1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	G	W	F	A	H	T	L	R	P	A	M	L	A	A	G	R	S	D	R	L	G	R	I	V	E	R	S	P	L	T	R	G	V	V	R	R	F	V	P	G	D	T	L	D	D	V	V	D	I	V	T	A	L	R	D	S	G	R
Secondary structure
SS confidence
Disorder		?	?	?	?												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	L	S	I	D	Y	L	G	E	N	V	T	D	A	D	D	A	A	A	A	V	R	A	Y	L	G	L	L	D	V	L	G	R	R	G	D	I	A	C	D	G	V	R	P	L	E	V	S	L	K	L	S	A	L	G	Q	A	L	D	R
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?	?	?	?	?									?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	G	Q	K	I	A	L	D	N	A	R	A	I	C	E	R	A	E	R	V	G	A	W	V	T	V	D	A	E	D	H	T	T	T	D	S	T	L	S	I	S	G	D	L	R	V	D	F	P	W	L	G	T	V	V	Q	A	Y	L	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	T	L	A	D	C	A	E	L	A	A	V	G	A	R	V	R	L	C	K	G	A	Y	D	E	P	A	S	V	A	Y	R	D	A	A	Q	V	T	D	S	Y	L	R	C	L	R	V	L	T	A	G	R	G	Y	P	M	V	A	T	H
Secondary structure
SS confidence
Disorder																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	P	V	I	I	A	A	V	P	G	I	T	R	E	S	G	R	S	Q	G	D	F	E	Y	Q	M	L	Y	G	V	R	D	D	E	Q	R	R	L	T	G	A	G	N	H	V	R	V	Y	V	P	F	G	T	R	W	Y	G	Y	F	L
Secondary structure
SS confidence
Disorder																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.
Sequence		R	R	L	A	E	R	P	A	N	L	A	F	F	L	R	A	L	T	D	R	R	R	A	R	G	C	A	E	R
Secondary structure
SS confidence
Disorder																				?	?				?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 59%) Beta strand ( 11%)

Rank Aligned region

PDB 2ekg chain B Region: 5 - 306 Aligned: 289 Modelled: 302 Confidence: 100.0% Identity: 37% PDB header:oxidoreductase Chain: B: PDB Molecule:proline dehydrogenase/delta-1-pyrroline-5-carboxylate PDBTitle: structure of thermus thermophilus proline dehydrogenase inactivated by2 n-propargylglycine Phyre2 PDB 5ur2 chain C Region: 21 - 317 Aligned: 295 Modelled: 297 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: C: PDB Molecule:bifunctional protein puta; PDBTitle: crystal structure of proline utilization a (puta) from bdellovibrio2 bacteriovorus inactivated by n-propargylglycine Phyre2 PDB 4f9i chain A Region: 5 - 317 Aligned: 313 Modelled: 313 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:proline dehydrogenase/delta-1-pyrroline-5-carboxylate PDBTitle: crystal structure of proline utilization a (puta) from geobacter2 sulfurreducens pca Phyre2 PDB 4h6r chain A Region: 33 - 307 Aligned: 268 Modelled: 275 Confidence: 100.0% Identity: 39% PDB header:oxidoreductase Chain: A: PDB Molecule:proline dehydrogenase; PDBTitle: structure of reduced deinococcus radiodurans proline dehydrogenase Phyre2 PDB 1k87 chain A Region: 13 - 317 Aligned: 301 Modelled: 305 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:proline dehydrogenase; PDBTitle: crystal structure of e.coli puta (residues 1-669) Phyre2 PDB 3e2s chain A Region: 1 - 317 Aligned: 313 Modelled: 317 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:proline dehydrogenase; PDBTitle: crystal structure reduced puta86-630 mutant y540s complexed with l-2 proline Phyre2 PDB 1tj2 chain A Region: 17 - 317 Aligned: 297 Modelled: 301 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:bifunctional puta protein; PDBTitle: crystal structure of e. coli puta proline dehydrogenase domain2 (residues 86-669) complexed with acetate Phyre2 PDB 3haz chain A Region: 13 - 317 Aligned: 298 Modelled: 305 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:proline dehydrogenase; PDBTitle: crystal structure of bifunctional proline utilization a2 (puta) protein Phyre2 PDB 1tj1 chain A domain 2 Region: 