P	L	D	P	D	R	C	V	R	G	Q	Y	L	G	Y	T	E	V	A	G	V	A	S	D	S	A	T	E	T	Y	V	A	L	R
Secondary structure
SS confidence
Disorder										?																														?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	E	I	D	N	W	R	W	A	G	V	P	I	F	V	R	A	G	K	E	L	P	A	K	V	T	E	V	R	L	F	L	R	R	V	P	A	L	A	F	L	P	N	R	R	P	A	E	P	N	Q	I	V	L	R	I	D	P	D	P
Secondary structure
SS confidence
Disorder																																												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	M	R	L	Q	I	S	A	H	T	D	D	S	W	R	D	I	H	L	D	S	S	F	A	V	D	L	G	E	P	I	R	P	Y	E	R	L	L	Y	A	G	L	V	G	D	H	Q	L	F	A	R	E	D	S	I	E	Q	T	W	R
Secondary structure
SS confidence
Disorder														?	?												?	?	?	?	?	?																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.
Sequence		I	V	Q	P	L	L	D	N	P	G	E	I	H	R	Y	D	R	G	S	W	G	P	E	A	A	Q	S	L	L	R	G	H	R	G	W	Q	S	P	W	L	P	R	G	T	D	A
Secondary structure
SS confidence
Disorder																		?			?																					?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 40%) Beta strand ( 17%)

Rank Aligned region

PDB 4lgv chain A Region: 8 - 462 Aligned: 455 Modelled: 455 Confidence: 100.0% Identity: 80% PDB header:oxidoreductase Chain: A: PDB Molecule:glucose-6-phosphate 1-dehydrogenase; PDBTitle: x-ray crystal structure of glucose-6-phosphate 1-dehydrogenase from2 mycobacterium avium Phyre2 PDB 2bhl chain B Region: 6 - 456 Aligned: 447 Modelled: 451 Confidence: 100.0% Identity: 33% PDB header:oxidoreductase Chain: B: PDB Molecule:glucose-6-phosphate 1-dehydrogenase; PDBTitle: x-ray structure of human glucose-6-phosphate dehydrogenase (deletion2 variant) complexed with glucose-6-phosphate Phyre2 PDB 1h9a chain A Region: 7 - 458 Aligned: 449 Modelled: 452 Confidence: 100.0% Identity: 31% PDB header:oxidoreductase (choh(d) - nad(p)) Chain: A: PDB Molecule:glucose 6-phosphate 1-dehydrogenase; PDBTitle: complex of active mutant (q365->c) of glucose 6-phosphate2 dehydrogenase from l. mesenteroides with coenzyme nadp Phyre2 PDB 1qki chain E Region: 7 - 457 Aligned: 447 Modelled: 451 Confidence: 100.0% Identity: 33% PDB header:oxidoreductase Chain: E: PDB Molecule:glucose-6-phosphate 1-dehydrogenase; PDBTitle: x-ray structure of human glucose 6-phosphate dehydrogenase (variant2 canton r459l) complexed with structural nadp+ Phyre2 PDB 4e9i chain B Region: 6 - 455 Aligned: 446 Modelled: 450 Confidence: 100.0% Identity: 34% PDB header:oxidoreductase Chain: B: PDB Molecule:glucose-6-phosphate 1-dehydrogenase; PDBTitle: glucose-6-p dehydrogenase (apo form) from trypanosoma cruzi Phyre2 PDB 1qki chain A domain 2 Region: 170 - 461 Aligned: 276 Modelled: 292 Confidence: 100.0% Identity: 35% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: Glucose 6-phosphate dehydrogenase-like Phyre2 PDB 1h9a chain A domain 2 Region: 175 - 458 Aligned: 272 Modelled: 274 Confidence: 100.0% Identity: 29% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: Glucose 6-phosphate dehydrogenase-like Phyre2 PDB 1h9a chain A domain 1 Region: 7 - 188 Aligned: 181 Modelled: 182 Confidence: 100.0% Identity: 28% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1qki chain A domain 1 Region: 2 - 183 Aligned: 179 Modelled: 181 Confidence: 100.0% Identity: 28% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 5yab chain D Region: 9 - 427 Aligned: 345 Modelled: 365 Confidence: 