1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	E	V	P	H	V	L	G	I	V	L	A	G	G	E	G	K	R	L	Y	P	L	T	A	D	R	A	K	P	A	V	P	F	G	G	A	Y	R	L	I	D	F	V	L	S	N	L	V	N	A	R	Y	L	R	I	C	V	L	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	Y	K	S	H	S	L	D	R	H	I	S	Q	N	W	R	L	S	G	L	A	G	E	Y	I	T	P	V	P	A	Q	Q	R	L	G	P	R	W	Y	T	G	S	A	D	A	I	Y	Q	S	L	N	L	I	Y	D	E	D	P	D	Y
Secondary structure
SS confidence
Disorder																	?	?	?	?	?		?									?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	V	V	F	G	A	D	H	V	Y	R	M	D	P	E	Q	M	V	R	F	H	I	D	S	G	A	G	A	T	V	A	G	I	R	V	P	R	E	N	A	T	A	F	G	C	I	D	A	D	D	S	G	R	I	R	S	F	V	E	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	L	E	P	P	G	T	P	D	D	P	D	T	T	F	V	S	M	G	N	Y	I	F	T	T	K	V	L	I	D	A	I	R	A	D	A	D	D	D	H	S	D	H	D	M	G	G	D	I	V	P	R	L	V	A	D	G	M	A	A
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?																													?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	Y	D	F	S	D	N	E	V	P	G	A	T	D	R	D	R	A	Y	W	R	D	V	G	T	L	D	A	F	Y	D	A	H	M	D	L	V	S	V	H	P	V	F	N	L	Y	N	K	R	W	P	I	R	G	E	S	E	N	L	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	A	K	F	V	N	G	G	S	A	Q	E	S	V	V	G	A	G	S	I	I	S	A	A	S	V	R	N	S	V	L	S	S	N	V	V	V	D	D	G	A	I	V	E	G	S	V	I	M	P	G	T	R	V	G	R	G	A	V	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.
Sequence		R	H	A	I	L	D	K	N	V	V	V	G	P	G	E	M	V	G	V	D	L	E	K	D	R	E	R	F	A	I	S	A	G	G	V	V	A	V	G	K	G	V	W	I
Secondary structure
SS confidence
Disorder																																								?	?	?	?		?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 20%) Beta strand ( 34%)

Rank Aligned region

PDB 5l6s chain F Region: 2 - 402 Aligned: 387 Modelled: 401 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: F: PDB Molecule:glucose-1-phosphate adenylyltransferase; PDBTitle: crystal structure of e. coli adp-glucose pyrophosphorylase (agpase) in2 complex with a positive allosteric regulator beta-fructose-1,6-3 diphosphate (fbp) - agpase*fbp Phyre2 PDB 3brk chain X Region: 4 - 401 Aligned: 381 Modelled: 392 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: X: PDB Molecule:glucose-1-phosphate adenylyltransferase; PDBTitle: crystal structure of adp-glucose pyrophosphorylase from agrobacterium2 tumefaciens Phyre2 PDB 1yp3 chain C Region: 5 - 404 Aligned: 382 Modelled: 385 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: C: PDB Molecule:glucose-1-phosphate adenylyltransferase small PDBTitle: crystal structure of potato tuber adp-glucose2 pyrophosphorylase in complex with atp Phyre2 PDB 6jlw chain J Region: 5 - 403 Aligned: 372 Modelled: 399 Confidence: 100.0% Identity: 15% PDB header:translation Chain: J: PDB Molecule:translation initiation factor eif-2b subunit epsilon; PDBTitle: eif2 - eif2b complex Phyre2 PDB 3d98 chain A Region: 4 - 392 Aligned: 360 Modelled: 389 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:bifunctional protein glmu; PDBTitle: crystal structure of glmu from mycobacterium tuberculosis, ligand-free2 form Phyre2 PDB 6i3m chain G Region: 5 - 403 Aligned: 376 Modelled: 399 Confidence: 100.0% Identity: 15% PDB header:translation Chain: G: PDB Molecule:translation initiation factor eif-2b subunit epsilon; PDBTitle: eif2b:eif2 complex, phosphorylated on eif2 alpha serine 52. Phyre2 PDB 2qkx chain A Region: 4 - 396 Aligned: 358 Modelled: 392 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:bifunctional protein glmu; PDBTitle: n-acetyl glucosamine 1-phosphate uridyltransferase from mycobacterium2 tuberculosis complex with n-acetyl glucosamine 1-phosphate Phyre2 PDB 5b04 chain I Region: 5 - 403 Aligned: 377 Modelled: 399 Confidence: 100.0% Identity: 14% PDB header:translation Chain: I: PDB Molecule:probable translation initiation factor eif-2b subunit PDBTitle: crystal structure of the eukaryotic