1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	Y	Y	L	L	I	L	A	V	V	F	E	R	L	A	E	L	V	V	A	Q	R	N	A	R	W	S	F	A	Q	G	G	K	E	F	G	R	P	H	Y	V	V	M	V	I	L	H	T	A	L	L	L	G	C	V	V	E	P	W	A
Secondary structure
SS confidence
Disorder		?																				?	?	?						?	?				?																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	H	R	P	F	I	P	W	L	G	W	P	M	L	A	V	V	V	A	S	Q	G	L	R	W	W	C	V	K	S	L	G	K	R	W	N	T	R	V	I	V	L	P	H	A	T	L	V	R	R	G	P	Y	R	W	M	R	H	P	N
Secondary structure
SS confidence
Disorder		?			?		?	?																																			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.
Sequence		Y	V	A	V	V	A	E	G	F	A	L	P	L	V	H	T	A	W	L	T	A	L	V	F	T	L	A	N	A	T	L	L	T	V	R	L	R	V	E	N	S	V	L	G	Y	I
Secondary structure
SS confidence
Disorder																																													?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 82%) Beta strand ( 3%) TM helix ( 42%) (View membrane topology prediction)

Rank Aligned region

PDB 5v7p chain A Region: 3 - 165 Aligned: 160 Modelled: 163 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:protein-s-isoprenylcysteine o-methyltransferase; PDBTitle: atomic structure of the eukaryotic intramembrane ras methyltransferase2 icmt (isoprenylcysteine carboxyl methyltransferase), in complex with3 a monobody Phyre2 PDB 4a2n chain B Region: 2 - 165 Aligned: 164 Modelled: 164 Confidence: 99.9% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:isoprenylcysteine carboxyl methyltransferase; PDBTitle: crystal structure of ma-icmt Phyre2 PDB 4quv chain B Region: 5 - 165 Aligned: 161 Modelled: 161 Confidence: 99.6% Identity: 14% PDB header:oxidoreductase, membrane protein Chain: B: PDB Molecule:delta(14)-sterol reductase; PDBTitle: structure of an integral membrane delta(14)-sterol reductase Phyre2 PDB 1s7i chain A Region: 96 - 113 Aligned: 18 Modelled: 18 Confidence: 33.2% Identity: 17% Fold: Ferredoxin-like Superfamily: Dimeric alpha+beta barrel Family: DGPF domain (Pfam 04946) Phyre2 PDB 1p58 chain F Region: 116 - 128 Aligned: 13 Modelled: 13 Confidence: 28.3% Identity: 31% PDB header:virus Chain: F: PDB Molecule:envelope protein m; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 1p58 chain E Region: 115 - 146 Aligned: 32 Modelled: 32 Confidence: 27.3% Identity: 19% PDB header:virus Chain: E: PDB Molecule:envelope protein m; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 3j2p chain D Region: 115 - 129 Aligned: 15 Modelled: 15 Confidence: 18.8% Identity: 27% PDB header:viral protein Chain: D: PDB Molecule:small envelope protein m; PDBTitle: cryoem structure of dengue virus envelope protein heterotetramer Phyre2 PDB 5wsn chain D Region: 116 - 129 Aligned: 14 Modelled: 14 Confidence: 14.8% Identity: 29% PDB header:virus Chain: D: PDB Molecule:m protein; PDBTitle: structure of japanese encephalitis virus Phyre2 PDB 5ht7 chain A Region: 103 - 121 Aligned: 19 Modelled: 19 Confidence: 12.4% Identity: 37% PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a transition-metal-ion-binding betagamma-2 crystallin from methanosaeta thermophila Phyre2 PDB 4b03 chain D Region: 115 - 151 Aligned: 36 Modelled: 37 Confidence: 11.4% Identity: 19% PDB header:virus Chain: D: PDB Molecule:dengue virus 1 prm protein; PDBTitle: 6a electron cryomicroscopy structure of immature dengue virus serotype2 1 Phyre2 PDB 4cbf chain B Region: 115 - 129 Aligned: 15 Modelled: 15 Confidence: 10.7% Identity: 13% PDB header:virus Chain: B: PDB Molecule:m protein; PDBTitle: near-atomic resolution cryo-em structure of dengue serotype 4 virus Phyre2 PDB 5ire chain D Region: 115 - 129 Aligned: 15 Modelled: 15 Confidence: 10.7% Identity: 20% PDB header:virus Chain: D: PDB Molecule:m protein; PDBTitle: the cryo-em structure of zika virus Phyre2 PDB 6epz chain A Region: 103 - 121 Aligned: 19 Modelled: 19 Confidence: 10.5% Identity: 26% PDB header:transport protein Chain: A: PDB Molecule:periplasmic alpha-galactoside-binding protein; PDBTitle: structure of the periplasmic binding protein melb (atu4661) in complex2 with melibiose from agrobacterium fabrum c58 Phyre2 PDB 1e7l chain A domain 1 Region: 118 - 125 Aligned: 8 Modelled: 8 Confidence: 8.4% Identity: 50% Fold: LEM/SAP HeH motif Superfamily: Recombination endonuclease VII, C-terminal and dimerization domains Family: Recombination endonuclease VII, C-terminal and dimerization domains Phyre2 PDB 2wok chain A Region: 104 - 123 Aligned: 20 Modelled: 20 Confidence: 8.0% Identity: 35% PDB header:peptide binding protein/peptide Chain: A: PDB Molecule:clavulanic acid biosynthesis oligopeptide binding protein PDBTitle: clavulanic acid biosynthesis oligopeptide binding protein 2 complexed2 with bradykinin Phyre2 PDB 2knc chain A Region: 62 - 106 Aligned: 45 Modelled: 45 Confidence: 7.4% Identity: 9% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 1rgo chain A domain 2 Region: 116 - 121 Aligned: 6 Modelled: 6 Confidence: 7.0% Identity: 67% Fold: CCCH zinc finger Superfamily: CCCH zinc finger Family: CCCH zinc finger Phyre2 PDB 1hst chain A Region: 118 - 129 Aligned: 12 Modelled: 12 Confidence: 6.5% Identity: 33% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Linker histone H1/H5 Phyre2 PDB 2rqp chain A Region: 117 - 129 Aligned: 13 Modelled: 13 Confidence: 6.3% Identity: 23% PDB header:gene regulation Chain: A: PDB Molecule:heterochromatin protein 1-binding protein 3; PDBTitle: the solution structure of heterochromatin protein 1-binding2 protein 74 histone h1 like domain Phyre2 PDB 4faj chain A Region: 102 - 121 Aligned: 20 Modelled: 20 Confidence: 6.3% Identity: 15% PDB header:peptide binding protein Chain: A: PDB Molecule:prgz; PDBTitle: structure and mode of peptide binding of pheromone receptor prgz Phyre2 1 c5v7pA_ 2 c4a2nB_ 3 c4quvB_ 4 d1s7ia_ 5 c1p58F_ 6 c1p58E_ 7 c3j2pD_ 8 c5wsnD_ 9 c5ht7A_ 10 c4b03D_ 11 c4cbfB_ 12 c5ireD_ 13 c6epzA_ 14 d1e7la1 15 c2wokA_ 16 c2kncA_ 17 d1rgoa2 18 d1hsta_ 19 c2rqpA_ 20 c4fajA_ 21 22 23 24 25