97.9% Identity: 13% PDB header:oxidoreductase Chain: D: PDB Molecule:scyllo-inositol dehydrogenase with l-glucose dehydrogenase PDBTitle: crystal structure of scyllo-inositol dehydrogenase with l-glucose2 dehydrogenase activity Phyre2 PDB 3kux chain A Region: 5 - 248 Aligned: 189 Modelled: 206 Confidence: 97.5% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:putative oxidoreductase; PDBTitle: structure of the ypo2259 putative oxidoreductase from yersinia pestis Phyre2 PDB 3btu chain D Region: 8 - 251 Aligned: 199 Modelled: 214 Confidence: 97.4% Identity: 16% PDB header:transcription Chain: D: PDB Molecule:galactose/lactose metabolism regulatory protein PDBTitle: crystal structure of the super-repressor mutant of gal80p2 from saccharomyces cerevisiae; gal80(s2) [e351k] Phyre2 PDB 3u3x chain J Region: 38 - 246 Aligned: 188 Modelled: 209 Confidence: 97.3% Identity: 17% PDB header:oxidoreductase Chain: J: PDB Molecule:oxidoreductase; PDBTitle: crystal structure of a putative oxidoreductase from sinorhizobium2 meliloti 1021 Phyre2 PDB 5uib chain A Region: 8 - 242 Aligned: 185 Modelled: 214 Confidence: 97.3% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:oxidoreductase protein; PDBTitle: crystal structure of an oxidoreductase from agrobacterium radiobacter2 in complex with nad+, l-tartaric acid and magnesium Phyre2 PDB 3e18 chain A Region: 8 - 427 Aligned: 332 Modelled: 351 Confidence: 97.2% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:oxidoreductase; PDBTitle: crystal structure of nad-binding protein from listeria innocua Phyre2 PDB 5b3u chain B Region: 7 - 160 Aligned: 114 Modelled: 133 Confidence: 97.2% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:biliverdin reductase; PDBTitle: crystal structure of biliverdin reductase in complex with nadp+ from2 synechocystis sp. pcc 6803 Phyre2 PDB 3euw chain B Region: 9 - 160 Aligned: 112 Modelled: 131 Confidence: 97.1% Identity: 13% PDB header:oxidoreductase Chain: B: PDB Molecule:myo-inositol dehydrogenase; PDBTitle: crystal structure of a myo-inositol dehydrogenase from corynebacterium2 glutamicum atcc 13032 Phyre2 PDB 3rbv chain A Region: 8 - 160 Aligned: 114 Modelled: 132 Confidence: 97.1% Identity: 21% PDB header:sugar binding protein Chain: A: PDB Molecule:sugar 3-ketoreductase; PDBTitle: crystal structure of kijd10, a 3-ketoreductase from actinomadura2 kijaniata incomplex with nadp Phyre2 PDB 3db2 chain C Region: 8 - 160 Aligned: 113 Modelled: 132 Confidence: 97.1% Identity: 17% PDB header:oxidoreductase Chain: C: PDB Molecule:putative nadph-dependent oxidoreductase; PDBTitle: crystal structure of a putative nadph-dependent oxidoreductase2 (dhaf_2064) from desulfitobacterium hafniense dcb-2 at 1.70 a3 resolution Phyre2 PDB 4hkt chain A Region: 9 - 160 Aligned: 111 Modelled: 131 Confidence: 97.1% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:inositol 2-dehydrogenase; PDBTitle: crystal structure of a putative myo-inositol dehydrogenase from2 sinorhizobium meliloti 1021 (target psi-012312) Phyre2 1 c4lgvA_ 2 c2bhlB_ 3 c1h9aA_ 4 c1qkiE_ 5 c4e9iB_ 6 d1qkia2 7 d1h9aa2 8 d1h9aa1 9 d1qkia1 10 c5yabD_ 11 c3kuxA_ 12 c3btuD_ 13 c3u3xJ_ 14 c5uibA_ 15 c3e18A_ 16 c5b3uB_ 17 c3euwB_ 18 c3rbvA_ 19 c3db2C_ 20 c4hktA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185