1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	L	G	N	Q	N	T	M	R	F	A	G	R	P	Q	R	F	R	Q	S	A	Y	P	L	F	N	P	N	S	A	I	A	L	G	H	P	F	G	G	S	G	A	R	L	M	T	T	V	L	H	H	M	P	D	K	G	I	R	Y
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80
Sequence		G	L	Q	T	M	C	E	G	R	G	Q	A	N	A	T	I	V	E	L	L
Secondary structure
SS confidence
Disorder																			?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 62%) Beta strand ( 9%)

Rank Aligned region

PDB 1ulq chain A domain 2 Region: 11 - 80 Aligned: 70 Modelled: 70 Confidence: 99.8% Identity: 47% Fold: Thiolase-like Superfamily: Thiolase-like Family: Thiolase-related Phyre2 PDB 1m3k chain A domain 2 Region: 11 - 80 Aligned: 70 Modelled: 70 Confidence: 99.8% Identity: 40% Fold: Thiolase-like Superfamily: Thiolase-like Family: Thiolase-related Phyre2 PDB 1wdk chain C domain 2 Region: 14 - 80 Aligned: 67 Modelled: 67 Confidence: 99.8% Identity: 43% Fold: Thiolase-like Superfamily: Thiolase-like Family: Thiolase-related Phyre2 PDB 1afw chain A domain 2 Region: 11 - 79 Aligned: 67 Modelled: 69 Confidence: 99.7% Identity: 37% Fold: Thiolase-like Superfamily: Thiolase-like Family: Thiolase-related Phyre2 PDB 3svk chain B Region: 11 - 79 Aligned: 69 Modelled: 69 Confidence: 99.7% Identity: 35% PDB header:transferase Chain: B: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: crystal structure of acetyl-coa acetyltransferase from mycobacterium2 avium Phyre2 PDB 1ulq chain D Region: 20 - 80 Aligned: 61 Modelled: 61 Confidence: 99.7% Identity: 48% PDB header:transferase Chain: D: PDB Molecule:putative acetyl-coa acetyltransferase; PDBTitle: crystal structure of tt0182 from thermus thermophilus hb8 Phyre2 PDB 2d3t chain C Region: 14 - 80 Aligned: 67 Modelled: 67 Confidence: 99.7% Identity: 43% PDB header:lyase, oxidoreductase/transferase Chain: C: PDB Molecule:3-ketoacyl-coa thiolase; PDBTitle: fatty acid beta-oxidation multienzyme complex from2 pseudomonas fragi, form v Phyre2 PDB 5bz4 chain K Region: 14 - 80 Aligned: 67 Modelled: 66 Confidence: 99.7% Identity: 37% PDB header:transferase Chain: K: PDB Molecule:beta-ketothiolase; PDBTitle: crystal structure of a t1-like thiolase (coa-complex) from2 mycobacterium smegmatis Phyre2 PDB 4ubw chain B Region: 22 - 80 Aligned: 59 Modelled: 59 Confidence: 99.7% Identity: 41% PDB header:transferase Chain: B: PDB Molecule:acetyl-coa acetyltransferase fada5; PDBTitle: apo structure of the 3-ketoacyl-coa thiolase fada5 from m.2 tuberculosis Phyre2 PDB 3ss6 chain B Region: 22 - 80 Aligned: 59 Modelled: 59 Confidence: 99.6% Identity: 32% PDB header:transferase Chain: B: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: crystal structure of the bacillus anthracis acetyl-coa2 acetyltransferase Phyre2 PDB 4nzs chain A Region: 22 - 80 Aligned: 59 Modelled: 59 Confidence: 99.6% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:beta-ketothiolase bktb; PDBTitle: crystal structure of beta-ketothiolase bktb b from ralstonia eutropha2 h16 Phyre2 PDB 5xyj chain A Region: 22 - 80 Aligned: 59 Modelled: 59 Confidence: 99.6% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: purification,crystallization and structural analysis of cytoplastic2 acetoacetyl-coa thiolase from saccharomyces cerevisiae Phyre2 PDB 1wl5 chain A Region: 22 - 79 Aligned: 58 Modelled: 58 Confidence: 99.6% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:acetyl-coenzyme a acetyltransferase 2; PDBTitle: human cytosolic acetoacetyl-coa thiolase Phyre2 PDB 1afw chain B Region: 22 - 79 Aligned: 56 Modelled: 58 Confidence: 99.6% Identity: 39% PDB header:thiolase Chain: B: PDB Molecule:3-ketoacetyl-coa thiolase; PDBTitle: the 1.8 angstrom crystal structure of the dimeric2 peroxisomal thiolase of saccharomyces cerevisiae Phyre2 PDB 5zrv chain H Region: 18 - 80 Aligned: 63 Modelled: 63 Confidence: 99.6% Identity: 35% PDB header:liase, oxidoreductase/transferase Chain: H: PDB Molecule:trifunctional enzyme subunit beta, mitochondrial; PDBTitle: structure of human mitochondrial trifunctional protein, octamer Phyre2 PDB 4wys chain B Region: 22 - 80 Aligned: 59 Modelled: 59 Confidence: 99.6% Identity: 46% PDB header:transferase Chain: B: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: crystal structure of thiolase from escherichia coli Phyre2 PDB 6bja chain A Region: 22 - 80 Aligned: 57 Modelled: 59 Confidence: 99.6% Identity: 39% PDB header:transferase Chain: A: PDB Molecule:acetyl-coa acetyltransferase a; PDBTitle: crystal structure of acat5 thiolase from ascaris suum in complex with2 coenzyme a Phyre2 PDB 6aqp chain A Region: 22 - 80 Aligned: 59 Modelled: 59 Confidence: 99.6% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: aspergillus fumigatus cytosolic thiolase: acetylated enzyme in complex2 with coa and potassium ions Phyre2 PDB 2vu2 chain D Region: 22 - 80 Aligned: 59 Modelled: 59 Confidence: 99.6% Identity: 44% PDB header:transferase Chain: D: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: biosynthetic thiolase from z. ramigera. complex with s-pantetheine-11-2 pivalate. Phyre2 PDB 6bn2 chain A Region: 22 - 80 Aligned: 59 Modelled: 59 Confidence: 99.6% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: crystal structure of acetyl-coa acetyltransferase from elizabethkingia2 anophelis nuhp1 Phyre2 1 d1ulqa2 2 d1m3ka2 3 d1wdkc2 4 d1afwa2 5 c3svkB_ 6 c1ulqD_ 7 c2d3tC_ 8 c5bz4K_ 9 c4ubwB_ 10 c3ss6B_ 11 c4nzsA_ 12 c5xyjA_ 13 c1wl5A_ 14 c1afwB_ 15 c5zrvH_ 16 c4wysB_ 17 c6bjaA_ 18 c6aqpA_ 19 c2vu2D_ 20 c6bn2A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99