1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	T	V	A	F	V	A	T	A	S	I	V	I	T	P	A	A	I	V	L	L	G	P	R	L	D	A	L	D	V	R	R	L	V	R	R	L	L	G	R	P	D	P	V	H	K	P	V	K	Q	L	F	W	Y	R	S	S	K	F
Secondary structure
SS confidence
Disorder		?																															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	M	R	R	W	L	P	V	G	T	A	V	V	A	L	L	V	L	L	G	L	P	F	L	S	V	K	W	G	F	P	D	D	R	V	L	P	R	S	A	S	A	R	Q	V	G	D	I	L	R	D	D	F	G	H	D	P	A	T	Q
Secondary structure
SS confidence
Disorder																																?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	P	I	V	V	P	D	A	R	G	L	G	P	V	E	L	D	S	Y	A	A	E	L	S	R	V	P	D	V	S	A	V	A	A	P	T	G	T	F	V	D	G	S	W	V	G	T	P	R	G	A	T	G	L	A	E	G	S	A	F
Secondary structure
SS confidence
Disorder												?																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	T	V	S	S	T	A	P	L	F	S	R	A	S	D	I	Q	L	K	R	L	H	Q	V	A	G	P	A	G	R	S	V	V	M	A	G	V	A	Q	V	N	R	D	S	V	D	A	V	T	D	R	L	P	M	V	L	G	L	I	A
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	I	T	Y	V	L	L	F	L	L	T	G	S	V	V	L	P	A	K	A	L	V	C	N	V	L	S	L	T	A	A	F	G	A	L	V	W	I	F	Q	E	G	H	F	G	A	L	G	T	T	P	S	G	T	L	V	A	N	M	P
Secondary structure
SS confidence
Disorder																																																		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	L	L	F	C	I	A	F	G	L	S	M	D	Y	E	V	F	L	V	S	R	I	R	E	Y	W	L	E	S	G	A	A	R	P	A	R	R	S	V	A	E	V	H	A	A	N	D	E	S	V	A	L	G	V	A	R	T	G	R	V
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		I	T	A	A	A	L	V	M	S	M	S	F	A	A	L	I	A	A	H	V	S	F	M	R	M	F	G	L	G	L	T	L	A	V	A	A	D	A	T	L	V	R	M	V	V	V	P	A	F	M	H	V	T	G	R	W	N	W	W	A
Secondary structure
SS confidence
Disorder																		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470
Sequence		P	R	P	L	A	W	L	H	E	R	F	G	V	S	E	A	A	E	P	V	S	R	R	R	S	H	A	G	G	L	G	K	I	A	G	R	S	D	G	Q	T	I	P	A	S	L	T	R	N	G
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 60%) Beta strand ( 5%) TM helix ( 34%) (View membrane topology prediction)

Rank Aligned region

PDB 6ajj chain A Region: 1 - 446 Aligned: 411 Modelled: 417 Confidence: 100.0% Identity: 31% PDB header:membrane protein, hydrolase Chain: A: PDB Molecule:drug exporters of the rnd superfamily-like protein, PDBTitle: crystal structure of mycolic acid transporter mmpl3 from mycobacterium2 smegmatis complexed with ica38 Phyre2 PDB 5khn chain B Region: 51 - 430 Aligned: 351 Modelled: 352 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:rnd transporter; PDBTitle: crystal structures of the burkholderia multivorans hopanoid2 transporter hpnn Phyre2 PDB 6dmo chain A Region: 2 - 423 Aligned: 365 Modelled: 374 Confidence: 100.0% Identity: 16% PDB header:protein binding Chain: A: PDB Molecule:protein patched homolog 1; PDBTitle: cryo-em structure of human ptch1 with three mutations2 l282q/t500f/p504l Phyre2 PDB 5lq3 chain F Region: 3 - 423 Aligned: 383 Modelled: 393 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: F: PDB Molecule:cmeb; PDBTitle: structures and transport dynamics of the campylobacter jejuni2 multidrug efflux pump cmeb Phyre2 PDB 3aqp chain B Region: 3 - 415 Aligned: 315 Modelled: 328 Confidence: 100.0% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:probable secdf protein-export membrane protein; PDBTitle: crystal structure of secdf, a translocon-associated membrane protein,2 from thermus thrmophilus Phyre2 PDB 6ows chain B Region: 1 - 416 Aligned: 378 Modelled: 388 Confidence: 100.0% Identity: 17% PDB header:membrane protein Chain: B: PDB Molecule:efflux pump membrane transporter; PDBTitle: cryo-em structure of an acinetobacter baumannii multidrug efflux pump Phyre2 PDB 3jd8 chain A Region: 47 - 416 Aligned: 342 Modelled: 342 Confidence: 100.0% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:niemann-pick c1 