1

.

.

.

.

.

.

.

.

10

.

.

.

.

.

.

.

.

.

20

.

.

.

.

.

.

.

.

.

30

.

.

.

.

.

.

.

.

.

40

.

.

.

.

.

.

.

.

.

50

.

.

.

.

.

.

.

.

.

60

Sequence

V

L

S

A

R

C

H

I

R

H

I

G

S

P

G

K

D

A

R

C

A

H

L

S

A

T

L

R

P

G

I

G

I

S

P

T

N

V

G

N

A

T

V

L

A

D

G

T

P

A

K

P

I

Q

G

A

E

T

M

Q

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

.

.

.

.

.

80

.

.

.

.

.

.

.

.

.

90

.

.

.

.

.

.

.

.

.

100

.

.

.

.

.

.

.

.

.

110

.

.

.

.

.

.

.

.

.

120

Sequence

R

A

R

H

T

G

S

C

F

S

A

N

A

R

G

P

A

I

S

S

G

N

P

S

R

A

G

C

G

V

P

S

S

T

T

T

P

S

S

T

P

Q

A

I

R

L

L

A

C

T

D

S

D

A

L

T

V

T

R

T

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

Sequence

A

R

Secondary structure

SS confidence

Disorder

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 44%) Alpha helix ( 7%) Beta strand ( 32%)

Rank Aligned region

PDB 6nu4 chain A Region: 61 - 90 Aligned: 30 Modelled: 30 Confidence: 31.8% Identity: 37% PDB header:plant protein Chain: A: PDB Molecule:protein ralf-like 8; PDBTitle: solution structure of the arabidopsis thaliana ralf8 peptide Phyre2 PDB 1ewn chain A Region: 52 - 77 Aligned: 26 Modelled: 26 Confidence: 10.5% Identity: 35% Fold: FMT C-terminal domain-like Superfamily: FMT C-terminal domain-like Family: 3-methyladenine DNA glycosylase (AAG, ANPG, MPG) Phyre2 PDB 2i2x chain O Region: 15 - 25 Aligned: 11 Modelled: 11 Confidence: 8.5% Identity: 45% PDB header:transferase Chain: O: PDB Molecule:methyltransferase 1; PDBTitle: crystal structure of methanol:cobalamin methyltransferase complex2 mtabc from methanosarcina barkeri Phyre2 PDB 2fyg chain A domain 1 Region: 5 - 20 Aligned: 13 Modelled: 13 Confidence: 8.1% Identity: 54% Fold: Coronavirus NSP10-like Superfamily: Coronavirus NSP10-like Family: Coronavirus NSP10-like Phyre2 PDB 2kb8 chain A Region: 34 - 42 Aligned: 9 Modelled: 9 Confidence: 7.3% Identity: 67% PDB header:hormone Chain: A: PDB Molecule:islet amyloid polypeptide; PDBTitle: the dynamic alpha-helix structure of micelle-bound human2 amylin. Phyre2 PDB 2zdr chain A domain 1 Region: 25 - 35 Aligned: 11 Modelled: 11 Confidence: 7.3% Identity: 45% Fold: beta-clip Superfamily: AFP III-like domain Family: AFP III-like domain Phyre2 PDB 5yni chain B Region: 5 - 20 Aligned: 13 Modelled: 16 Confidence: 7.1% Identity: 46% PDB header:transferase Chain: B: PDB Molecule:nsp10 protein; PDBTitle: crystal structure of mers-cov nsp16/nsp10 complex bound to sam and2 m7gpppg Phyre2 PDB 1zbf chain A domain 1 Region: 79 - 90 Aligned: 12 Modelled: 12 Confidence: 6.0% Identity: 33% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Ribonuclease H Phyre2 PDB 2bvy chain A domain 1 Region: 8 - 32 Aligned: 25 Modelled: 25 Confidence: 6.0% Identity: 40% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: E-set domains of sugar-utilizing enzymes Phyre2 PDB 2l86 chain A Region: 34 - 42 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 67% PDB header:apoptosis Chain: A: PDB Molecule:islet amyloid polypeptide; PDBTitle: solution nmr structure of human amylin in sds micelles at ph 7.3 Phyre2 1 c6nu4A_ 2 d1ewna_ 3 c2i2xO_ 4 d2fyga1 5 c2kb8A_ 6 d2zdra1 7 c5yniB_ 8 d1zbfa1 9 d2bvya1 10 c2l86A_