42 - 317 Aligned: 274 Modelled: 276 Confidence: 100.0% Identity: 28% Fold: TIM beta/alpha-barrel Superfamily: FAD-linked oxidoreductase Family: Proline dehydrohenase domain of bifunctional PutA protein Phyre2 PDB 5kf6 chain B Region: 5 - 317 Aligned: 301 Modelled: 313 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: B: PDB Molecule:bifunctional protein puta; PDBTitle: structure of proline utilization a from sinorhizobium meliloti2 complexed with l-tetrahydrofuroic acid and nad+ in space group p21 Phyre2 PDB 5ux5 chain C Region: 20 - 320 Aligned: 289 Modelled: 301 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase/transferase Chain: C: PDB Molecule:bifunctional protein proline utilization a (puta); PDBTitle: structure of proline utilization a (puta) from corynebacterium2 freiburgense Phyre2 PDB 3itg chain A Region: 12 - 317 Aligned: 298 Modelled: 300 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:bifunctional protein puta; PDBTitle: structure the proline utilization a proline dehydrogenase2 domain (puta86-630) inactivated with n-propargylglycine Phyre2 PDB 5tnv chain A Region: 44 - 175 Aligned: 130 Modelled: 132 Confidence: 96.3% Identity: 17% PDB header:isomerase Chain: A: PDB Molecule:ap endonuclease, family protein 2; PDBTitle: crystal structure of a xylose isomerase-like tim barrel protein from2 mycobacterium smegmatis in complex with magnesium Phyre2 PDB 1tz9 chain A Region: 41 - 175 Aligned: 133 Modelled: 135 Confidence: 93.2% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: UxuA-like Phyre2 PDB 4k3z chain A Region: 44 - 175 Aligned: 124 Modelled: 132 Confidence: 92.3% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:d-erythrulose 4-phosphate dehydrogenase; PDBTitle: crystal structure of d-erythrulose 4-phosphate dehydrogenase from2 brucella melitensis, solved by iodide sad Phyre2 PDB 4ovx chain A Region: 42 - 175 Aligned: 124 Modelled: 134 Confidence: 91.3% Identity: 18% PDB header:isomerase Chain: A: PDB Molecule:xylose isomerase domain protein tim barrel; PDBTitle: crystal structure of xylose isomerase domain protein from planctomyces2 limnophilus dsm 3776 Phyre2 PDB 3dx5 chain A Region: 44 - 175 Aligned: 125 Modelled: 132 Confidence: 90.7% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:uncharacterized protein asbf; PDBTitle: crystal structure of the probable 3-dhs dehydratase asbf involved in2 the petrobactin synthesis from bacillus anthracis Phyre2 PDB 3cny chain A Region: 53 - 175 Aligned: 121 Modelled: 123 Confidence: 89.7% Identity: 12% PDB header:biosynthetic protein Chain: A: PDB Molecule:inositol catabolism protein iole; PDBTitle: crystal structure of a putative inositol catabolism protein iole2 (iole, lp_3607) from lactobacillus plantarum wcfs1 at 1.85 a3 resolution Phyre2 PDB 5hmq chain E Region: 48 - 175 Aligned: 118 Modelled: 118 Confidence: 87.6% Identity: 16% PDB header:lyase Chain: E: PDB Molecule:4-hydroxyphenylpyruvate dioxygenase; PDBTitle: xylose isomerase-like tim barrel/4-hydroxyphenylpyruvate dioxygenase2 fusion protein Phyre2 PDB 1qt1 chain A Region: 43 - 175 Aligned: 130 Modelled: 133 Confidence: 86.1% Identity: 13% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: Xylose isomerase Phyre2 1 c2ekgB_ 2 c5ur2C_ 3 c4f9iA_ 4 c4h6rA_ 5 c1k87A_ 6 c3e2sA_ 7 c1tj2A_ 8 c3hazA_ 9 d1tj1a2 10 c5kf6B_ 11 c5ux5C_ 12 c3itgA_ 13 c5tnvA_ 14 d1tz9a_ 15 c4k3zA_ 16 c4ovxA_ 17 c3dx5A_ 18 c3cnyA_ 19 c5hmqE_ 20 d1qt1a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99