translation initiation factor 2b2 from schizosaccharomyces pombe Phyre2 PDB 3d8v chain A Region: 1 - 404 Aligned: 374 Modelled: 395 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:bifunctional protein glmu; PDBTitle: crystal structure of glmu from mycobacterium tuberculosis2 in complex with uridine-diphosphate-n-acetylglucosamine Phyre2 PDB 5b04 chain F Region: 1 - 384 Aligned: 360 Modelled: 384 Confidence: 100.0% Identity: 18% PDB header:translation Chain: F: PDB Molecule:probable translation initiation factor eif-2b subunit PDBTitle: crystal structure of the eukaryotic translation initiation factor 2b2 from schizosaccharomyces pombe Phyre2 PDB 6qg2 chain F Region: 6 - 380 Aligned: 351 Modelled: 366 Confidence: 100.0% Identity: 15% PDB header:translation Chain: F: PDB Molecule:translation initiation factor eif-2b subunit gamma; PDBTitle: structure of eif2b-eif2 (phosphorylated at ser51) complex (model a) Phyre2 PDB 1hm8 chain A Region: 8 - 396 Aligned: 351 Modelled: 373 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:udp-n-acetylglucosamine-1-phosphate uridyltransferase; PDBTitle: crystal structure of s.pneumoniae n-acetylglucosamine-1-phosphate2 uridyltransferase, glmu, bound to acetyl coenzyme a Phyre2 PDB 2v0h chain A Region: 5 - 380 Aligned: 347 Modelled: 361 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:bifunctional protein glmu; PDBTitle: characterization of substrate binding and catalysis of the2 potential antibacterial target n-acetylglucosamine-1-3 phosphate uridyltransferase (glmu) Phyre2 PDB 1fwy chain A Region: 5 - 373 Aligned: 323 Modelled: 339 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:udp-n-acetylglucosamine pyrophosphorylase; PDBTitle: crystal structure of n-acetylglucosamine 1-phosphate2 uridyltransferase bound to udp-glcnac Phyre2 PDB 6ezo chain F Region: 6 - 383 Aligned: 340 Modelled: 351 Confidence: 100.0% Identity: 17% PDB header:membrane protein Chain: F: PDB Molecule:translation initiation factor eif-2b subunit gamma; PDBTitle: eukaryotic initiation factor eif2b in complex with isrib Phyre2 PDB 6ezo chain J Region: 16 - 403 Aligned: 366 Modelled: 388 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: J: PDB Molecule:human eukaryotic initiation factor eif2b epsilon subunits; PDBTitle: eukaryotic initiation factor eif2b in complex with isrib Phyre2 PDB 2oi6 chain A Region: 5 - 396 Aligned: 362 Modelled: 377 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:bifunctional protein glmu; PDBTitle: e. coli glmu- complex with udp-glcnac, coa and glcn-1-po4 Phyre2 PDB 3foq chain A Region: 4 - 402 Aligned: 344 Modelled: 365 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:bifunctional protein glmu; PDBTitle: crystal structure of n-acetylglucosamine-1-phosphate2 uridyltransferase (glmu) from mycobacterium tuberculosis in3 a cubic space group. Phyre2 PDB 5vmk chain B Region: 7 - 404 Aligned: 346 Modelled: 379 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:bifunctional protein glmu; PDBTitle: crystal structure of a bifunctional glmu udp-n-acetylglucosamine2 diphosphorylase/glucosamine-1- phosphate n-acetyltransferase from3 acinetobacter baumannii Phyre2 PDB 2ggq chain A Region: 7 - 398 Aligned: 341 Modelled: 358 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:401aa long hypothetical glucose-1-phosphate PDBTitle: complex of hypothetical glucose-1-phosphate thymidylyltransferase from2 sulfolobus tokodaii Phyre2 1 c5l6sF_ 2 c3brkX_ 3 c1yp3C_ 4 c6jlwJ_ 5 c3d98A_ 6 c6i3mG_ 7 c2qkxA_ 8 c5b04I_ 9 c3d8vA_ 10 c5b04F_ 11 c6qg2F_ 12 c1hm8A_ 13 c2v0hA_ 14 c1fwyA_ 15 c6ezoF_ 16 c6ezoJ_ 17 c2oi6A_ 18 c3foqA_ 19 c5vmkB_ 20 c2ggqA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210