1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	S	R	F	M	T	D	P	H	A	M	R	D	M	A	G	R	F	E	V	H	A	Q	T	V	E	D	E	A	R	R	M	W	A	S	A	Q	N	I	S	G	A	G	W	S	G	M	A	E	A	T	S	L	D	T	M	A	Q	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?								?										?											?	?			?		?	?					?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.
Sequence		N	Q	A	F	R	N	I	V	N	M	L	H	G	V	R	D	G	L	V	R	D	A	N	N	Y	E	Q	Q	E	Q	A	S	Q	Q	I	L	S	S
Secondary structure
SS confidence
Disorder																						?	?	?	?												?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 88%) Beta strand ( 0%)

Rank Aligned region

PDB 3ogi chain D Region: 7 - 97 Aligned: 74 Modelled: 74 Confidence: 100.0% Identity: 92% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:putative esat-6-like protein 7; PDBTitle: crystal structure of the mycobacterium tuberculosis h37rv esxop2 complex (rv2346c-rv2347c) Phyre2 PDB 1wa8 chain A domain 1 Region: 3 - 98 Aligned: 95 Modelled: 96 Confidence: 98.6% Identity: 20% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 3zbh chain C Region: 9 - 90 Aligned: 81 Modelled: 82 Confidence: 97.9% Identity: 20% PDB header:unknown function Chain: C: PDB Molecule:esxa; PDBTitle: geobacillus thermodenitrificans esxa crystal form i Phyre2 PDB 3gvm chain A Region: 3 - 90 Aligned: 87 Modelled: 88 Confidence: 97.7% Identity: 16% PDB header:viral protein Chain: A: PDB Molecule:putative uncharacterized protein sag1039; PDBTitle: structure of the homodimeric wxg-100 family protein from streptococcus2 agalactiae Phyre2 PDB 4lws chain A Region: 8 - 98 Aligned: 90 Modelled: 91 Confidence: 97.6% Identity: 22% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 4iog chain D Region: 1 - 87 Aligned: 85 Modelled: 87 Confidence: 97.6% Identity: 24% PDB header:unknown function Chain: D: PDB Molecule:secreted protein esxb; PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne Phyre2 PDB 2vs0 chain B Region: 8 - 87 Aligned: 79 Modelled: 80 Confidence: 97.5% Identity: 14% PDB header:cell invasion Chain: B: PDB Molecule:virulence factor esxa; PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa Phyre2 PDB 1wa8 chain B domain 1 Region: 8 - 90 Aligned: 82 Modelled: 83 Confidence: 96.6% Identity: 10% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 4lws chain B Region: 1 - 86 Aligned: 85 Modelled: 86 Confidence: 96.1% Identity: 14% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 2kg7 chain B Region: 3 - 90 Aligned: 87 Modelled: 88 Confidence: 95.4% Identity: 22% PDB header:unknown function Chain: B: PDB Molecule:esat-6-like protein esxh; PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288 Phyre2 PDB 3m0d chain C Region: 54 - 96 Aligned: 43 Modelled: 43 Confidence: 76.3% Identity: 19% PDB header:signaling protein Chain: C: PDB Molecule:tnf receptor-associated factor 1; PDBTitle: crystal structure of the traf1:traf2:ciap2 complex Phyre2 PDB 3m06 chain F Region: 54 - 96 Aligned: 43 Modelled: 43 Confidence: 66.6% Identity: 19% PDB header:protein binding Chain: F: PDB Molecule:tnf receptor-associated factor 2; PDBTitle: crystal structure of traf2 Phyre2 PDB 2dw3 chain A Region: 19 - 47 Aligned: 29 Modelled: 29 Confidence: 51.2% Identity: 38% PDB header:photosynthesis Chain: A: PDB Molecule:intrinsic membrane protein pufx; PDBTitle: solution structure of the rhodobacter sphaeroides pufx2 membrane protein Phyre2 PDB 3ag7 chain A Region: 11 - 95 Aligned: 82 Modelled: 85 Confidence: 28.3% Identity: 16% PDB header:plant protein Chain: A: PDB Molecule:putative uncharacterized protein f9e10.5; PDBTitle: an auxilin-like j-domain containing protein, jac1 j-domain Phyre2 PDB 1pqu chain A domain 2 Region: 38 - 50 Aligned: 13 Modelled: 13 Confidence: 26.9% Identity: 54% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: GAPDH-like Phyre2 PDB 1wte chain A Region: 54 - 79 Aligned: 26 Modelled: 26 Confidence: 25.6% Identity: 42% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Restriction endonuclease EcoO109IR Phyre2 PDB 1mb4 chain A domain 2 Region: 38 - 50 Aligned: 13 Modelled: 13 Confidence: 19.8% Identity: 54% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: GAPDH-like Phyre2 PDB 1t4b chain A domain 2 Region: 38 - 50 Aligned: 13 Modelled: 13 Confidence: 19.7% Identity: 46% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: GAPDH-like Phyre2 PDB 2la2 chain A Region: 64 - 93 Aligned: 30 Modelled: 30 Confidence: 19.5% Identity: 27% PDB header:antimicrobial protein Chain: A: PDB Molecule:cecropin; PDBTitle: solution structure of papiliocin isolated from the swallowtail2 butterfly, papilio xuthus Phyre2 PDB 2gz1 chain A domain 2 Region: 38 - 50 Aligned: 13 Modelled: 13 Confidence: 19.5% Identity: 46% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: GAPDH-like Phyre2 1 c3ogiD_ 2 d1wa8a1 3 c3zbhC_ 4 c3gvmA_ 5 c4lwsA_ 6 c4iogD_ 7 c2vs0B_ 8 d1wa8b1 9 c4lwsB_ 10 c2kg7B_ 11 c3m0dC_ 12 c3m06F_ 13 c2dw3A_ 14 c3ag7A_ 15 d1pqua2 16 d1wtea_ 17 d1mb4a2 18 d1t4ba2 19 c2la2A_ 20 d2gz1a2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66