1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	A	V	L	D	L	V	E	I	F	W	D	A	A	P	Y	V	V	V	A	I	A	V	V	G	T	W	W	R	Y	R	Y	D	K	F	G	W	T	T	R	S	S	Q	L	Y	E	S	R	L	L	S	I	G	S	P	M	F	H	F	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?																													?	?						?	?						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	L	L	V	I	M	G	H	V	M	G	L	F	I	P	D	S	W	T	R	A	F	G	M	S	D	H	L	Y	H	L	Q	A	L	L	L	G	A	P	A	G	F	A	T	L	L	G	I	G	L	L	I	Y	R	R	R	I	Q	T	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	W	L	A	T	T	R	N	D	K	L	M	Y	L	V	L	V	C	A	I	V	A	G	L	A	C	T	L	M	G	A	T	H	E	G	D	M	H	D	Y	R	R	S	V	S	V	W	F	R	S	I	W	M	L	A	P	R	G	D	L
Secondary structure
SS confidence
Disorder		?	?	?																												?	?																										?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		M	A	Q	A	T	L	Y	Y	Q	V	H	V	L	I	A	L	A	L	F	A	L	W	P	F	T	R	L	V	H	A	F	S	A	P	I	A	Y	L	F	R	P	Y	I	V	Y	R	S	R	E	V	A	A	K	H	E	L	I	G	S	A
Secondary structure
SS confidence
Disorder		?																																																?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.
Sequence		P	R	R	R	G	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 76%) Beta strand ( 2%) TM helix ( 47%) (View membrane topology prediction)

Rank Aligned region

PDB 1y5i chain C domain 1 Region: 6 - 229 Aligned: 213 Modelled: 224 Confidence: 100.0% Identity: 29% Fold: Heme-binding four-helical bundle Superfamily: Respiratory nitrate reductase 1 gamma chain Family: Respiratory nitrate reductase 1 gamma chain Phyre2 PDB 5oc0 chain A Region: 56 - 233 Aligned: 155 Modelled: 177 Confidence: 77.0% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome b561; PDBTitle: structure of e. coli superoxide oxidase Phyre2 PDB 2knc chain A Region: 94 - 129 Aligned: 36 Modelled: 36 Confidence: 70.8% Identity: 17% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2klu chain A Region: 94 - 124 Aligned: 31 Modelled: 31 Confidence: 65.2% Identity: 23% PDB header:immune system, membrane protein Chain: A: PDB Molecule:t-cell surface glycoprotein cd4; PDBTitle: nmr structure of the transmembrane and cytoplasmic domains2 of human cd4 Phyre2 PDB 1kqf chain C Region: 56 - 203 Aligned: 124 Modelled: 124 Confidence: 57.6% Identity: 10% Fold: Heme-binding four-helical bundle Superfamily: Transmembrane di-heme cytochromes Family: Formate dehydrogenase N, cytochrome (gamma) subunit Phyre2 PDB 3kdp chain H Region: 89 - 115 Aligned: 27 Modelled: 27 Confidence: 49.9% Identity: 22% PDB header:hydrolase Chain: H: PDB Molecule:na+/k+ atpase gamma subunit transcript variant a; PDBTitle: crystal structure of the sodium-potassium pump Phyre2 PDB 3kdp chain G Region: 89 - 115 Aligned: 27 Modelled: 27 Confidence: 49.9% Identity: 22% PDB header:hydrolase Chain: G: PDB Molecule:na+/k+ atpase gamma subunit transcript variant a; PDBTitle: crystal structure of the sodium-potassium pump Phyre2 PDB 2k1a chain A Region: 94 - 122 Aligned: 29 Modelled: 29 Confidence: 46.2% Identity: 17% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: bicelle-embedded integrin alpha(iib) transmembrane segment Phyre2 PDB 5ir6 chain B Region: 16 - 168 Aligned: 153 Modelled: 153 Confidence: 45.0% Identity: 11% PDB header:oxidoreductase Chain: B: PDB Molecule:bd-type quinol oxidase subunit ii; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 2mkv chain A Region: 89 - 129 Aligned: 41 Modelled: 41 Confidence: 32.8% Identity: 22% PDB header:transport protein Chain: A: PDB Molecule:sodium/potassium-transporting atpase subunit gamma; PDBTitle: structure of the na,k-atpase regulatory protein fxyd2b in micelles Phyre2 PDB 2l8s chain A Region: 94 - 124 Aligned: 31 Modelled: 31 Confidence: 27.0% Identity: 23% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-1; PDBTitle: solution nmr structure of transmembrane and cytosolic regions of2 integrin alpha1 in detergent micelles Phyre2 PDB 2uui chain A Region: 95 - 167 Aligned: 73 Modelled: 73 Confidence: 22.7% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2jo1 chain A Region: 89 - 116 Aligned: 28 Modelled: 28 Confidence: 12.6% Identity: 29% PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles Phyre2 PDB 2jp3 chain A Region: 89 - 116 Aligned: 28 Modelled: 28 Confidence: 12.5% Identity: 18% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 PDB 2ww9 chain B Region: 191 - 218 Aligned: 25 Modelled: 28 Confidence: 12.1% Identity: 28% PDB header:ribosome Chain: B: PDB Molecule:protein transport protein sss1; PDBTitle: cryo-em structure of the active yeast ssh1 complex bound to the yeast2 80s ribosome Phyre2 PDB 2k1k chain A Region: 90 - 115 Aligned: 26 Modelled: 26 Confidence: 9.4% Identity: 38% PDB header:signaling protein Chain: A: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 4.3 Phyre2 PDB 2k1l chain B Region: 90 - 115 Aligned: 26 Modelled: 26 Confidence: 9.4% Identity: 38% PDB header:signaling protein Chain: B: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 Phyre2 PDB 2k1l chain A Region: 90 - 115 Aligned: 26 Modelled: 26 Confidence: 9.4% Identity: 38% PDB header:signaling protein Chain: A: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 Phyre2 PDB 2k1k chain B Region: 90 - 115 Aligned: 26 Modelled: 26 Confidence: 9.4% Identity: 38% PDB header:signaling protein Chain: B: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 4.3 Phyre2 PDB 4hqj chain G Region: 89 - 112 Aligned: 24 Modelled: 24 Confidence: 8.8% Identity: 21% PDB header:hydrolase/transport protein Chain: G: PDB Molecule:na+/k+ atpase gamma subunit transcript variant a; PDBTitle: crystal structure of na+,k+-atpase in the na+-bound state Phyre2 1 d1y5ic1 2 c5oc0A_ 3 c2kncA_ 4 c2kluA_ 5 d1kqfc_ 6 c3kdpH_ 7 c3kdpG_ 8 c2k1aA_ 9 c5ir6B_ 10 c2mkvA_ 11 c2l8sA_ 12 c2uuiA_ 13 c2jo1A_ 14 c2jp3A_ 15 c2ww9B_ 16 c2k1kA_ 17 c2k1lB_ 18 c2k1lA_ 19 c2k1kB_ 20 c4hqjG_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36