1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	F	L	Q	P	R	L	P	D	I	D	L	A	E	W	S	Q	G	S	R	S	Q	K	I	R	P	M	A	Q	H	W	A	E	V	G	F	G	T	P	V	L	L	H	L	F	Y	V	A	K	I	L	L	Y	V	L	V	G	W	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?										?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	V	L	T	T	K	G	I	D	G	F	T	D	A	A	A	W	Y	A	E	P	I	V	F	E	K	V	V	L	Y	T	M	L	F	E	V	I	G	L	G	C	G	F	G	P	L	N	N	R	F	F	P	P	M	G	S	I	L	Y	W
Secondary structure
SS confidence
Disorder							?	?	?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	R	F	G	T	I	R	L	P	P	W	P	D	R	V	P	W	T	R	G	T	K	R	K	P	V	D	V	A	L	Y	A	L	L	V	M	M	L	L	S	A	L	F	T	D	G	A	G	P	I	P	E	L	G	T	T	V	G	L	L
Secondary structure
SS confidence
Disorder																			?																										?	?	?	?	?	?	?	?	?	?	?	?		?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	A	W	Q	I	V	L	I	L	L	L	L	G	V	L	G	L	R	D	K	V	I	F	L	A	A	R	G	E	V	Y	A	T	L	T	V	T	F	L	F	G	R	L	N	G	I	D	M	I	V	A	A	K	L	V	F	L	V	I	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	G	A	A	T	S	K	L	N	R	H	F	P	F	V	I	S	T	M	M	S	N	N	P	L	F	R	P	R	F	I	K	R	M	F	F	K	K	F	P	G	D	L	R	P	G	L	L	S	R	I	V	A	H	V	S	T	V	I	E
Secondary structure
SS confidence
Disorder																				?	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		M	C	V	P	V	V	L	F	V	A	H	G	G	W	P	T	V	V	A	A	T	I	M	V	C	F	H	L	G	I	L	T	A	I	P	M	G	V	P	L	E	W	N	V	F	M	I	F	G	V	L	S	L	F	V	G	H	A	C	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	L	A	D	V	K	N	P	V	P	L	A	I	L	I	A	V	V	A	G	I	V	I	A	G	N	V	F	P	R	K	I	S	F	L	A	A	M	R	Y	Y	A	G	N	W	D	T	T	L	W	C	I	K	P	S	A	E	D	K	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		N	R	G	I	V	A	I	A	S	M	P	A	A	Q	L	E	R	F	Y	G	K	D	R	A	Q	I	P	M	Y	L	G	Y	A	F	R	A	M	N	S	H	G	R	A	L	F	T	L	A	H	R	A	M	A	G	H	D	E	D	D	Y
Secondary structure
SS confidence
Disorder							?	?	?	?	?																																?	?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		V	I	T	D	G	E	R	V	C	S	T	A	V	G	W	N	F	G	D	G	H	L	H	N	E	Q	L	I	A	A	M	Q	Q	R	C	G	F	Q	P	G	E	V	R	V	V	L	L	D	A	Q	P	I	H	R	Q	T	Q	E	Y	R
Secondary structure
SS confidence
Disorder									?	?																											?														?	?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.
Sequence		L	V	D	A	A	T	G	E	F	E	R	G	Y	V	R	V	A	D	M	V	N	R	Q	P	W	D	D	D	V	P	V	H	V	L	P	G
Secondary structure
SS confidence
Disorder												?											?	?	?									?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 62%) Beta strand ( 4%) TM helix ( 34%) (View membrane topology prediction)

Rank Aligned region

PDB 2r6g chain F domain 1 Region: 496 - 565 Aligned: 66 Modelled: 70 Confidence: 56.9% Identity: 15% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 3hi2 chain C Region: 436 - 456 Aligned: 21 Modelled: 21 Confidence: 38.8% Identity: 33% PDB header:dna binding protein/toxin Chain: C: PDB Molecule:hth-type transcriptional regulator mqsa(ygit); PDBTitle: structure of the n-terminal domain of the e. coli antitoxin mqsa2 (ygit/b3021) in complex with the e. coli toxin mqsr (ygiu/b3022) Phyre2 PDB 1fo1 chain A domain 2 Region: 505 - 522 Aligned: 17 Modelled: 18 Confidence: 37.6% Identity: 35% Fold: Ferredoxin-like Superfamily: RNA-binding domain, RBD Family: Non-canonical RBD domain Phyre2 PDB 4gvs chain A Region: 469 - 537 Aligned: 68 Modelled: 69 Confidence: 34.6% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:methenyltetrahydromethanopterin cyclohydrolase; PDBTitle: x-ray structure of the archaeoglobus fulgidus methenyl-2 tetrahydromethanopterin cyclohydrolase in complex with n5-formyl-3 tetrahydromethanopterin Phyre2 PDB 1qlm chain A Region: 469 - 537 Aligned: 68 Modelled: 69 Confidence: 33.8% Identity: 21% Fold: Methenyltetrahydromethanopterin cyclohydrolase Superfamily: Methenyltetrahydromethanopterin cyclohydrolase Family: Methenyltetrahydromethanopterin cyclohydrolase Phyre2 PDB 2hjj