protein; PDBTitle: cryo-em structure of the full-length human npc1 at 4.4 angstrom Phyre2 PDB 3k07 chain A Region: 1 - 413 Aligned: 369 Modelled: 377 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:cation efflux system protein cusa; PDBTitle: crystal structure of cusa Phyre2 PDB 4mt1 chain A Region: 1 - 416 Aligned: 377 Modelled: 386 Confidence: 100.0% Identity: 20% PDB header:membrane protein, tranport protein Chain: A: PDB Molecule:drug efflux protein; PDBTitle: crystal structure of the neisseria gonorrhoeae mtrd inner membrane2 multidrug efflux pump Phyre2 PDB 5xam chain A Region: 1 - 416 Aligned: 326 Modelled: 345 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:protein translocase subunit secd; PDBTitle: crystal structure of secdf in i form at 4 a resolution Phyre2 PDB 2v50 chain A Region: 2 - 409 Aligned: 361 Modelled: 380 Confidence: 100.0% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein mexb; PDBTitle: the missing part of the bacterial mexab-oprm system: structural2 determination of the multidrug exporter mexb Phyre2 PDB 1oy8 chain A Region: 1 - 416 Aligned: 359 Modelled: 360 Confidence: 100.0% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:acriflavine resistance protein b; PDBTitle: structural basis of multiple drug binding capacity of the acrb2 multidrug efflux pump Phyre2 PDB 4k0e chain A Region: 3 - 416 Aligned: 347 Modelled: 352 Confidence: 100.0% Identity: 21% PDB header:transport protein Chain: A: PDB Molecule:heavy metal cation tricomponent efflux pump znea(czca- PDBTitle: x-ray crystal structure of a heavy metal efflux pump, crystal form ii Phyre2 PDB 6csx chain A Region: 57 - 419 Aligned: 332 Modelled: 347 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:multidrug efflux pump subunit acrb; PDBTitle: single particles cryo-em structure of acrb d407a associated with lipid2 bilayer at 3.0 angstrom Phyre2 PDB 4k0e chain C Region: 56 - 419 Aligned: 324 Modelled: 330 Confidence: 100.0% Identity: 21% PDB header:transport protein Chain: C: PDB Molecule:heavy metal cation tricomponent efflux pump znea(czca- PDBTitle: x-ray crystal structure of a heavy metal efflux pump, crystal form ii Phyre2 PDB 5mg3 chain F Region: 62 - 416 Aligned: 283 Modelled: 297 Confidence: 99.9% Identity: 17% PDB header:chaperone Chain: F: PDB Molecule:protein translocase subunit secf; PDBTitle: em fitted model of bacterial holo-translocon Phyre2 PDB 1iwg chain A domain 8 Region: 188 - 416 Aligned: 198 Modelled: 201 Confidence: 99.9% Identity: 16% Fold: Multidrug efflux transporter AcrB transmembrane domain Superfamily: Multidrug efflux transporter AcrB transmembrane domain Family: Multidrug efflux transporter AcrB transmembrane domain Phyre2 PDB 1iwg chain A domain 7 Region: 223 - 415 Aligned: 165 Modelled: 179 Confidence: 99.9% Identity: 18% Fold: Multidrug efflux transporter AcrB transmembrane domain Superfamily: Multidrug efflux transporter AcrB transmembrane domain Family: Multidrug efflux transporter AcrB transmembrane domain Phyre2 PDB 5mg3 chain D Region: 223 - 416 Aligned: 164 Modelled: 180 Confidence: 99.9% Identity: 13% PDB header:chaperone Chain: D: PDB Molecule:protein translocase subunit secd; PDBTitle: em fitted model of bacterial holo-translocon Phyre2 PDB 1t4z chain A Region: 416 - 424 Aligned: 8 Modelled: 9 Confidence: 48.5% Identity: 38% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: KaiB-like Phyre2 1 c6ajjA_ 2 c5khnB_ 3 c6dmoA_ 4 c5lq3F_ 5 c3aqpB_ 6 c6owsB_ 7 c3jd8A_ 8 c3k07A_ 9 c4mt1A_ 10 c5xamA_ 11 c2v50A_ 12 c1oy8A_ 13 c4k0eA_ 14 c6csxA_ 15 c4k0eC_ 16 c5mg3F_ 17 d1iwga8 18 d1iwga7 19 c5mg3D_ 20 d1t4za_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99