1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	H	I	G	L	K	I	F	I	W	G	V	L	G	L	V	V	F	G	A	L	L	F	G	P	A	G	T	F	D	Y	W	Q	A	W	V	F	L	A	A	F	V	S	T	T	I	G	P	T	I	Y	L	A	R	N	D	P	A	A	L
Secondary structure
SS confidence
Disorder		?	?	?																																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	R	R	M	R	S	G	P	L	A	E	G	R	T	I	Q	K	F	I	V	I	G	A	F	L	G	F	F	A	M	M	V	L	S	A	C	D	H	R	Y	G	W	S	S	V	P	A	A	V	C	V	I	G	D	V	L	V	M	T	G
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?	?																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	G	I	A	M	L	V	V	I	Q	N	R	Y	A	A	S	T	V	R	V	E	A	G	Q	I	L	A	S	D	G	L	Y	K	I	V	R	H	P	M	Y	A	G	N	V	V	M	M	T	G	I	P	L	A	L	G	S	Y	W	A	M
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.
Sequence		F	I	L	V	P	G	T	L	V	L	V	F	R	I	L	D	E	E	K	L	L	T	Q	E	L	S	G	Y	R	E	Y	R	Q	L	V	R	Y	R	L	V	P	Y	V	W
Secondary structure
SS confidence
Disorder																																													?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 73%) Beta strand ( 2%) TM helix ( 51%) (View membrane topology prediction)

Rank Aligned region

PDB 4quv chain B Region: 2 - 224 Aligned: 215 Modelled: 223 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase, membrane protein Chain: B: PDB Molecule:delta(14)-sterol reductase; PDBTitle: structure of an integral membrane delta(14)-sterol reductase Phyre2 PDB 5v7p chain A Region: 3 - 223 Aligned: 208 Modelled: 221 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:protein-s-isoprenylcysteine o-methyltransferase; PDBTitle: atomic structure of the eukaryotic intramembrane ras methyltransferase2 icmt (isoprenylcysteine carboxyl methyltransferase), in complex with3 a monobody Phyre2 PDB 4a2n chain B Region: 36 - 221 Aligned: 180 Modelled: 186 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:isoprenylcysteine carboxyl methyltransferase; PDBTitle: crystal structure of ma-icmt Phyre2 PDB 4y9i chain A Region: 199 - 221 Aligned: 22 Modelled: 23 Confidence: 78.7% Identity: 36% PDB header:oxidoreductase Chain: A: PDB Molecule:mycobacterium tuberculosis paralogous family 11; PDBTitle: structure of f420-h2 dependent reductase (fdr-a) msmeg_2027 Phyre2 PDB 3r5y chain C Region: 199 - 221 Aligned: 22 Modelled: 23 Confidence: 72.7% Identity: 32% PDB header:unknown function Chain: C: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of a deazaflavin-dependent nitroreductase from nocardia2 farcinica, with co-factor f420 Phyre2 PDB 3r5w chain O Region: 199 - 221 Aligned: 22 Modelled: 23 Confidence: 70.3% Identity: 23% PDB header:oxidoreductase Chain: O: PDB Molecule:deazaflavin-dependent nitroreductase; PDBTitle: structure of ddn, the deazaflavin-dependent nitroreductase from2 mycobacterium tuberculosis involved in bioreductive activation of pa-3 824, with co-factor f420 Phyre2 PDB 3r5z chain B Region: 199 - 221 Aligned: 22 Modelled: 23 Confidence: 64.7% Identity: 23% PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of a deazaflavin-dependent reductase from nocardia2 farcinica, with co-factor f420 Phyre2 PDB 3h96 chain B Region: 199 - 221 Aligned: 23 Modelled: 23 Confidence: 61.9% Identity: 17% PDB header:flavoprotein Chain: B: PDB Molecule:f420-h2 dependent reductase a; PDBTitle: msmeg_3358 f420 