1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	R	D	Y	T	A	P	R	W	A	H	A	W	A	G	E	P	R	P	A	R	W	H	P	A	N	Q	P	A	H	P	D	H	S	N	R	E	S	P	A	C	M	S	Q	S	T	T	P	Y	R	S	S	V	L	A	E	F	R	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	I	T	N	V	A	V	P	H	H	E	P	P	G	I	V	R	R	R	R	V	V	V	G	V	T	L	V	I	G	A	V	M	L	G	F	S	L	R	R	T	P	G	E	S	S	F	Y	W	L	T	L	A	L	A	A	V	W	I	A
Secondary structure
SS confidence
Disorder				?	?	?			?																															?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	A	L	M	S	G	P	L	H	L	G	G	I	C	W	R	G	R	N	Q	R	P	V	I	T	G	T	T	V	G	L	L	L	A	G	I	F	G	V	G	A	M	I	V	R	A	I	P	G	A	A	E	P	I	A	R	V	L	Q	F
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?	?	?																										?	?	?	?	?	?							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	H	Q	G	T	L	L	P	I	L	L	I	T	L	I	N	G	I	A	E	E	M	F	F	R	G	A	L	Y	T	A	L	G	R	R	Y	P	V	T	I	S	T	V	L	Y	V	G	A	T	M	A	S	A	N	L	M	L	G	F	A
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.
Sequence		A	I	F	V	G	T	V	C	A	L	E	R	R	A	S	G	G	V	L	A	P	I	L	T	H	F	V	W	G	L	I	M	V	F	A	L	P	P	L	F	A	V
Secondary structure
SS confidence
Disorder																																									?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 27%) Alpha helix ( 74%) Beta strand ( 0%) TM helix ( 50%) (View membrane topology prediction)

Rank Aligned region

PDB 4cad chain F Region: 74 - 274 Aligned: 196 Modelled: 201 Confidence: 99.7% Identity: 16% PDB header:protein binding Chain: F: PDB Molecule:ras and a-factor converting enzyme 1, rce1; PDBTitle: mechanism of farnesylated caax protein processing by the integral2 membrane protease rce1 Phyre2 PDB 4cad chain C Region: 82 - 274 Aligned: 190 Modelled: 193 Confidence: 99.7% Identity: 14% PDB header:protein binding Chain: C: PDB Molecule:ras and a-factor converting enzyme 1, rce1; PDBTitle: mechanism of farnesylated caax protein processing by the integral2 membrane protease rce1 Phyre2 PDB 2mx4 chain A Region: 1 - 8 Aligned: 8 Modelled: 8 Confidence: 30.3% Identity: 50% PDB header:translation,protein binding Chain: A: PDB Molecule:eukaryotic translation initiation factor 4e-binding protein PDBTitle: nmr structure of phosphorylated 4e-bp2 Phyre2 PDB 4a1s chain E Region: 14 - 19 Aligned: 6 Modelled: 6 Confidence: 22.5% Identity: 83% PDB header:cell cycle Chain: E: PDB Molecule:re60102p; PDBTitle: crystallographic structure of the pins:insc complex Phyre2 PDB 2m0q chain A Region: 201 - 256 Aligned: 54 Modelled: 56 Confidence: 22.1% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily e member 2; PDBTitle: solution nmr analysis of intact kcne2 in detergent micelles2 demonstrate a straight transmembrane helix Phyre2 PDB 2l1n chain A Region: 4 - 22 Aligned: 16 Modelled: 19 Confidence: 18.3% Identity: 38% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the protein yp_399305.1 Phyre2 PDB 2jpw chain A Region: 15 - 21 Aligned: 7 Modelled: 7 Confidence: 14.7% Identity: 86% PDB header:contractile protein Chain: A: PDB Molecule:troponin i, cardiac muscle; PDBTitle: solution structure of the bisphosphorylated cardiac2 specific n-extension of cardiac troponin i Phyre2 PDB 4luq chain B Region: 8 - 19 Aligned: 12 Modelled: 12 Confidence: 13.4% Identity: 50% PDB header:protein binding/toxin inhibitor Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of virulence effector tse3 in complex with2 neutralizer tsi3 Phyre2 PDB 2l35 chain A Region: 142 - 200 Aligned: 59 Modelled: 59 Confidence: 12.6% Identity: 14% PDB header:protein binding Chain: A: PDB Molecule:dap12-nkg2c_tm; PDBTitle: structure of the dap12-nkg2c transmembrane heterotrimer Phyre2 PDB 2vea chain A domain 2 Region: 14 - 35 Aligned: 22 Modelled: 22 Confidence: 11.3% Identity: 32% Fold: Profilin-like Superfamily: GAF domain-like Family: Phytochrome-specific domain Phyre2 PDB 3dh4 chain A Region: 68 - 158 Aligned: 84 Modelled: 91 Confidence: 10.8% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 4huq chain S Region: 212 - 280 Aligned: 69 Modelled: 69 Confidence: 10.6% Identity: 16% PDB header:hydrolase Chain: S: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a transporter Phyre2 PDB 6ht4 chain A Region: 57 - 73 Aligned: 17 Modelled: 17 Confidence: 9.5% Identity: 41% PDB header:unknown function Chain: A: PDB Molecule:ns5a; PDBTitle: nmr structure of ns5a-d2 (jfh1) peptide (304-323) Phyre2 PDB 2k21 chain A Region: 235 - 254 Aligned: 20 Modelled: 20 Confidence: 8.3% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily e PDBTitle: nmr structure of human kcne1 in lmpg micelles at ph 6.0 and2 40 degree c Phyre2 PDB 3tds chain C Region: 151 - 245 Aligned: 95 Modelled: 95 Confidence: 8.1% Identity: 16% PDB header:membrane protein Chain: C: PDB Molecule:formate/nitrite transporter; PDBTitle: crystal structure of hsc f194i Phyre2 PDB 1cmc chain A Region: 10 - 28 Aligned: 19 Modelled: 19 Confidence: 7.3% Identity: 26% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: Met repressor, MetJ (MetR) Phyre2 PDB 2xq2 chain A Region: 62 - 158 Aligned: 90 Modelled: 97 Confidence: 7.2% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 3c2w chain A domain 2 Region: 14 - 21 Aligned: 8 Modelled: 8 Confidence: 7.1% Identity: 38% Fold: Profilin-like Superfamily: GAF domain-like Family: Phytochrome-specific domain Phyre2 PDB 2e6x chain D Region: 7 - 12 Aligned: 6 Modelled: 6 Confidence: 6.8% Identity: 33% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein ttha1281; PDBTitle: x-ray structure of tt1592 from thermus thermophilus hb8 Phyre2 PDB 5zvt chain M Region: 33 - 55 Aligned: 23 Modelled: 23 Confidence: 6.7% Identity: 13% PDB header:virus Chain: M: PDB Molecule:n-terminus of outer capsid protein vp5; PDBTitle: structure of rna polymerase complex and genome within a dsrna virus2 provides insights into the mechanisms of transcription and assembly Phyre2 1 c4cadF_ 2 c4cadC_ 3 c2mx4A_ 4 c4a1sE_ 5 c2m0qA_ 6 c2l1nA_ 7 c2jpwA_ 8 c4luqB_ 9 c2l35A_ 10 d2veaa2 11 c3dh4A_ 12 c4huqS_ 13 c6ht4A_ 14 c2k21A_ 15 c3tdsC_ 16 d1cmca_ 17 c2xq2A_ 18 d3c2wa2 19 c2e6xD_ 20 c5zvtM_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99