chain A Region: 409 - 424 Aligned: 16 Modelled: 16 Confidence: 32.8% Identity: 38% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ykff; PDBTitle: solution nmr structure of protein ykff from escherichia coli.2 northeast structural genomics target er397. Phyre2 PDB 2hjj chain A domain 1 Region: 409 - 424 Aligned: 16 Modelled: 16 Confidence: 32.8% Identity: 38% Fold: dsRBD-like Superfamily: YcfA/nrd intein domain Family: YkfF-like Phyre2 PDB 1b4r chain A Region: 495 - 500 Aligned: 6 Modelled: 6 Confidence: 26.8% Identity: 83% Fold: Immunoglobulin-like beta-sandwich Superfamily: PKD domain Family: PKD domain Phyre2 PDB 4fio chain A Region: 469 - 537 Aligned: 68 Modelled: 69 Confidence: 25.5% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:methenyltetrahydromethanopterin cyclohydrolase; PDBTitle: crystal structure of methenyltetrahydromethanopterin cyclohydrolase2 from methanobrevibacter ruminantium Phyre2 PDB 1vkw chain A Region: 559 - 573 Aligned: 15 Modelled: 15 Confidence: 24.9% Identity: 33% Fold: FMN-dependent nitroreductase-like Superfamily: FMN-dependent nitroreductase-like Family: Putative nitroreductase TM1586 Phyre2 PDB 3iac chain A Region: 452 - 516 Aligned: 60 Modelled: 65 Confidence: 24.8% Identity: 23% PDB header:isomerase Chain: A: PDB Molecule:glucuronate isomerase; PDBTitle: 2.2 angstrom crystal structure of glucuronate isomerase from2 salmonella typhimurium. Phyre2 PDB 2l6p chain A Region: 475 - 501 Aligned: 27 Modelled: 27 Confidence: 21.7% Identity: 22% PDB header:structure genomics, unknown function Chain: A: PDB Molecule:phac1, phac2 and phad genes; PDBTitle: nmr solution structure of the protein np_253742.1 Phyre2 PDB 1j2j chain B Region: 267 - 284 Aligned: 18 Modelled: 18 Confidence: 20.1% Identity: 28% Fold: Spectrin repeat-like Superfamily: GAT-like domain Family: GAT domain Phyre2 PDB 1wgo chain A Region: 495 - 500 Aligned: 6 Modelled: 6 Confidence: 19.7% Identity: 50% Fold: Immunoglobulin-like beta-sandwich Superfamily: PKD domain Family: PKD domain Phyre2 PDB 5jpq chain I Region: 274 - 284 Aligned: 11 Modelled: 11 Confidence: 19.2% Identity: 36% PDB header:ribosome Chain: I: PDB Molecule:u3 small nucleolar rna-associated protein 21; PDBTitle: cryo-em structure of the 90s pre-ribosome Phyre2 PDB 6rdf chain 7 Region: 272 - 284 Aligned: 13 Modelled: 13 Confidence: 18.3% Identity: 31% PDB header:proton transport Chain: 7: PDB Molecule:mitochondrial atp synthase associated protein asa7; PDBTitle: cryoem structure of polytomella f-atp synthase, primary rotary state2 3, monomer-masked refinement Phyre2 PDB 2zpa chain B Region: 274 - 284 Aligned: 11 Modelled: 11 Confidence: 18.0% Identity: 36% PDB header:transferase Chain: B: PDB Molecule:uncharacterized protein ypfi; PDBTitle: crystal structure of trna(met) cytidine acetyltransferase Phyre2 PDB 1x27 chain F Region: 516 - 565 Aligned: 44 Modelled: 50 Confidence: 17.7% Identity: 23% PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas Phyre2 PDB 2l6n chain A Region: 479 - 501 Aligned: 23 Modelled: 23 Confidence: 17.6% Identity: 35% PDB header:structure genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein yp_001092504.1; PDBTitle: nmr solution structure of the protein yp_001092504.1 Phyre2 PDB 4yub chain B Region: 470 - 543 Aligned: 55 Modelled: 55 Confidence: 17.3% Identity: 15% PDB header:ligase Chain: B: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of human nicotinic acid phosphoribosyltransferase Phyre2 1 d2r6gf1 2 c3hi2C_ 3 d1fo1a2 4 c4gvsA_ 5 d1qlma_ 6 c2hjjA_ 7 d2hjja1 8 d1b4ra_ 9 c4fioA_ 10 d1vkwa_ 11 c3iacA_ 12 c2l6pA_ 13 d1j2jb_ 14 d1wgoa_ 15 c5jpqi_ 16 c6rdf7_ 17 c2zpaB_ 18 c1x27F_ 19 c2l6nA_ 20 c4yubB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99