reductase Phyre2 PDB 5e8j chain C Region: 198 - 214 Aligned: 17 Modelled: 17 Confidence: 48.8% Identity: 24% PDB header:translation Chain: C: PDB Molecule:rnmt-activating mini protein; PDBTitle: crystal structure of mrna cap guanine-n7 methyltransferase in complex2 with ram Phyre2 PDB 2knc chain A Region: 103 - 145 Aligned: 43 Modelled: 43 Confidence: 32.2% Identity: 12% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 1e7l chain A domain 1 Region: 157 - 164 Aligned: 8 Modelled: 8 Confidence: 26.6% Identity: 38% Fold: LEM/SAP HeH motif Superfamily: Recombination endonuclease VII, C-terminal and dimerization domains Family: Recombination endonuclease VII, C-terminal and dimerization domains Phyre2 PDB 2l8s chain A Region: 102 - 144 Aligned: 43 Modelled: 43 Confidence: 18.7% Identity: 12% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-1; PDBTitle: solution nmr structure of transmembrane and cytosolic regions of2 integrin alpha1 in detergent micelles Phyre2 PDB 5ht7 chain A Region: 139 - 160 Aligned: 22 Modelled: 22 Confidence: 16.6% Identity: 14% PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a transition-metal-ion-binding betagamma-2 crystallin from methanosaeta thermophila Phyre2 PDB 1nu9 chain C domain 1 Region: 190 - 213 Aligned: 24 Modelled: 24 Confidence: 15.2% Identity: 38% Fold: immunoglobulin/albumin-binding domain-like Superfamily: Staphylocoagulase Family: Staphylocoagulase Phyre2 PDB 6hlw chain B Region: 206 - 221 Aligned: 15 Modelled: 16 Confidence: 13.9% Identity: 20% PDB header:viral protein Chain: B: PDB Molecule:genome polyprotein; PDBTitle: crystal structure of human acbd3 gold domain in complex with 3a2 protein of enterovirus-a71 (fusion protein) Phyre2 PDB 1uc8 chain A domain 1 Region: 193 - 207 Aligned: 15 Modelled: 15 Confidence: 13.5% Identity: 27% Fold: PreATP-grasp domain Superfamily: PreATP-grasp domain Family: Lysine biosynthesis enzyme LysX, N-terminal domain Phyre2 PDB 5vhx chain E Region: 108 - 202 Aligned: 95 Modelled: 95 Confidence: 12.3% Identity: 12% PDB header:transport protein Chain: E: PDB Molecule:glutamate receptor 2,germ cell-specific gene 1-like PDBTitle: glua2-1xgsg1l bound to zk Phyre2 PDB 6hlt chain D Region: 206 - 221 Aligned: 15 Modelled: 16 Confidence: 12.0% Identity: 27% PDB header:viral protein Chain: D: PDB Molecule:genome polyprotein; PDBTitle: crystal structure of human acbd3 gold domain in complex with 3a2 protein of rhinovirus-14 (hrv14) Phyre2 PDB 1rgo chain A domain 2 Region: 155 - 160 Aligned: 6 Modelled: 6 Confidence: 11.3% Identity: 67% Fold: CCCH zinc finger Superfamily: CCCH zinc finger Family: CCCH zinc finger Phyre2 PDB 6hmv chain B Region: 206 - 221 Aligned: 15 Modelled: 16 Confidence: 10.5% Identity: 20% PDB header:viral protein Chain: B: PDB Molecule:genome polyprotein; PDBTitle: crystal structure of human acbd3 gold domain in complex with 3a2 protein of enterovirus-d68 (fusion protein, lvvy mutant) Phyre2 1 c4quvB_ 2 c5v7pA_ 3 c4a2nB_ 4 c4y9iA_ 5 c3r5yC_ 6 c3r5wO_ 7 c3r5zB_ 8 c3h96B_ 9 c5e8jC_ 10 c2kncA_ 11 d1e7la1 12 c2l8sA_ 13 c5ht7A_ 14 d1nu9c1 15 c6hlwB_ 16 d1uc8a1 17 c5vhxE_ 18 c6hltD_ 19 d1rgoa2 20 c6hmvB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44